Lyme disease differential diagnosis: Difference between revisions
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''Borreliosis (Lyme Disease)'' <ref name="Lyme CDC”">Lyme Disease Information for HealthCare Professionals. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/lyme/healthcare/index.html Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Borreliosis]] ([[Lyme disease|Lyme Disease]])'' <ref name="Lyme CDC”">Lyme Disease Information for HealthCare Professionals. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/lyme/healthcare/index.html Accessed on December 30, 2015</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Borrelia burgdorferi'' sensu lato complex and ''B. mayonii'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Borrelia burgdorferi]]'' sensu lato complex and ''[[Borrelia mayonii|B. mayonii]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[I. scapularis]]'', ''[[I. pacificus]]'', ''[[I. ricinus]]'', and ''I. persulcatus'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[I. scapularis]]'', ''[[I. pacificus]]'', ''[[I. ricinus]]'', and ''I. persulcatus'' | ||
| style="background: #DCDCDC; padding: 5px;" |[[Erythema migrans]], flu-like illness([[fatigue]], [[fever]]), [[arthritis]] | | style="background: #DCDCDC; padding: 5px;" |[[Erythema migrans]], flu-like illness([[fatigue]], [[fever]]), [[Lyme arthritis]], [[neuroborreliosis]], and [[carditis]]. | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" rowspan="2" | ''[[Relapsing Fever]]'' <ref name="TBRF CDC”">Relapsing Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/relapsing-fever/ Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" rowspan="2" | ''[[Relapsing Fever]]'' <ref name="TBRF CDC”">Relapsing Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/relapsing-fever/ Accessed on December 30, 2015</ref> | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" |Louse-borne relapsing fever (LBRF) : | | style="background: #F5F5F5; padding: 5px; text-align: center;" |Louse-borne relapsing fever (LBRF) : | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Borrelia recurrentis'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Borrelia recurrentis]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" |''[[Pediculus humanus]]'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" |''[[Pediculus humanus]]'' | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Rocky Mountain Spotted Fever]]'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Rocky Mountain Spotted Fever]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Rickettsia | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Rickettsia rickettsii]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Dermacentor | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Dermacentor variabilis]]'', [[Dermacentor andersoni]] | ||
| style="background: #DCDCDC; padding: 5px;" | [[Fever]], [[altered mental status]], [[myalgia]], [[rash]], and [[headaches]]. | | style="background: #DCDCDC; padding: 5px;" | [[Fever]], [[altered mental status]], [[myalgia]], [[rash]], and [[headaches]]. | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Helvetica Spotted Fever]]'' <ref name="RMSF CDC”">Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/ Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Helvetica Spotted Fever]]'' <ref name="RMSF CDC”">Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/ Accessed on December 30, 2015</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Rickettsia | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Rickettsia helvetica'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Ixodes | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Ixodes ricinus]]'' | ||
| style="background: #DCDCDC; padding: 5px;" | [[Rash]]: spotted, red dots. Respiratory symptoms ([[dyspnea]], [[cough]]), [[myalgia|muscle pain]], and [[headaches]]. | | style="background: #DCDCDC; padding: 5px;" | [[Rash]]: spotted, red dots. Respiratory symptoms ([[dyspnea]], [[cough]]), [[myalgia|muscle pain]], and [[headaches]]. | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Ehrlichiosis Anaplasmosis]]'' <ref name="Ehrlichiosis CDC”">Disease index General Information (2015). http://www.cdc.gov/parasites/babesiosis/health_professionals/index.html Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Ehrlichiosis Anaplasmosis|Ehrlichiosis (Anaplasmosis)]]'' <ref name="Ehrlichiosis CDC”">Disease index General Information (2015). http://www.cdc.gov/parasites/babesiosis/health_professionals/index.html Accessed on December 30, 2015</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Ehrlichia | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Ehrlichia chaffeensis, Ehrlichia ewingii'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Amblyomma americanum]], [[Ixodes scapularis]]'' | ||
| style="background: #DCDCDC; padding: 5px;" | [[Fever]], [[headache]], [[chills]], [[malaise]], [[myalgia|muscle pain]], [[nausea]], [[confusion]], [[conjunctivitis]], or [[rash]] (60% in children and 30% in adults). | | style="background: #DCDCDC; padding: 5px;" | [[Fever]], [[headache]], [[chills]], [[malaise]], [[myalgia|muscle pain]], [[nausea]], [[confusion]], [[conjunctivitis]], or [[rash]] (60% in children and 30% in adults). | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Tularemia]]'' <ref name="Tulameria CDC”">Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). \http://www.cdc.gov/tularemia/index.html Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | ''[[Tularemia]]'' <ref name="Tulameria CDC”">Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). \http://www.cdc.gov/tularemia/index.html Accessed on December 30, 2015</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Francisella | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Francisella tularensis]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | [[Dermacentor andersoni|''Dermacentor andersoni'']]'', [[Dermacentor variabilis]]'' | ||
| style="background: #DCDCDC; padding: 5px;" | Ulceroglandular, glandular, oculoglandular, oroglandular, pneumonic, typhoidal. | | style="background: #DCDCDC; padding: 5px;" | Ulceroglandular, [[glandular]], oculoglandular, oroglandular, pneumonic, typhoidal. | ||
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| style="font-size: 14px; background: #7d7d7d; text-align: center;" colspan="2" | {{fontcolor|#FFF|'''Viral Infection'''}} | | style="font-size: 14px; background: #7d7d7d; text-align: center;" colspan="2" | {{fontcolor|#FFF|'''Viral Infection'''}} | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Colorado tick fever|Colorado Tick Fever]] <ref name="GenTickDis CDC”">General Tick Deisease Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/coloradotickfever/index.html Accessed on December 30, 2015</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Colorado tick fever|Colorado Tick Fever]] <ref name="GenTickDis CDC”">General Tick Deisease Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/coloradotickfever/index.html Accessed on December 30, 2015</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''CTF virus'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''CTF virus'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Dermacentor andersoni'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Dermacentor andersoni]]'' | ||
| style="background: #DCDCDC; padding: 5px;" |Common symptoms include [[fever]], [[chills]], [[headache]], [[body aches]], and [[lethargy]]. Other symptoms associated with the disease include [[sore throat]], [[abdominal pain]], [[vomiting]], and a skin [[rash]]. A biphasic [[fever]] is a hallmark of Colorado Tick Fever and presents in nearly 50% of infected patients. | | style="background: #DCDCDC; padding: 5px;" |Common symptoms include [[fever]], [[chills]], [[headache]], [[body aches]], and [[lethargy]]. Other symptoms associated with the disease include [[sore throat]], [[abdominal pain]], [[vomiting]], and a skin [[rash]]. A biphasic [[fever]] is a hallmark of Colorado Tick Fever and presents in nearly 50% of infected patients. | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Crimean-Congo Hemmoragic Fever|Crimean-Congo Hemorrhagic Fever]] | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Crimean-Congo Hemmoragic Fever|Crimean-Congo Hemorrhagic Fever]] | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''CCHF virus'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[CCHF virus]]'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '' Hyalomma marginatum'', ''Rhipicephalus bursa'' | | style="background: #F5F5F5; padding: 5px; text-align: center;" | '' Hyalomma marginatum'', ''Rhipicephalus bursa'' | ||
| style="background: #DCDCDC; padding: 5px;" |Initially infected patients will likely feel a few of the following symptoms: [[headache]], high [[fever]], [[back pain|back]] and [[joint pain]], [[stomach pain]], [[vomiting]], flushed face, red throat [[petechiae]] of the [[palate]], and potentially changes in mood as well as sensory perception. | | style="background: #DCDCDC; padding: 5px;" |Initially infected patients will likely feel a few of the following symptoms: [[headache]], high [[fever]], [[back pain|back]] and [[joint pain]], [[stomach pain]], [[vomiting]], flushed face, red throat [[petechiae]] of the [[palate]], and potentially changes in mood as well as sensory perception. | ||
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| style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Babesiosis]] <ref name="Babesiosis CDC”">Babesiosis. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/parasites/babesiosis/disease.htmlAccessed December 8, 2015.</ref> | | style="background: #F5F5F5; padding: 5px; text-align: center;" colspan="2" | [[Babesiosis]] <ref name="Babesiosis CDC”">Babesiosis. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/parasites/babesiosis/disease.htmlAccessed December 8, 2015.</ref> | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''Babesia microti, | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Babesia microti]], [[Babesia divergens]], Babesia equi'' | ||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Ixodes scapularis | | style="background: #F5F5F5; padding: 5px; text-align: center;" | ''[[Ixodes scapularis]], ''[[I. pacificus]] | ||
| style="background: #DCDCDC; padding: 5px;" |Non-specific flu-like symptoms. | | style="background: #DCDCDC; padding: 5px;" |Non-specific flu-like symptoms. | ||
Revision as of 20:50, 7 August 2017
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Lyme disease differential diagnosis On the Web |
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American Roentgen Ray Society Images of Lyme disease differential diagnosis |
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Risk calculators and risk factors for Lyme disease differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lyme disease must be differentiated from babesiosis, leptospirosis, mononucleosis, viral meningitis, and chronic diseases such as SLE, fibromyalgia, and chronic fatigue syndrome.
Differentiating Lyme disease from other tick-borne diseases
Lyme disease must be differentiated from other diseases that may cause arthralgia, fever, and skin manifestations and that are associated with a history of tick exposure.
| Disease | Organism | Vector | Symptoms | |
|---|---|---|---|---|
| Bacterial Infection | ||||
| Borreliosis (Lyme Disease) [1] | Borrelia burgdorferi sensu lato complex and B. mayonii | I. scapularis, I. pacificus, I. ricinus, and I. persulcatus | Erythema migrans, flu-like illness(fatigue, fever), Lyme arthritis, neuroborreliosis, and carditis. | |
| Relapsing Fever [2] | Tick-borne relapsing fever (TBRF): | Borrelia duttoni, Borrelia hermsii, and Borrelia parkerii | Ornithodoros species | Consistently documented high fevers, flu-like illness, headaches, muscular soreness or joint pain, altered mental status, painful urination, rash, and rigors. |
| Louse-borne relapsing fever (LBRF) : | Borrelia recurrentis | Pediculus humanus | ||
| Typhus (Rickettsia) | ||||
| Rocky Mountain Spotted Fever | Rickettsia rickettsii | Dermacentor variabilis, Dermacentor andersoni | Fever, altered mental status, myalgia, rash, and headaches. | |
| Helvetica Spotted Fever [3] | Rickettsia helvetica | Ixodes ricinus | Rash: spotted, red dots. Respiratory symptoms (dyspnea, cough), muscle pain, and headaches. | |
| Ehrlichiosis (Anaplasmosis) [4] | Ehrlichia chaffeensis, Ehrlichia ewingii | Amblyomma americanum, Ixodes scapularis | Fever, headache, chills, malaise, muscle pain, nausea, confusion, conjunctivitis, or rash (60% in children and 30% in adults). | |
| Tularemia [5] | Francisella tularensis | Dermacentor andersoni, Dermacentor variabilis | Ulceroglandular, glandular, oculoglandular, oroglandular, pneumonic, typhoidal. | |
| Viral Infection | ||||
| Tick-borne meningoencephalitis [6] | TBEV virus | Ixodes scapularis, I. ricinus, I. persulcatus | Early Phase: Non-specific symptoms including fever, malaise, anorexia, muscle pains, headaches, nausea, and vomiting. Second Phase: Meningitis symptoms, headache, stiff neck, encephalitis, drowsiness, sensory disturbances, and potential paralysis. | |
| Colorado Tick Fever [7] | CTF virus | Dermacentor andersoni | Common symptoms include fever, chills, headache, body aches, and lethargy. Other symptoms associated with the disease include sore throat, abdominal pain, vomiting, and a skin rash. A biphasic fever is a hallmark of Colorado Tick Fever and presents in nearly 50% of infected patients. | |
| Crimean-Congo Hemorrhagic Fever | CCHF virus | Hyalomma marginatum, Rhipicephalus bursa | Initially infected patients will likely feel a few of the following symptoms: headache, high fever, back and joint pain, stomach pain, vomiting, flushed face, red throat petechiae of the palate, and potentially changes in mood as well as sensory perception. | |
| Protozoan Infection | ||||
| Babesiosis [8] | Babesia microti, Babesia divergens, Babesia equi | Ixodes scapularis, I. pacificus | Non-specific flu-like symptoms. | |
Differentiating Lyme disease from other diseases
- Allergic reaction to the tick
- Babesiosis
- Chronic fatigue syndrome (CFS)
- Depression
- Fibromyalgia
- Human granulocytic anaplasmosis (HGA)
- Leptospirosis
- Mononucleosis
- Other insect bites
- Reiter's syndrome
- Rheumatoid arthritis
- Scleroderma
- Systemic lupus erythematosus (SLE)
- Tick-borne diseases
- Viral meningitis[9]
References
- ↑ Lyme Disease Information for HealthCare Professionals. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/lyme/healthcare/index.html Accessed on December 30, 2015
- ↑ Relapsing Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/relapsing-fever/ Accessed on December 30, 2015
- ↑ Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/ Accessed on December 30, 2015
- ↑ Disease index General Information (2015). http://www.cdc.gov/parasites/babesiosis/health_professionals/index.html Accessed on December 30, 2015
- ↑ Rocky Mountain Spotted Fever Information. Centers for Disease Control and Prevention (2015). \http://www.cdc.gov/tularemia/index.html Accessed on December 30, 2015
- ↑ General Disease Information (TBE). Centers for Disease Control and Prevention (2015). http://www.cdc.gov/vhf/tbe/ Accessed on December 30, 2015
- ↑ General Tick Deisease Information. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/coloradotickfever/index.html Accessed on December 30, 2015
- ↑ Babesiosis. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/parasites/babesiosis/disease.htmlAccessed December 8, 2015.
- ↑ "Lyme Disease Diseases With Similar Symptoms - Lyme Disease Health Information - NY Times Health". Retrieved 2013-03-14.