Diverticulitis pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
*Pathogenesis of diverticulitis includes three main processes which are change of the intestinal motility, increase of the lumenal pressure, and colonic microenviroment disorder which leads to infection after that.<ref name="pmid24430321">{{cite journal| author=Morris AM, Regenbogen SE, Hardiman KM, Hendren S| title=Sigmoid diverticulitis: a systematic review. | journal=JAMA | year= 2014 | volume= 311 | issue= 3 | pages= 287-97 | pmid=24430321 | doi=10.1001/jama.2013.282025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24430321 }} </ref> | *Pathogenesis of diverticulitis includes three main processes which are change of the intestinal motility, increase of the lumenal pressure, and colonic microenviroment disorder which leads to infection after that.<ref name="pmid24430321">{{cite journal| author=Morris AM, Regenbogen SE, Hardiman KM, Hendren S| title=Sigmoid diverticulitis: a systematic review. | journal=JAMA | year= 2014 | volume= 311 | issue= 3 | pages= 287-97 | pmid=24430321 | doi=10.1001/jama.2013.282025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24430321 }} </ref> | ||
*In a vivo test of diverticulitis patient colonic tissue with chemicals added, it was overt that there is neuro-alteration to the tissue. It showed increase contractility and loss of relaxation.<ref name="pmid16423891">{{cite journal| author=Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S et al.| title=Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. | journal=Gut | year= 2006 | volume= 55 | issue= 7 | pages= 946-53 | pmid=16423891 | doi=10.1136/gut.2005.076372 | pmc=1856307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16423891 }} </ref> | *In a vivo test of diverticulitis patient colonic tissue with chemicals added, it was overt that there is neuro-alteration to the tissue. It showed increase contractility and loss of relaxation.<ref name="pmid16423891">{{cite journal| author=Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S et al.| title=Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. | journal=Gut | year= 2006 | volume= 55 | issue= 7 | pages= 946-53 | pmid=16423891 | doi=10.1136/gut.2005.076372 | pmc=1856307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16423891 }} </ref> | ||
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===Gross pathology=== | ===Gross pathology=== | ||
Revision as of 18:40, 13 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Pathophysiology
Pathogenesis
- Pathogenesis of diverticulitis includes three main processes which are change of the intestinal motility, increase of the lumenal pressure, and colonic microenviroment disorder which leads to infection after that.[1]
- In a vivo test of diverticulitis patient colonic tissue with chemicals added, it was overt that there is neuro-alteration to the tissue. It showed increase contractility and loss of relaxation.[2]
Gross pathology
Histopathological Findings: Actinomycosis diverticulitis & abscess
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References
- ↑ Morris AM, Regenbogen SE, Hardiman KM, Hendren S (2014). "Sigmoid diverticulitis: a systematic review". JAMA. 311 (3): 287–97. doi:10.1001/jama.2013.282025. PMID 24430321.
- ↑ Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S; et al. (2006). "Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P." Gut. 55 (7): 946–53. doi:10.1136/gut.2005.076372. PMC 1856307. PMID 16423891.