Pheochromocytoma risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Pheochromocytoma is more common in people between 40 and 60 years old, men, people with family history of multiple endocrine neoplasias, von Hippel-Lindau disease, neurofibromatosis 1, hereditary paraganglioma syndromes. | Pheochromocytoma is more common in people between 40 and 60 years old, men, people with family history of [[Multiple endocrine neoplasia|multiple endocrine neoplasias,]] [[von Hippel-Lindau disease]], [[Neurofibromatosis type I|neurofibromatosis 1]], [[Paraganglioma|hereditary paraganglioma syndromes]]. | ||
==Risk Factors== | ==Risk Factors== | ||
The most potent risk factors of pheochromocytoma are: | The most potent risk factors of pheochromocytoma are: | ||
=== '''Age | === '''Age''' === | ||
Occurs in third to fifth decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc</ref> | Occurs in third to fifth decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc</ref> | ||
Hereditary tumors present at a younger age than sporadic. | Hereditary tumors present at a younger age than sporadic. | ||
=== '''Family history | === '''Family history''' === | ||
Ten percent of pheochromocytomas are linked to hereditary causes: | Ten percent of pheochromocytomas are linked to hereditary causes: | ||
* '''Multiple endocrine neoplasia type 2''' is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma. | * '''Multiple endocrine neoplasia type 2''' is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma. | ||
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* Medullary thyroid cancer | * [[Medullary thyroid cancer]] | ||
* Pheochromocytoma | * [[Pheochromocytoma]] | ||
* Primary hyperparathyroidism | * [[Primary hyperparathyroidism]] | ||
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* Medullary thyroid cancer | * [[Medullary thyroid cancer]] | ||
* Pheochromocytoma | * [[Pheochromocytoma]] | ||
* Mucosal neuromas | * [[Neuroma|Mucosal neuromas]] | ||
* Marfanoid habitus | * [[Marfan's syndrome|Marfanoid habitus]] | ||
|} | |} | ||
* '''Von Hippel-Lindau disease''' can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys. | * '''[[Von Hippel-Lindau disease]]''' can result in tumors at multiple sites, including the central nervous system, endocrine system, [[pancreas]] and kidneys. | ||
* '''Neurofibromatosis 1 | * '''[[Neurofibromatosis type I|Neurofibromatosis 1]]''' results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve. | ||
* '''Hereditary paraganglioma syndromes''' are inherited disorders that result in either pheochromocytomas or paragangliomas. | * '''[[Paraganglioma|Hereditary paraganglioma syndromes]]''' are inherited disorders that result in either pheochromocytomas or [[Paraganglioma|paragangliomas.]] | ||
==References== | ==References== | ||
Revision as of 16:02, 31 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Pheochromocytoma is more common in people between 40 and 60 years old, men, people with family history of multiple endocrine neoplasias, von Hippel-Lindau disease, neurofibromatosis 1, hereditary paraganglioma syndromes.
Risk Factors
The most potent risk factors of pheochromocytoma are:
Age
Occurs in third to fifth decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]
Hereditary tumors present at a younger age than sporadic.
Family history
Ten percent of pheochromocytomas are linked to hereditary causes:
- Multiple endocrine neoplasia type 2 is a hereditary condition associated with medullary thyroid cancer and other types of cancer, including pheochromocytoma.
| MEN1 | MEN2 |
|---|---|
- Von Hippel-Lindau disease can result in tumors at multiple sites, including the central nervous system, endocrine system, pancreas and kidneys.
- Neurofibromatosis 1 results in multiple tumors in the skin (neurofibromas), pigmented skin spots and tumors of the optic nerve.
- Hereditary paraganglioma syndromes are inherited disorders that result in either pheochromocytomas or paragangliomas.
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc