Differentiating Hashimoto's thyroiditis from other diseases

Hashimoto's thyroiditis Microchapters
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Differentiating Hashimoto's Thyroiditis from other Diseases
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differentiating Hashimoto's Thyroiditis from other Diseases

• Lymphoma and depression may present similarly to Hashimoto's thyroiditis.

Conditions Causes Age at onset Pathological findings Diagnostic approach Hashimoto's thyroiditis Autoimmune All ages, peak at 30-50 Lymphocytic infiltration Germinal centers Fibrosis (in some variants) Increased TSH (hypothyroidism) TPO antibodies present in high titer Usually decreased I-123 uptake Painful subacute thyroiditis Unknown 20-60 Giant cells Granulomas Increased TSH (hypothyroidism) and/or Decreased TSH (Thyrotoxicosis) TPO antibodies absent or very low titer I-123 uptake decreased Riedels thyroiditis Unknown 30-60 Dense fibrosis Normal TSH (euthyroidism) TPO antibodies present I-123 uptake decreased or normal Suppurative thyroiditis Infection Children, 20-40 Abscess formation Normal TSH (euthyroidism) TPO antibodies absent I-123 uptake normal References