Riedel's thyroiditis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
The exact pathogenesis of Riedel's thyroiditis is not fully understood. It is thought that Riedel's thyroiditis is the result of | |||
Riedel's thyroiditis is characterized by a replacement of the normal thyroid parenchyma by a dense [[fibrosis]] that invades adjacent structures of the neck and extends beyond the thyroid capsule.<ref name="pmid17603227">{{cite journal |author=Cho MH, Kim CS, Park JS, ''et al'' |title=Riedel's thyroiditis in a patient with recurrent subacute thyroiditis: a case report and review of the literature |journal=Endocr. J. |volume=54 |issue=4 |pages=559–62 |year=2007 |month=August |pmid=17603227 |doi= |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/endocrj/K06-186?from=PubMed}}</ref> This makes the thyroid gland stone-hard and fixed to adjacent structures. | Riedel's thyroiditis is characterized by a replacement of the normal thyroid parenchyma by a dense [[fibrosis]] that invades adjacent structures of the neck and extends beyond the thyroid capsule.<ref name="pmid17603227">{{cite journal |author=Cho MH, Kim CS, Park JS, ''et al'' |title=Riedel's thyroiditis in a patient with recurrent subacute thyroiditis: a case report and review of the literature |journal=Endocr. J. |volume=54 |issue=4 |pages=559–62 |year=2007 |month=August |pmid=17603227 |doi= |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/endocrj/K06-186?from=PubMed}}</ref> This makes the thyroid gland stone-hard and fixed to adjacent structures. | ||
A shared mechanism with [[retroperitoneal fibrosis]] and [[sclerosing cholangitis]] has been suggested.<ref name="pmid8504980">{{cite journal |author=De Boer WA |title=Riedel's thyroiditis, retroperitoneal fibrosis, and sclerosing cholangitis: diseases with one pathogenesis? |journal=Gut |volume=34 |issue=5 |pages=714 |year=1993 |month=May |pmid=8504980 |pmc=1374200 |doi= |url=http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=8504980}}</ref> | A shared mechanism with [[retroperitoneal fibrosis]] and [[sclerosing cholangitis]] has been suggested.<ref name="pmid8504980">{{cite journal |author=De Boer WA |title=Riedel's thyroiditis, retroperitoneal fibrosis, and sclerosing cholangitis: diseases with one pathogenesis? |journal=Gut |volume=34 |issue=5 |pages=714 |year=1993 |month=May |pmid=8504980 |pmc=1374200 |doi= |url=http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=8504980}}</ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 16:34, 10 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The exact pathogenesis of Riedel's thyroiditis is not fully understood. It is thought that Riedel's thyroiditis is the result of Riedel's thyroiditis is characterized by a replacement of the normal thyroid parenchyma by a dense fibrosis that invades adjacent structures of the neck and extends beyond the thyroid capsule.[1] This makes the thyroid gland stone-hard and fixed to adjacent structures. A shared mechanism with retroperitoneal fibrosis and sclerosing cholangitis has been suggested.[2]
Pathophysiology
Pathogenesis
- The exact pathogenesis of [disease name] is not fully understood.
OR
- It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Cho MH, Kim CS, Park JS; et al. (2007). "Riedel's thyroiditis in a patient with recurrent subacute thyroiditis: a case report and review of the literature". Endocr. J. 54 (4): 559–62. PMID 17603227. Unknown parameter
|month=
ignored (help) - ↑ De Boer WA (1993). "Riedel's thyroiditis, retroperitoneal fibrosis, and sclerosing cholangitis: diseases with one pathogenesis?". Gut. 34 (5): 714. PMC 1374200. PMID 8504980. Unknown parameter
|month=
ignored (help)