Glucagonoma differential diagnosis: Difference between revisions
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==Differentiating Glucagonoma from other Disease== | ==Differentiating Glucagonoma from other Disease== | ||
Glucagonoma must be differentiated from certain skin lesions and other causes of hyperglucagonemia:<ref>Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. accessed on October 10, 2015</ref><ref name="pmid25152626">{{cite journal| author=Fang S, Li S, Cai T| title=Glucagonoma syndrome: a case report with focus on skin disorders. | journal=Onco Targets Ther | year= 2014 | volume= 7 | issue= | pages= 1449-53 | pmid=25152626 | doi=10.2147/OTT.S66285 | pmc=PMC4140234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25152626 }} </ref> | Glucagonoma must be differentiated from certain skin lesions in which necrolytic migratory erythema can be found and other causes of hyperglucagonemia:<ref>Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. accessed on October 10, 2015</ref><ref name="pmid25152626">{{cite journal| author=Fang S, Li S, Cai T| title=Glucagonoma syndrome: a case report with focus on skin disorders. | journal=Onco Targets Ther | year= 2014 | volume= 7 | issue= | pages= 1449-53 | pmid=25152626 | doi=10.2147/OTT.S66285 | pmc=PMC4140234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25152626 }} </ref> | ||
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! rowspan="2" |Disease | |||
! colspan="3" |Clinical Picture | |||
! rowspan="2" |Investigations | |||
! rowspan="2" |Pictures | |||
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!History | |||
!Symptoms | |||
!Signs | |||
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|Glucagonoma | |||
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* The first peak for the development of psoriasis occurs between 20 years to 35 years and the second peak is between 40 years to 65 years of life. | |||
* Patients with early disease onset often have a positive family history of psoriasis, frequent association with [[histocompatibility]] [[antigen]] (HLA)- Cw6, and more severe disease. Those with onset after the age of 40 usually have a negative family history and a normal frequency of the HLA- Cw6 allele.<sup>[[Psoriasis history and symptoms#cite note-pmid1390163-2|[2]]]</sup> | |||
* A typical patient of psoriasis will present with a history of a long-term [[erythematous]] scaly area with [[ocular]] and [[joint]] involvement depending upon the clinical subtype and chronicity of the disease. There may be multiple relapses and remissions. | |||
* Past medical history of the patient may include [[viral]] or [[bacterial]] infection, [[Diabetes mellitus|diabetes]], [[hypertension]], [[chronic kidney disease]] and/or [[obesity]] due to an association of psoriasis with these conditions.<sup>[[Psoriasis history and symptoms#cite note-pmid24790463-3|[3]]]</sup> | |||
* A social history of the patient may indicate smoking, excessive alcohol consumption and/or a recent stressful event if life associated with an acute exacerbation of psoriasis.<sup>[[Psoriasis history and symptoms#cite note-pmid13901632-4|[4]]]</sup> | |||
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|[[Liver cirrhosis|End-stage liver disease]] | |||
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|[[Pemphigus foliaceus]] | |||
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|[[Psoriasis|Pustular psoriasis]] | |||
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|[[Acrodermatitis enteropathica]] | |||
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|[[Pellagra]] | |||
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|[[eczema|Chronic eczema]] | |||
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|[[kwashiorkor]] | |||
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==References== | ==References== | ||
Revision as of 14:39, 3 August 2017
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Glucagonoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Glucagonoma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Glucagonoma differential diagnosis |
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Risk calculators and risk factors for Glucagonoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Glucagonoma must be differentiated from certain skin lesions (acrodermatitis enteropathica, psoriasis, pellagra, eczema) and other causes of hyperglucagonemia (infection, diabetes mellitus, Cushing syndrome, renal failure, acute pancreatitis, severe stress, and prolonged fasting).
Differentiating Glucagonoma from other Disease
Glucagonoma must be differentiated from certain skin lesions in which necrolytic migratory erythema can be found and other causes of hyperglucagonemia:[1][2]
| Disease | Clinical Picture | Investigations | Pictures | ||
|---|---|---|---|---|---|
| History | Symptoms | Signs | |||
| Glucagonoma |
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| End-stage liver disease | |||||
| Pemphigus foliaceus | |||||
| Pustular psoriasis | |||||
| Acrodermatitis enteropathica | |||||
| Pellagra | |||||
| Chronic eczema | |||||
| kwashiorkor | |||||
References
- ↑ Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. accessed on October 10, 2015
- ↑ Fang S, Li S, Cai T (2014). "Glucagonoma syndrome: a case report with focus on skin disorders". Onco Targets Ther. 7: 1449–53. doi:10.2147/OTT.S66285. PMC 4140234. PMID 25152626.