Hirschsprung's disease causes: Difference between revisions
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==Causes== | ==Causes== | ||
*Normally, myentric and submucosal nerve plexuses regulate motility by allowing relaxation. In the absence of their migration, there’s over contracting which prevents passage of stool. | |||
*Absence of myentric and submucosal plexuses causes overcontraction of the smooth muscles of the rectum causing functional obstruction and chronic constipation. | |||
*Absence of these cells in the distal colon is believed to be due to genetic mutation causing failure of migration of these cells craniocaudally. | |||
*Defective differentiation of neuroblasts into neural crest cells is another suggested hypothesis explaining the disease. | |||
==References== | ==References== | ||
Revision as of 20:31, 13 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]
Overview
Causes
- Normally, myentric and submucosal nerve plexuses regulate motility by allowing relaxation. In the absence of their migration, there’s over contracting which prevents passage of stool.
- Absence of myentric and submucosal plexuses causes overcontraction of the smooth muscles of the rectum causing functional obstruction and chronic constipation.
- Absence of these cells in the distal colon is believed to be due to genetic mutation causing failure of migration of these cells craniocaudally.
- Defective differentiation of neuroblasts into neural crest cells is another suggested hypothesis explaining the disease.