Psoriasis Screening: Difference between revisions
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==Screening== | ==Screening== | ||
===Genetic screening for psoriasis=== | ===Genetic screening for psoriasis=== | ||
*The strong | *The strong involvement of genetics in the development of psoriasis allows for screening for this disease via genetic testing. | ||
*[[HLA]] Class I antigens ([[HLA-B13]], HLA-B57, HLA-B39, HLA-Cw6, HLACw7) have been | *[[HLA]] Class I antigens ([[HLA-B13]], HLA-B57, HLA-B39, HLA-Cw6, HLACw7) have been shown to be associated with psoriasis and [[psoriatic arthritis]].<ref name="pmid12508382">{{cite journal |vauthors=Gladman DD, Farewell VT |title=HLA studies in psoriatic arthritis: current situation and future needs |journal=J. Rheumatol. |volume=30 |issue=1 |pages=4–6 |year=2003 |pmid=12508382 |doi= |url=}}</ref> | ||
*[[HLA-B13]], -B16, and its splits -B38 and -B39, B17, and Cw6 are associated with psoriasis, with or without arthritis. | *[[HLA-B13]], -B16, and its splits -B38 and -B39, B17, and Cw6 are associated with psoriasis, with or without arthritis. | ||
*Early screening combined with early treatment can help prevent disease progression. | *Early screening combined with early treatment can help prevent disease progression. | ||
*A sample for [[genetic testing]] is usually taken from a cheek swab. | *A sample for [[genetic testing]] is usually taken from a cheek swab. | ||
===Psoriasis screening tool (PST)=== | ===Psoriasis screening tool (PST)=== | ||
*The Psoriasis Screening Tool (PST) consists of eight | *The Psoriasis Screening Tool (PST) consists of eight questions with a "yes" or "no" response with typical images of [[skin]], [[Nail (anatomy)|nail]], and [[scalp]] changes in psoriasis included with respective questions.<ref name="pmid19566664">{{cite journal |vauthors=Dominguez PL, Assarpour A, Kuo H, Holt EW, Tyler S, Qureshi AA |title=Development and pilot-testing of a psoriasis screening tool |journal=Br. J. Dermatol. |volume=161 |issue=4 |pages=778–84 |year=2009 |pmid=19566664 |doi=10.1111/j.1365-2133.2009.09247.x |url=}}</ref> | ||
*The questions distinguish individuals with psoriasis from individuals without the disease in an [[Outpatient|outpatient setting]]. | *The questions distinguish individuals with psoriasis from individuals without the disease in an [[Outpatient|outpatient setting]]. | ||
*A similar questionnaire exists for [[psoriatic arthritis]], called the Psoriasis Epidemiology Screening Tool (PEST).<ref name="urlPsoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology">{{cite web |url=http://www.jrheum.org/content/38/3/551.long |title=Psoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology |format= |work= |accessdate=}}</ref> | *A similar questionnaire exists for [[psoriatic arthritis]], called the Psoriasis Epidemiology Screening Tool (PEST).<ref name="urlPsoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology">{{cite web |url=http://www.jrheum.org/content/38/3/551.long |title=Psoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology |format= |work= |accessdate=}}</ref> | ||
Revision as of 02:11, 8 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
There are no established guidelines for screening for psoriasis among the general population. Screening methods include the psoriasis screening tool (PST) and genetic testing.
Screening
Genetic screening for psoriasis
- The strong involvement of genetics in the development of psoriasis allows for screening for this disease via genetic testing.
- HLA Class I antigens (HLA-B13, HLA-B57, HLA-B39, HLA-Cw6, HLACw7) have been shown to be associated with psoriasis and psoriatic arthritis.[1]
- HLA-B13, -B16, and its splits -B38 and -B39, B17, and Cw6 are associated with psoriasis, with or without arthritis.
- Early screening combined with early treatment can help prevent disease progression.
- A sample for genetic testing is usually taken from a cheek swab.
Psoriasis screening tool (PST)
- The Psoriasis Screening Tool (PST) consists of eight questions with a "yes" or "no" response with typical images of skin, nail, and scalp changes in psoriasis included with respective questions.[2]
- The questions distinguish individuals with psoriasis from individuals without the disease in an outpatient setting.
- A similar questionnaire exists for psoriatic arthritis, called the Psoriasis Epidemiology Screening Tool (PEST).[3]
References
- ↑ Gladman DD, Farewell VT (2003). "HLA studies in psoriatic arthritis: current situation and future needs". J. Rheumatol. 30 (1): 4–6. PMID 12508382.
- ↑ Dominguez PL, Assarpour A, Kuo H, Holt EW, Tyler S, Qureshi AA (2009). "Development and pilot-testing of a psoriasis screening tool". Br. J. Dermatol. 161 (4): 778–84. doi:10.1111/j.1365-2133.2009.09247.x. PMID 19566664.
- ↑ "Psoriasis Epidemiology Screening Tool (PEST): A Report from the GRAPPA 2009 Annual Meeting | The Journal of Rheumatology".