Sandbox:Filariasis pathogenesis: Difference between revisions

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* The difference between the different nematodes causing lymphatic filariasis is in the shape and size of the worm.
* The difference between the nematodes causing lymphatic filariasis is in the shape and size of the worm.
* The Brugia worms are similar to the W. bancrofti but smaller.  
* The Brugia worms are similar to the W. bancrofti but smaller.  
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Revision as of 14:50, 27 June 2017

Type of filariasis Causative nematode Vectors Life cycle Illustrative image Comments
Lymphatic filariasis Wuchereria bancrofti 
  • Culex as C. pipiens
  • Aedes as A. aegypti
  • Anopheles as A. arabinensis
  • Coquillettidia.as C. juxtamansonia
  • Infected mosquito bite introduces the third stage larva onto the skin and then enters to the blood through the wound.
  • The larvae reside in the lymphatic vessels and mature to adult worms.
  • Adult worm produce sheathed microfiliae that migrate to lymph and blood. They have nocturnal periodicity.
  • Another mosquito ingests the microfiliae.
  • The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the midgut to reach the thoracic muscles
  • Microfiliae grow up inside the mosquito till third stage larvae.
  • In another bite to a host skin the mosquito introduces the larvae onto the skin.
  • The difference between the nematodes causing lymphatic filariasis is in the shape and size of the worm.
  • The Brugia worms are similar to the W. bancrofti but smaller.
Brugia timori and Brugia malayi
  • Mansonia
  • Aedes
Subcutaneous filariasis Loa loa filaria
  • Chrysops
  • C. silacea
  • C. dimidiata
Mansonella streptocerca
Onchocerca volvulus
Serous cavity filariasis Mansonella ozzardi
Mansonella perstans

Life cycles of the roundworms causing filariasis: