Pheochromocytoma causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Pheochromocytoma}} | {{Pheochromocytoma}} | ||
{{CMG}} | {{CMG}} {{AE}} {{AAM}} {{MAD}} | ||
==Overview== | ==Overview== | ||
Pheochromocytoma develops in called chromaffin cells, found in adrenal medulla which secrete adrenaline, noradrenaline. | Pheochromocytoma develops in called chromaffin cells, found in adrenal medulla which secrete adrenaline, noradrenaline. | ||
Familial pheochromocytoma may be caused by a mutation of either ''[[VHL]]'', ''RET'', ''NF1'', ''[[SDHB]]'' or ''[[SDHD]]'' genes. | Familial pheochromocytoma may be caused by a mutation of either ''[[VHL]]'', ''RET'', ''NF1'', ''[[SDHB]]'' or ''[[SDHD]]'' genes. | ||
==Causes== | ==Causes== | ||
* Pheochromocytoma develops in called [[chromaffin cells]], found in adrenal medulla. | * Pheochromocytoma develops in called [[chromaffin cells]], found in adrenal medulla. | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 14:00, 21 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
Pheochromocytoma develops in called chromaffin cells, found in adrenal medulla which secrete adrenaline, noradrenaline. Familial pheochromocytoma may be caused by a mutation of either VHL, RET, NF1, SDHB or SDHD genes.
Causes
- Pheochromocytoma develops in called chromaffin cells, found in adrenal medulla.
- Chromaffin cells typically secrete adrenaline, noradrenaline and dopamine.
- These hormones are sympathetic stimulants.
- Pheochromocytoma results in the irregular and excessive release of these hormones causing hypertension and tachycardia. Approximately 10% are located in chromaffin tissue outside of the adrenal gland, The most common extradrenal locations are the abdomen and thorax
- Approximately 10% of tumors are malignant. Commonest sites of spread are base of skull, head and neck.
- Genetic base of pheochromocytoma depends on 2 clusters: cluster 1 tumors are noradrenergic. Cluster 2 tumors are adrenergic.[1]
| Cluster 1 | Cluster 2 |
|---|---|
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References
- ↑ King KS, Pacak K (2014). "Familial pheochromocytomas and paragangliomas". Mol Cell Endocrinol. 386 (1–2): 92–100. doi:10.1016/j.mce.2013.07.032. PMC 3917973. PMID 23933153.