Pheochromocytoma history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Symptoms of pheochromocytoma include '''episodes''' of [[tachycardia]], [[sweating]] and [[headaches]].<ref name="pmid1988766">{{cite journal| author=Stein PP, Black HR| title=A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience. | journal=Medicine (Baltimore) | year= 1991 | volume= 70 | issue= 1 | pages= 46-66 | pmid=1988766 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1988766 }}</ref> | Symptoms of pheochromocytoma include '''episodes''' of [[tachycardia]], [[sweating]] and [[headaches]].<ref name="pmid1988766">{{cite journal| author=Stein PP, Black HR| title=A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience. | journal=Medicine (Baltimore) | year= 1991 | volume= 70 | issue= 1 | pages= 46-66 | pmid=1988766 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1988766 }}</ref> Most patients don't have all symptoms.Less common symptoms include cardiomyopathy and episodic hypotension.<ref name="pmid15132724">{{cite journal| author=Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N et al.| title=Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients. | journal=Eur J Endocrinol | year= 2004 | volume= 150 | issue= 5 | pages= 681-6 | pmid=15132724 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15132724 }}</ref> | ||
==History and Symptoms== | ==History and Symptoms== | ||
The | '''The hallmark symptoms''' of a pheochromocytoma are those of [[sympathetic nervous system]] hyperactivity, symptoms usually subside in less than one hour and they may include: | ||
*[[Palpitations]] | *[[Palpitations]] especially in epinephrine producing tumors.<ref name="pmid8325290">{{cite journal| author=Bravo EL, Gifford RW| title=Pheochromocytoma. | journal=Endocrinol Metab Clin North Am | year= 1993 | volume= 22 | issue= 2 | pages= 329-41 | pmid=8325290 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8325290 }}</ref> | ||
*[[Anxiety]] often resembling that of a [[panic attack]] | *[[Anxiety]] often resembling that of a [[panic attack]] | ||
*[[ | *[[Sweating]] | ||
*[[Headaches]] | *[[Headaches]]: occurs in 90 % of patients. | ||
* | *paroxysmal attacks of hypertension but some patients have normal blood pressure. | ||
* | *May be asymptomatic and discovered by incidence screening especially MEN patients. | ||
''Please note that not all patients with pheochromocytoma experience | ''Please note that not all patients with pheochromocytoma experience all classical symptoms''.<ref name="pmid151327242">{{cite journal| author=Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N et al.| title=Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients. | journal=Eur J Endocrinol | year= 2004 | volume= 150 | issue= 5 | pages= 681-6 | pmid=15132724 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15132724 }}</ref> | ||
'''Less common symptoms''' include: | |||
Cardiomyopathy: rare symptom due to catecholamine excess mimics takotsubo cardiomyopathy.<ref name="pmid19158054">{{cite journal| author=Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM| title=Catecholamine-induced cardiomyopathy. | journal=Endocr Pract | year= 2008 | volume= 14 | issue= 9 | pages= 1137-49 | pmid=19158054 | doi=10.4158/EP.14.9.1137 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19158054 }}</ref> Patient improves after medical teatment or surgical removal of tumor. | |||
Epinephrine secreting masses can cause episodic hypotension.<ref name="pmid8076587">{{cite journal| author=Bravo EL| title=Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. | journal=Endocr Rev | year= 1994 | volume= 15 | issue= 3 | pages= 356-68 | pmid=8076587 | doi=10.1210/edrv-15-3-356 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8076587 }}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Symptoms of pheochromocytoma include episodes of tachycardia, sweating and headaches.[1] Most patients don't have all symptoms.Less common symptoms include cardiomyopathy and episodic hypotension.[2]
History and Symptoms
The hallmark symptoms of a pheochromocytoma are those of sympathetic nervous system hyperactivity, symptoms usually subside in less than one hour and they may include:
- Palpitations especially in epinephrine producing tumors.[3]
- Anxiety often resembling that of a panic attack
- Sweating
- Headaches: occurs in 90 % of patients.
- paroxysmal attacks of hypertension but some patients have normal blood pressure.
- May be asymptomatic and discovered by incidence screening especially MEN patients.
Please note that not all patients with pheochromocytoma experience all classical symptoms.[4]
Less common symptoms include:
Cardiomyopathy: rare symptom due to catecholamine excess mimics takotsubo cardiomyopathy.[5] Patient improves after medical teatment or surgical removal of tumor.
Epinephrine secreting masses can cause episodic hypotension.[6]
References
- ↑ Stein PP, Black HR (1991). "A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience". Medicine (Baltimore). 70 (1): 46–66. PMID 1988766.
- ↑ Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N; et al. (2004). "Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients". Eur J Endocrinol. 150 (5): 681–6. PMID 15132724.
- ↑ Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
- ↑ Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N; et al. (2004). "Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients". Eur J Endocrinol. 150 (5): 681–6. PMID 15132724.
- ↑ Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
- ↑ Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.