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Revision as of 16:06, 20 July 2017

Zollinger-Ellison syndrome Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]

Causes

  • The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
  • Causes of Hypergastrinemia: [2]


Causes of Hypergastrinemia
Appropriate hypergastrinemia
Atrophic gastritis with or without pernicious anemia
Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist)
Chronic renal failure
H pylori pangastritis
Vagotomy
Inappropriate hypergastrinemia
ZES (sporadic or associated with MEN-1)
Antral-predominant H pylori infection
Retained-antrum syndrome
Gastric-outlet obstruction
Small-bowel resection
Spurious hypergastrinemia
Nonfasting patient
Inaccurate assay

References

  1. 1.0 1.1 National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
  2. Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin Gastroenterol Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.

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