Polycystic ovary syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

The underlying defect in patients with PCOS remains unknown, but abnormal gonadotropin dynamics are mainly responsible for the development of polycystic ovary syndrome. Most researchers think that more than one factor could play a role in developing PCOS.

Causes

The underlying defect in patients with PCOS remains unknown, but abnormal gonadotropin dynamics are mainly responsible for the development of polycystic ovary syndrome. Most researchers think that more than one factor could play a role in developing PCOS.

• Increased gonadotropin-releasing hormone secretion in the pituitary gland results in increased secretion of serum luteinizing hormone (LH) and an elevated LH/follicle-stimulating hormone (FSH) ratio.
• Hypersecretion of LH results in increased ovarian androgen production, leading to arrest of follicular development with follicular atresia; multiple cysts form in the ovaries, largely without ovulation
• Genes are thought to be another factor.

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