Diabetes insipidus risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
*Genetic risk factors | *Genetic risk factors<ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref> | ||
*Polycystic Kidney Disease | *Polycystic Kidney Disease<ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref> | ||
*Pituitary Disorders | *Pituitary Disorders<ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref> | ||
*Hypothalamic injury | *Hypothalamic injury | ||
*Hypercalcemia | *Hypercalcemia | ||
*Head Tumors | *Head Tumors<ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref> | ||
*Pregnancy | *Pregnancy | ||
*Sickle cell disease | *Sickle cell disease | ||
*Amyloidosis | *Amyloidosis<ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref> | ||
*Male Gender- some types of nephrogenic DI have a male predisposition i.e DI caused by AQP2 mutations | *Male Gender- some types of nephrogenic DI have a male predisposition i.e DI caused by AQP2 mutations | ||
*Family History of Nephrogenic Diabetes Insipidus | *Family History of Nephrogenic Diabetes Insipidus | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
The risk factors in the development of diabetes insipidus vary depending on the type of DI caused. There are a few risk factors in the development of central DI which include genetic mutations, pituitary disorders, hypothalamic injury, head tumors. The most potent risk factor in the development of nephrogenic diabetes insipidus is lithium use as lithium has a very narrow therapeutic index of 0.4-0.8. Excessive water intake has been identified to be the only risk factor associated with psychogenic DI and pregnancy for gestational DI.[1]
Risk Factors
- Genetic risk factors[2]
- Polycystic Kidney Disease[3]
- Pituitary Disorders[4]
- Hypothalamic injury
- Hypercalcemia
- Head Tumors[5]
- Pregnancy
- Sickle cell disease
- Amyloidosis[6]
- Male Gender- some types of nephrogenic DI have a male predisposition i.e DI caused by AQP2 mutations
- Family History of Nephrogenic Diabetes Insipidus
- Excessive water consumption
- pregnancy
References
- ↑ Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF (2005). "Causes of reversible nephrogenic diabetes insipidus: a systematic review". Am. J. Kidney Dis. 45 (4): 626–37. PMID 15806465.
- ↑ Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M (2000). "Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants". J. Clin. Invest. 105 (7): 887–95. doi:10.1172/JCI8688. PMC 377482. PMID 10749568.
- ↑ Devonald MA, Karet FE (2004). "Renal epithelial traffic jams and one-way streets". J. Am. Soc. Nephrol. 15 (6): 1370–81. PMID 15153548.
- ↑ Bichet DG (2006). "Hereditary polyuric disorders: new concepts and differential diagnosis". Semin. Nephrol. 26 (3): 224–33. doi:10.1016/j.semnephrol.2006.02.004. PMID 16713495.
- ↑ van Lieburg AF, Knoers NV, Monnens LA (1999). "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus". J. Am. Soc. Nephrol. 10 (9): 1958–64. PMID 10477148.
- ↑ Bockenhauer D, Bichet DG (2015). "Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus". Nat Rev Nephrol. 11 (10): 576–88. doi:10.1038/nrneph.2015.89. PMID 26077742.