De Quervain's thyroiditis pathophysiology

De Quervain's thyroiditis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating De Quervain's thyroiditis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary prevention
Secondary prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The exact pathogenesis of de Quervain's thyroiditis is unclear. It is proposed that cytotoxic T cell recognition of viral and cell antigens presentation in a complex leads to the thyroid follicular cell damage which is responsible for the pathogenesis of de Quervain's thyroiditis. De Quervain's thyroiditis is usually preceded by a viral prodrome and also have a genetic predisposition. HLA B35 and HLA B15/62 are associated with de Quervain's thyroiditis.

Pathophysiology

Pathogenesis

The exact pathogenesis of de Quervain's thyroiditis is unclear. Cytotoxic T cell recognition of viral and cell antigens presented in a complex leading to thyroid follicular cell damage has been proposed as the pathogenesis of de Quervain's thyroiditis. De Quervain's thyroiditis is usually preceded by a viral prodrome. Various viral infections are associated with the de Quervain's thyroiditis including mumps, adenovirus, Epstein–Barr virus, coxsackievirus, cytomegalovirus, influenza, echovirus, and enterovirus.

Genetics

• De Quervain's thyroiditis is associated with the histocompatibility antigen (HLA) B35.
• In some cases of De Quervain's thyroiditis HLA B15/62 positivity was also reported.

Pathology

The primary pathology of de Quervain's thyroiditis is:

• Destruction of the follicular epithelium
• Loss of the follicular integrity