Thyroid nodule differential diagnosis: Difference between revisions
No edit summary |
|||
| Line 115: | Line 115: | ||
* PAX8-PPAR gamma 1 | * PAX8-PPAR gamma 1 | ||
| | | | ||
|- | |- | ||
| | | | ||
| Line 196: | Line 194: | ||
|Malignant | |Malignant | ||
|Papillary carcinoma | |Papillary carcinoma | ||
| | |<nowiki>+++</nowiki> | ||
| | |<nowiki>+</nowiki> | ||
| | | | ||
|↑↑↑ | |↑↑↑ | ||
| Line 207: | Line 205: | ||
| | | | ||
| | | | ||
|multifocal | |||
|unencapsulated and may be partially cystic | |||
|papillae consisting of one or two layers of tumor cells surrounding a well-defined fibrovascular core; follicles and colloid are typically absent | |||
The nuclei are large, oval, and appear crowded and overlapping on microscopic sections. They may contain hypodense powdery chromatin, cytoplasmic pseudoinclusions due to a redundant nuclear membrane, or nuclear grooves. | |||
| | | | ||
* ''RET''/PTC | |||
* ''NTRK1'' | |||
* ''RAS'' | |||
* ''BRAF'' | |||
| | | | ||
|- | |- | ||
| | | | ||
| Line 228: | Line 231: | ||
| | | | ||
| | | | ||
| | |Unifolcal | ||
|FLUS | |FLUS | ||
| | | | ||
| Line 236: | Line 239: | ||
* ''RAS'' mutations | * ''RAS'' mutations | ||
* PAX8-PPAR gamma 1 | * PAX8-PPAR gamma 1 | ||
| | |Most common thyroid cancer in iodine deficient areas | ||
|- | |- | ||
| | | | ||
Revision as of 19:23, 9 August 2017
|
Thyroid nodule Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Thyroid nodule differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Thyroid nodule differential diagnosis |
|
Risk calculators and risk factors for Thyroid nodule differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
Thyroid nodule differential diagnosis
In rare cases, a thyroid nodule may reflect one of the hereditary nonmedullary thyroid cancer syndromes such as familial adenomatous polyposis, Werner’s syndrome, Carney complex type 1, or Gardner’s syndrome
| Nodule property | Spread | Sudden growth
of neck mass |
Laboratory | Thyroid scintigraphy | Biopsy result
if indicated |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fixed | Mobile | Painful | LN | Vessle | Metastasis | TSH | FT4/T3 | Hot | Cold | US finding | FNA finding | Associated mutation | special consideration | ||||
| Benign | Colloid adenoma | ||||||||||||||||
| Hashimoto's thyroiditis | |||||||||||||||||
| Cysts nodules | |||||||||||||||||
| Follicular adenomas | ↑↑↑ |
|
|||||||||||||||
| Hyperplastic nodules | ↑↑↑ | ||||||||||||||||
| Macrofollicular adenomas | ↑↑ | ||||||||||||||||
| Microfollicular or cellular adenomas | ↑↑ | ||||||||||||||||
| Hürthle cell adenomas | ↑↓ | ||||||||||||||||
| Malignant | Papillary carcinoma | +++ | + | ↑↑↑ | multifocal | unencapsulated and may be partially cystic | papillae consisting of one or two layers of tumor cells surrounding a well-defined fibrovascular core; follicles and colloid are typically absent
The nuclei are large, oval, and appear crowded and overlapping on microscopic sections. They may contain hypodense powdery chromatin, cytoplasmic pseudoinclusions due to a redundant nuclear membrane, or nuclear grooves. |
|
|||||||||
| Follicular carcinoma | ↑↑↑ | Bone
Lung |
↑↓ | Unifolcal | FLUS |
|
|
Most common thyroid cancer in iodine deficient areas | |||||||||
| Oxyphilic (Hürthle cell) type carcinoma | |||||||||||||||||
| Noninvasive follicular thyroid neoplasm
with papillary-like nuclear features |
|||||||||||||||||
| Medullary carcinoma | |||||||||||||||||
| Anaplastic carcinoma | ↑ | ||||||||||||||||
| Primary thyroid lymphoma | |||||||||||||||||
| Metastatic carcinoma | |||||||||||||||||