Pheochromocytoma risk factors: Difference between revisions
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The most portent risk factors of pheochromocytoma are: | The most portent risk factors of pheochromocytoma are: | ||
=== '''Age:''' === | |||
Occurs in third to fifth decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.<sup>[[Pheochromocytoma epidemiology and demographics#cite note-cancergov-1|[1]]]</sup>. Hereditary tumors present at a younger age than sporadic. | |||
=== '''Family history:''' === | |||
Ten percent of pheochromocytomas are linked to hereditary causes: | |||
* '''Multiple endocrine neoplasia type 2''' is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma. | * '''Multiple endocrine neoplasia type 2''' is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma. | ||
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Overview
Pheochromocytoma is more common in people between 40 and 60 years old, men, people with family history of multiple endocrine neoplasia, von Hippel-Lindau disease, neurofibromatosis 1, hereditary paraganglioma syndromes.
Risk Factors
The most portent risk factors of pheochromocytoma are:
Age:
Occurs in third to fifth decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]. Hereditary tumors present at a younger age than sporadic.
Family history:
Ten percent of pheochromocytomas are linked to hereditary causes:
- Multiple endocrine neoplasia type 2 is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma.
MEN1 | MEN2 |
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- Von Hippel-Lindau disease can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys.
- Neurofibromatosis 1 (NF1) results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve.
- Hereditary paraganglioma syndromes are inherited disorders that result in either pheochromocytomas or paragangliomas.