African trypanosomiasis history and symptoms: Difference between revisions
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The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the parasite (T. b. rhodesiense or T. b. gambiense) is causing the infection. | The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the parasite (T. b. rhodesiense or T. b. gambiense) is causing the infection. | ||
T. b. rhodesiense infection (East African sleeping sickness) | {| class="wikitable" | ||
! | |||
!Progression | |||
!Symptoms | |||
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|T. b. rhodesiense infection (East African sleeping sickness) | |||
|Rapid | |||
| | |||
* A large sore (a chancre) will develop at the site of the tsetse bite | |||
* Fever, headache, muscle and joint aches, and enlarged lymph node | |||
|- | |||
|T. b. gambiense infection (West African sleeping sickness) | |||
|slow | |||
| | |||
|} | |||
m | |||
In some patients,. Most patients develops within 1-2 weeks of the infective bite. Some people develop a rash. After a few weeks of infection, the parasite invades the central nervous system and eventually causes mental deterioration and other neurologic problems. Death ensues usually within months. | |||
T. b. gambiense infection (West African sleeping sickness) progresses more slowly. At first, there may be only mild symptoms. Infected persons may have intermittent fevers, headaches, muscle and joint aches, and malaise. Itching of the skin, swollen lymph nodes, and weight loss can occur. Usually, after 1-2 years, there is evidence of central nervous system involvement, with personality changes, daytime sleepiness with nighttime sleep disturbance, and progressive confusion. Other neurologic signs, such as partial paralysis or problems with balance or walking may occur, as well as hormonal imbalances. The course of untreated infection rarely lasts longer than 6-7 years and more often kills in about 3 years. | T. b. gambiense infection (West African sleeping sickness) progresses more slowly. At first, there may be only mild symptoms. Infected persons may have intermittent fevers, headaches, muscle and joint aches, and malaise. Itching of the skin, swollen lymph nodes, and weight loss can occur. Usually, after 1-2 years, there is evidence of central nervous system involvement, with personality changes, daytime sleepiness with nighttime sleep disturbance, and progressive confusion. Other neurologic signs, such as partial paralysis or problems with balance or walking may occur, as well as hormonal imbalances. The course of untreated infection rarely lasts longer than 6-7 years and more often kills in about 3 years. | ||
Revision as of 17:42, 22 June 2017
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African trypanosomiasis Microchapters |
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African trypanosomiasis history and symptoms On the Web |
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Risk calculators and risk factors for African trypanosomiasis history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Pilar Almonacid
Overview
History
Symptoms
Symptoms of African trypanosomiasis include:
| Symptoms | |
|---|---|
| Systemic |
|
| First stage (hemo-lyphatic stage) |
|
| Second stage (neurological or meningo-encephalic stage) |
|
The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the parasite (T. b. rhodesiense or T. b. gambiense) is causing the infection.
| Progression | Symptoms | |
|---|---|---|
| T. b. rhodesiense infection (East African sleeping sickness) | Rapid |
|
| T. b. gambiense infection (West African sleeping sickness) | slow |
m
In some patients,. Most patients develops within 1-2 weeks of the infective bite. Some people develop a rash. After a few weeks of infection, the parasite invades the central nervous system and eventually causes mental deterioration and other neurologic problems. Death ensues usually within months.
T. b. gambiense infection (West African sleeping sickness) progresses more slowly. At first, there may be only mild symptoms. Infected persons may have intermittent fevers, headaches, muscle and joint aches, and malaise. Itching of the skin, swollen lymph nodes, and weight loss can occur. Usually, after 1-2 years, there is evidence of central nervous system involvement, with personality changes, daytime sleepiness with nighttime sleep disturbance, and progressive confusion. Other neurologic signs, such as partial paralysis or problems with balance or walking may occur, as well as hormonal imbalances. The course of untreated infection rarely lasts longer than 6-7 years and more often kills in about 3 years.