Differentiating ulcerative colitis from other diseases: Difference between revisions
Jump to navigation
Jump to search
Usama Talib (talk | contribs) |
Usama Talib (talk | contribs) |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Ulcerative colitis should be differentiated from other causes of diarrhea. It is very important to differentiate it from [[Crohn's disease]] as the management of both conditions is different though the initial presentation may be confused for any of these disorders.<ref name="pmid28520586">{{cite journal| author=Fattahi MR, Malek-Hosseini SA, Sivandzadeh GR, Safarpour AR, Bagheri Lankarani K, Taghavi AR et al.| title=Clinical Course of Ulcerative Colitis After Liver Transplantation in Patients with Concomitant Primary Sclerosing Cholangitis and Ulcerative Colitis. | journal=Inflamm Bowel Dis | year= 2017 | volume= | issue= | pages= | pmid=28520586 | doi=10.1097/MIB.0000000000001105 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28520586 }} </ref><ref name="pmid28486626">{{cite journal| author=Burisch J, Ungaro R, Vind I, Prosberg MV, Bendtsen F, Colombel JF et al.| title=Proximal disease extension in patients with limited ulcerative colitis: a Danish population-based inception cohort. | journal=J Crohns Colitis | year= 2017 | volume= | issue= | pages= | pmid=28486626 | doi=10.1093/ecco-jcc/jjx066 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28486626 }} </ref> | |||
==Differentiating Ulcerative Colitis from other Diseases== | ==Differentiating Ulcerative Colitis from other Diseases== | ||
Revision as of 16:17, 19 May 2017
|
Ulcerative colitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Differentiating ulcerative colitis from other diseases On the Web |
|
American Roentgen Ray Society Images of Differentiating ulcerative colitis from other diseases |
|
FDA on Differentiating ulcerative colitis from other diseases |
|
CDC on Differentiating ulcerative colitis from other diseases |
|
Differentiating ulcerative colitis from other diseases in the news |
|
Blogs on Differentiating ulcerative colitis from other diseases |
|
Risk calculators and risk factors for Differentiating ulcerative colitis from other diseases |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Ulcerative colitis should be differentiated from other causes of diarrhea. It is very important to differentiate it from Crohn's disease as the management of both conditions is different though the initial presentation may be confused for any of these disorders.[1][2]
Differentiating Ulcerative Colitis from other Diseases
The following conditions may present in a similar manner as ulcerative colitis, and should be excluded:
- Crohn's disease
- Infectious colitis, which is typically detected on stool cultures
- Pseudomembranous colitis, or Clostridium difficile-associated colitis, bacterial upsets often seen following administration of antibiotics
- Ischemic colitis, inadequate blood supply to the intestine, which typically affects the elderly
- Radiation colitis in patients with previous pelvic radiotherapy
- Chemical colitis resulting from introduction of harsh chemicals into the colon from an enema or other procedure.
Differentiating Crohn's disease and Ulcerative Colitis
The most common disease that mimics the symptoms of Crohn's disease is ulcerative colitis, as both are inflammatory bowel diseases that can affect the colon with similar symptoms. It is important to differentiate these diseases, since the course of the diseases and treatments may be different. In some cases, however, it may not be possible to tell the difference, in which case the disease is classified as indeterminate colitis.[1][2][3][4][5][6]
| Crohn's disease | Ulcerative colitis | |
|---|---|---|
| Terminal ileum involvement | Commonly | Seldom |
| Colon involvement | Usually | Always |
| Rectum involvement | Seldom | Usually[7] |
| Involvement around the anus | Common[8] | Seldom |
| Bile duct involvement | No increase in rate of primary sclerosing cholangitis | Higher rate[9] |
| Distribution of Disease | Patchy areas of inflammation (Skip lesions) | Continuous area of inflammation[7] |
| Endoscopy | Deep geographic and serpiginous (snake-like) ulcers | Continuous ulcer |
| Depth of inflammation | May be transmural, deep into tissues[8] | Shallow, mucosal |
| Fistulae | Common[8] | Seldom |
| Stenosis | Common | Seldom |
| Autoimmune disease | Widely regarded as an autoimmune disease | No consensus |
| Cytokine response | Associated with Th1 | Vaguely associated with Th2 |
| Granulomas on biopsy | Can have granulomas[8] | Granulomas uncommon[7] |
| Surgical cure | Often returns following removal of affected part | Usually cured by removal of colon |
| Smoking | Higher risk for smokers | Lower risk for smokers[7] |
| Risk of Cancer | Lower than UC | Higher |
References
- ↑ 1.0 1.1 Fattahi MR, Malek-Hosseini SA, Sivandzadeh GR, Safarpour AR, Bagheri Lankarani K, Taghavi AR; et al. (2017). "Clinical Course of Ulcerative Colitis After Liver Transplantation in Patients with Concomitant Primary Sclerosing Cholangitis and Ulcerative Colitis". Inflamm Bowel Dis. doi:10.1097/MIB.0000000000001105. PMID 28520586.
- ↑ 2.0 2.1 Burisch J, Ungaro R, Vind I, Prosberg MV, Bendtsen F, Colombel JF; et al. (2017). "Proximal disease extension in patients with limited ulcerative colitis: a Danish population-based inception cohort". J Crohns Colitis. doi:10.1093/ecco-jcc/jjx066. PMID 28486626.
- ↑ Srivastava S, Kedia S, Kumar S, Pratap Mouli V, Dhingra R, Sachdev V; et al. (2015). "Serum human trefoil factor 3 is a biomarker for mucosal healing in ulcerative colitis patients with minimal disease activity". J Crohns Colitis. 9 (7): 575–9. doi:10.1093/ecco-jcc/jjv075. PMID 25964429.
- ↑ Karolewska-Bochenek K, Dziekiewicz M, Banaszkiewicz A (2017). "Budesonide MMX in pediatric patients with ulcerative colitis". J Crohns Colitis. doi:10.1093/ecco-jcc/jjx069. PMID 28505293.
- ↑ Silva M, Cardoso H, Macedo G (2017). "Patency Capsule Safety in Crohn's Disease". J Crohns Colitis. doi:10.1093/ecco-jcc/jjx064. PMID 28486597.
- ↑ Stidham RW, Cross RK (2016). "Endoscopy and cross-sectional imaging for assessing Crohn׳s disease activity". Tech Gastrointest Endosc. 18 (3): 123–130. doi:10.1016/j.tgie.2016.08.001. PMC 5405438. PMID 28458507.
- ↑ 7.0 7.1 7.2 7.3 Kornbluth, Asher (2004). "Ulcerative Colitis Practice Guidelines in Adults" (PDF). American Journal of Gastroenterology. 99 (7): 1371–1385. doi:10.1111/j.1572-0241.2004.40036.x. PMID 15233681. Retrieved 2006-11-08. Unknown parameter
|month=ignored (help); Unknown parameter|coauthors=ignored (help) - ↑ 8.0 8.1 8.2 8.3 Hanauer, Stephen B. (March 1 2001). "Management of Crohn's Disease in Adults" (PDF). American Journal of Gastroenterology. 96 (3): 635–643. doi:10.1111/j.1572-0241.2001.03671.x. PMID 11280528. Retrieved 2006-11-08. Unknown parameter
|coauthors=ignored (help); Check date values in:|date=(help) - ↑ Broomé, Ulrika (2006). "Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer". Seminars in Liver Disease. 26 (1): 31–41. doi:10.1055/s-2006-933561. PMID 16496231. Unknown parameter
|coauthors=ignored (help); Unknown parameter|month=ignored (help)