African trypanosomiasis history and symptoms: Difference between revisions
Jump to navigation
Jump to search
| Line 3: | Line 3: | ||
{{CMG}}; {{AOEIC}} Pilar Almonacid {{ADG}} | {{CMG}}; {{AOEIC}} Pilar Almonacid {{ADG}} | ||
==Overview== | ==Overview== | ||
The clinical course of human African trypanosomiasis has two stages. In the first stage, the [[Parasites|parasite]] is found in the peripheral circulation | The clinical course of human African trypanosomiasis has two stages. In the first stage, the [[Parasites|parasite]] is found in the peripheral circulation but it has not yet invaded the [[central nervous system]]. Once the [[Parasites|parasite]] crosses the [[blood-brain barrier]] and infects the [[central nervous system]], the [[disease]] enters the second stage. The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the [[Parasites|parasite]] (T. b. rhodesiense or T. b. gambiense) is causing the infection. However, infection with either form will eventually lead to coma and death if not treated.<ref name="pmid19833383">{{cite journal |vauthors=Brun R, Blum J, Chappuis F, Burri C |title=Human African trypanosomiasis |journal=Lancet |volume=375 |issue=9709 |pages=148–59 |year=2010 |pmid=19833383 |doi=10.1016/S0140-6736(09)60829-1 |url=}}</ref><ref name="pmid17582444">{{cite journal |vauthors=Masocha W, Rottenberg ME, Kristensson K |title=Migration of African trypanosomes across the blood-brain barrier |journal=Physiol. Behav. |volume=92 |issue=1-2 |pages=110–4 |year=2007 |pmid=17582444 |doi=10.1016/j.physbeh.2007.05.045 |url=}}</ref><ref name="pmid18261232">{{cite journal |vauthors=Checchi F, Filipe JA, Haydon DT, Chandramohan D, Chappuis F |title=Estimates of the duration of the early and late stage of gambiense sleeping sickness |journal=BMC Infect. Dis. |volume=8 |issue= |pages=16 |year=2008 |pmid=18261232 |pmc=2259357 |doi=10.1186/1471-2334-8-16 |url=}}</ref><ref name="pmid9557424">{{cite journal |vauthors=Odiit M, Kansiime F, Enyaru JC |title=Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda |journal=East Afr Med J |volume=74 |issue=12 |pages=792–5 |year=1997 |pmid=9557424 |doi= |url=}}</ref> | ||
==Symptoms== | ==Symptoms== | ||
Revision as of 16:37, 25 July 2017
|
African trypanosomiasis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
African trypanosomiasis history and symptoms On the Web |
|
American Roentgen Ray Society Images of African trypanosomiasis history and symptoms |
|
Risk calculators and risk factors for African trypanosomiasis history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Pilar Almonacid Aditya Ganti M.B.B.S. [2]
Overview
The clinical course of human African trypanosomiasis has two stages. In the first stage, the parasite is found in the peripheral circulation but it has not yet invaded the central nervous system. Once the parasite crosses the blood-brain barrier and infects the central nervous system, the disease enters the second stage. The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the parasite (T. b. rhodesiense or T. b. gambiense) is causing the infection. However, infection with either form will eventually lead to coma and death if not treated.[1][2][3][4]
Symptoms
Symptoms of African trypanosomiasis include:[1][2][3][4]
| Stages of infection | Symptoms |
|---|---|
| Systemic | |
| First stage (hemo-lyphatic stage) | |
| Second stage (neurological or meningoencephalic stage) |
|
The subspecies that cause African trypanosomiasis have different rates of disease progression, and the clinical features depend on which form of the parasite (T. b. rhodesiense or T. b. gambiense) is causing the infection.
| Disease | Pathogen | Geographic
distrubution |
Progression | Symptoms | |
|---|---|---|---|---|---|
| First stage | Second stage | ||||
| East African sleeping sickness | Trypanosoma brucei rhodesiense | East and Southeast Africa | Rapid
(1-2 weeks) |
|
|
| West African sleeping sickness | Trypanosoma brucei gambiense | West and Central Africa | Slow
(1-2 years) |
|
|
References
- ↑ 1.0 1.1 Brun R, Blum J, Chappuis F, Burri C (2010). "Human African trypanosomiasis". Lancet. 375 (9709): 148–59. doi:10.1016/S0140-6736(09)60829-1. PMID 19833383.
- ↑ 2.0 2.1 Masocha W, Rottenberg ME, Kristensson K (2007). "Migration of African trypanosomes across the blood-brain barrier". Physiol. Behav. 92 (1–2): 110–4. doi:10.1016/j.physbeh.2007.05.045. PMID 17582444.
- ↑ 3.0 3.1 Checchi F, Filipe JA, Haydon DT, Chandramohan D, Chappuis F (2008). "Estimates of the duration of the early and late stage of gambiense sleeping sickness". BMC Infect. Dis. 8: 16. doi:10.1186/1471-2334-8-16. PMC 2259357. PMID 18261232.
- ↑ 4.0 4.1 Odiit M, Kansiime F, Enyaru JC (1997). "Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda". East Afr Med J. 74 (12): 792–5. PMID 9557424.