Hashimoto's thyroiditis causes: Difference between revisions
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==Causes== | ==Causes== | ||
[[Hashimoto's thyroiditis|Hashimoto's thyroidit]]<nowiki/>is caused by:<ref name="pmid26361257">{{cite journal |vauthors=Ajjan RA, Weetman AP |title=The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding |journal=Horm. Metab. Res. |volume=47 |issue=10 |pages=702–10 |year=2015 |pmid=26361257 |doi=10.1055/s-0035-1548832 |url=}}</ref> | [[Hashimoto's thyroiditis|Hashimoto's thyroidit]]<nowiki/>is usually caused by:<ref name="pmid26361257">{{cite journal |vauthors=Ajjan RA, Weetman AP |title=The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding |journal=Horm. Metab. Res. |volume=47 |issue=10 |pages=702–10 |year=2015 |pmid=26361257 |doi=10.1055/s-0035-1548832 |url=}}</ref> | ||
===Common causes=== | ===Common causes=== | ||
*[[Thyroid peroxidase|Autoantibodies against Thyroid peroxidase]] and [[thyroglobulin]]. | *[[Thyroid peroxidase|Autoantibodies against Thyroid peroxidase]] and [[thyroglobulin]]. | ||
Revision as of 18:23, 10 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Hashimoto's thyroiditis may be caused by T cells and B cells auto activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.
Causes
Hashimoto's thyroiditis usually caused by:[1]
Common causes
- Autoantibodies against Thyroid peroxidase and thyroglobulin.
- Abnormalities in the suppressor T cells and regulatory T cells.
- HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement.
Less common cause
- Immunomodulatory drugs (e.g, interferon-alpha.)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Micro RNA involvement
- Polyglandular Syndrome
For the factors involved in the development of Hashimoto's thyroiditis, please click here.
References
- ↑ Ajjan RA, Weetman AP (2015). "The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding". Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.