Sandbox:Filariasis pathogenesis: Difference between revisions

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{| class="wikitable"
 
!Type of filariasis
!Causative nematode
!Vectors
!Life cycle
!Illustrative image
!Comments
|-
| rowspan="2" |Lymphatic filariasis
|[[Wuchereria bancrofti]] 
|
* Culex as C. pipiens
* Aedes as A. aegypti
*  [[Anopheles]] as A. arabinensis
* Coquillettidia.as C. juxtamansonia
| rowspan="2" |
* Infected mosquito bite introduces the third stage larva onto the skin and then enters to the blood through the wound.
* The larvae develop to adult which reside in the '''lymphatic vessels'''.
* Adult worm produce sheathed microfiliae that migrate to lymph and blood. They have '''nocturnal periodicity'''.
* Another mosquito ingests the microfiliae.
* The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the [[midgut]] to reach the thoracic muscles
* Microfiliae grow up inside the mosquito till third stage larvae.
* In another bite to a host skin the mosquito introduces the larvae onto the skin.
| rowspan="2" |[[Image:W bancrofti LifeCycle.gif|350 px|center]]
| rowspan="2" |
* The difference between the nematodes causing lymphatic filariasis is in the shape and size of the worm.
* The Brugia worms are similar to the W. bancrofti but smaller.
|-
|[[Brugia timori]] and [[Brugia malayi]]
|
* Mansonia
* Aedes
|-
| rowspan="4" |Subcutaneous filariasis
|[[Loa loa filaria]]
|
* Chrysops
* C. silacea
* C. dimidiata
| rowspan="4" |
* Infected fly bite introduces the third stage larva onto the skin and then enters to the blood through the wound.
* The larvae develop to adult which reside in the '''subcutaneous tissue'''.
* Loa Loa adult worm produce sheathed microfilariae that are found in the blood during day and in the lungs during the non circulating phase. They have '''diurnal periodicity'''.
* Another fly ingests the microfiliae.
* After ingestion, the microfilariae lose their sheaths and migrate from the fly's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]].
* Microfiliae grow up inside the fly till third stage larvae.
* The third-stage infective larvae migrate to the fly's proboscis and in another bite the cycle restarts.
| rowspan="4" |[[Image:L loa LifeCycle.gif|350 px|center]]
| rowspan="4" |
* Unlike Loa Loa filaria, Mansonella streptocerca , Mansonella ozzardi and Onchocerca volvolus produce '''unsheathed non-periodic microfilariae'''.
* Mansonela streptocerca adults residue in the dermis.
* Onchocerca volvulus adults residue mainly in the subcutaneous nodules. Their microfilariae can be found in the peripheral [[blood]], [[urine]], and [[sputum]] but are typically found in the [[skin]] and in the [[Lymphatic|lymphatics]] of connective tissue.
|-
|[[Mansonella streptocerca]]
|
* Midge (genus Culicoides)
|-
|[[Mansonella ozzardi]]
|
* Midge (genus Culicoides)
|-
|[[Onchocerca volvulus]]
|
* Blackfly (genus Simulium)
|-
|Serous cavity filariasis
|[[Mansonella perstans]]
|
* Midge (genus Culicoides)
* Blackfly (genus Simulium)
|
* Infected midge bite introduces the third stage larva onto the skin and then enters to the blood through the wound.
* The larvae develop to adult which reside in the different body cavities like [[peritoneal cavity]], [[pleural cavity]], and less frequently in the [[pericardium]].
* Adult worm produce unsheathed subperiodic microfilariae that reaches the blood stream.
* Another midge ingests microfilariae during a [[blood]] meal.
* After [[ingestion]], the microfilariae migrate from the midge's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]].
* Microfiliae grow up inside the midge till third stage larvae.
* The third-stage infective larvae migrate to the midge's proboscis and in another bite the cycle restarts.
|[[Image:M perstans LifeCycle.gif|350 px|center]]
|
|}
Life cycles of the roundworms causing filariasis:

Revision as of 18:03, 27 June 2017