Hirschsprung's disease medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Medications only play a supportive role in the management of Hirschsprung's disease. They are indicated to prevent complications of Hirschsprung disease, to prevent infections during reconstructive surgery, and to manage postoperative bowel function. Intravenous fluid resuscitation and maintenance, nasogastric decompression, and administration of intravenous antibiotics (as indicated) remain the cornerstones of initial medical management. | |||
==Medical Therapy== | ==Medical Therapy== | ||
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*Metronidazole is usually given. In older children, oral antibiotics can be given when they begin to improve and when they are no longer NPO. | *Metronidazole is usually given. In older children, oral antibiotics can be given when they begin to improve and when they are no longer NPO. | ||
===Empiric antimicrobial therapy=== | ===Empiric antimicrobial therapy=== | ||
* Preferred regimen (1)-Ampicillin (Marcillin, Omnipen, Principen) IV/IM: 1-2 g q4-6hr or 50-250 mg/kg/day divided q4-6hr; not to exceed 12 g/day | *:: Preferred regimen (1)-Ampicillin (Marcillin, Omnipen, Principen) IV/IM: 1-2 g q4-6hr or 50-250 mg/kg/day divided q4-6hr; not to exceed 12 g/day | ||
* Preferred regimen (2)-Gentamicin (Garamycin, Jenamicin) 3-5 mg/kg/day IV/IM divided q8hr | *:: Preferred regimen (2)-Gentamicin (Garamycin, Jenamicin) 3-5 mg/kg/day IV/IM divided q8hr | ||
* Preferred regimen (3)-Metronidazole children: 30 mg/kg/day orally/intravenously given in divided doses every 6 hours, maximum 4000 mg/day | *:: Preferred regimen (3)-Metronidazole children: 30 mg/kg/day orally/intravenously given in divided doses every 6 hours, maximum 4000 mg/day | ||
==References== | ==References== | ||
Revision as of 15:16, 16 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medications only play a supportive role in the management of Hirschsprung's disease. They are indicated to prevent complications of Hirschsprung disease, to prevent infections during reconstructive surgery, and to manage postoperative bowel function. Intravenous fluid resuscitation and maintenance, nasogastric decompression, and administration of intravenous antibiotics (as indicated) remain the cornerstones of initial medical management.
Medical Therapy
Supportive therapy
- All patients should be kept nothing by mouth (NPO)
- Patients should receive intravenous fluids
- A large tube (20-24 F) is introduced through the rectum, and small amounts of saline solution (10 to 20 mL) are instilled through the lumen of the tube in order to clear the lumen of the tube.
- The liquid rectal and colonic content is expected to drain through the lumen of the tube. The tube is then rotated in different directions and moved back and forth.
- The operator continues to instill small amounts of saline solution, allowing the evacuation of gas and liquid stool through the tube.
- Metronidazole is usually given. In older children, oral antibiotics can be given when they begin to improve and when they are no longer NPO.
Empiric antimicrobial therapy
- Preferred regimen (1)-Ampicillin (Marcillin, Omnipen, Principen) IV/IM: 1-2 g q4-6hr or 50-250 mg/kg/day divided q4-6hr; not to exceed 12 g/day
- Preferred regimen (2)-Gentamicin (Garamycin, Jenamicin) 3-5 mg/kg/day IV/IM divided q8hr
- Preferred regimen (3)-Metronidazole children: 30 mg/kg/day orally/intravenously given in divided doses every 6 hours, maximum 4000 mg/day