Hashimoto's thyroiditis classification: Difference between revisions
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==Overview== | ==Overview== | ||
On the basis of the etiology, Hashimoto's thyroiditis can be classified as primary or secondary types. Rarely, Hashimoto's thyroiditis can be categorized under the polyglandular | On the basis of the etiology, [[Hashimoto's thyroiditis]] can be classified as primary or secondary types. Rarely, [[Hashimoto's thyroiditis]] can be categorized under the [[Polyglandular autoimmune syndrome|polyglandular syndromes]]. | ||
==Classification== | ==Classification== | ||
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#Secondary | #Secondary | ||
#*Secondary HT is of more recent description. It includes the forms where an etiologic agent can be clearly identified. It is more commonly iatrogenic and induced by the administration of: | #*Secondary HT is of more recent description. It includes the forms where an etiologic agent can be clearly identified. It is more commonly iatrogenic and induced by the administration of: | ||
#**Immunomodulatory drugs (e.g, interferon-alpha.) | #**Immunomodulatory drugs (e.g, [[interferon-alpha]].) | ||
#**Monoclonal antibodies that block CTLA-4 | #**[[Monoclonal antibodies]] that block [[CTLA-4]] | ||
#**Cancer vaccines | #**Cancer vaccines | ||
In rare cases, Hashimoto's thyroiditis may be associated with other endocrine disorders caused by the immune system. On the basis of the involvement of other endocrine disease involvements, Hashimoto's thyroiditis may be classified under the polyglandular autoimmune syndromes. <ref name="pmid19411300">{{cite journal |vauthors=Kahaly GJ |title=Polyglandular autoimmune syndromes |journal=Eur. J. Endocrinol. |volume=161 |issue=1 |pages=11–20 |year=2009 |pmid=19411300 |doi=10.1530/EJE-09-0044 |url=}}</ref> | In rare cases, Hashimoto's thyroiditis may be associated with other endocrine disorders caused by the immune system. On the basis of the involvement of other endocrine disease involvements, Hashimoto's thyroiditis may be classified under the polyglandular autoimmune syndromes. <ref name="pmid19411300">{{cite journal |vauthors=Kahaly GJ |title=Polyglandular autoimmune syndromes |journal=Eur. J. Endocrinol. |volume=161 |issue=1 |pages=11–20 |year=2009 |pmid=19411300 |doi=10.1530/EJE-09-0044 |url=}}</ref> | ||
#Type 2 polyglandular autoimmune syndrome (PGA II). | #Type 2 polyglandular autoimmune syndrome (PGA II). | ||
#*Hashimoto's | #*[[Hashimoto's thyroiditis]]/[[hypothyroidism]] | ||
#*Adrenal insufficiency | #*[[Adrenal insufficiency]] | ||
#*Type 1 diabetes | #*[[Diabetes mellitus type 1|Type 1 diabetes]] | ||
#Type 1 polyglandular autoimmune syndrome (PGA I): | #Type 1 polyglandular autoimmune syndrome (PGA I): | ||
#*Hashimoto's disease/hypothyroidism | #*Hashimoto's disease/hypothyroidism | ||
Revision as of 18:55, 20 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
On the basis of the etiology, Hashimoto's thyroiditis can be classified as primary or secondary types. Rarely, Hashimoto's thyroiditis can be categorized under the polyglandular syndromes.
Classification
Hashimoto's thyroiditis can be classified on the basis of the etiology to the primary and secondary types as follows:[1]
- Primary
- Primary HT is the most common form of thyroiditis and comprises the cases that do not currently have identifiable causes. Primary HT encompasses a spectrum of six main types:
- Classic form
- Fibrous variant
- IgG4-related variant
- Juvenile form
- Hashitoxicosis
- Painless (or silent) thyroiditis
- Sporadic
- Postpartum
- Primary HT is the most common form of thyroiditis and comprises the cases that do not currently have identifiable causes. Primary HT encompasses a spectrum of six main types:
- Secondary
- Secondary HT is of more recent description. It includes the forms where an etiologic agent can be clearly identified. It is more commonly iatrogenic and induced by the administration of:
- Immunomodulatory drugs (e.g, interferon-alpha.)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Secondary HT is of more recent description. It includes the forms where an etiologic agent can be clearly identified. It is more commonly iatrogenic and induced by the administration of:
In rare cases, Hashimoto's thyroiditis may be associated with other endocrine disorders caused by the immune system. On the basis of the involvement of other endocrine disease involvements, Hashimoto's thyroiditis may be classified under the polyglandular autoimmune syndromes. [2]
- Type 2 polyglandular autoimmune syndrome (PGA II).
- Type 1 polyglandular autoimmune syndrome (PGA I):
- Hashimoto's disease/hypothyroidism
- Adrenal insufficiency
- Fungal infections of the mouth and nails
- Hypoparathyroidism
References
- ↑ Caturegli P, De Remigis A, Rose NR (2014). "Hashimoto thyroiditis: clinical and diagnostic criteria". Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.
- ↑ Kahaly GJ (2009). "Polyglandular autoimmune syndromes". Eur. J. Endocrinol. 161 (1): 11–20. doi:10.1530/EJE-09-0044. PMID 19411300.