Acromegaly differential diagnosis: Difference between revisions
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==Differentiating acromegaly from other Diseases== | ==Differentiating acromegaly from other Diseases== | ||
*Acromegaly must be differentiated from other diseases that cause acral features like skin thickening and linear bone growth. These diseases such as Marfan syndrome, precocious puberty, prolactinoma, hyperinsulinism, and pachydermoperiostosis.<ref name="pmid28567291">{{cite journal| author=Abdullah NRA, Jason WLC, Nasruddin AB| title=Pachydermoperiostosis: a rare mimicker of acromegaly. | journal=Endocrinol Diabetes Metab Case Rep | year= 2017 | volume= 2017 | issue= | pages= | pmid=28567291 | doi=10.1530/EDM-17-0029 | pmc=5445428 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28567291 }}</ref><ref name="pmid20591885">{{cite journal| author=Loeys BL, Dietz HC, Braverman AC, Callewaert BL, De Backer J, Devereux RB et al.| title=The revised Ghent nosology for the Marfan syndrome. | journal=J Med Genet | year= 2010 | volume= 47 | issue= 7 | pages= 476-85 | pmid=20591885 | doi=10.1136/jmg.2009.072785 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20591885 }}</ref><ref name="pmid15191331">{{cite journal| author=Liu JK, Couldwell WT| title=Contemporary management of prolactinomas. | journal=Neurosurg Focus | year= 2004 | volume= 16 | issue= 4 | pages= E2 | pmid=15191331 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15191331 }}</ref> | *Acromegaly must be differentiated from other diseases that cause acral features like skin thickening and linear bone growth. These diseases such as Marfan syndrome, precocious puberty, prolactinoma, hyperinsulinism, and pachydermoperiostosis.<ref name="pmid28567291">{{cite journal| author=Abdullah NRA, Jason WLC, Nasruddin AB| title=Pachydermoperiostosis: a rare mimicker of acromegaly. | journal=Endocrinol Diabetes Metab Case Rep | year= 2017 | volume= 2017 | issue= | pages= | pmid=28567291 | doi=10.1530/EDM-17-0029 | pmc=5445428 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28567291 }}</ref><ref name="pmid20591885">{{cite journal| author=Loeys BL, Dietz HC, Braverman AC, Callewaert BL, De Backer J, Devereux RB et al.| title=The revised Ghent nosology for the Marfan syndrome. | journal=J Med Genet | year= 2010 | volume= 47 | issue= 7 | pages= 476-85 | pmid=20591885 | doi=10.1136/jmg.2009.072785 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20591885 }}</ref><ref name="pmid15191331">{{cite journal| author=Liu JK, Couldwell WT| title=Contemporary management of prolactinomas. | journal=Neurosurg Focus | year= 2004 | volume= 16 | issue= 4 | pages= E2 | pmid=15191331 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15191331 }}</ref><ref name="pmid16860125">{{cite journal| author=Papadimitriou A, Beri D, Tsialla A, Fretzayas A, Psychou F, Nicolaidou P| title=Early growth acceleration in girls with idiopathic precocious puberty. | journal=J Pediatr | year= 2006 | volume= 149 | issue= 1 | pages= 43-6 | pmid=16860125 | doi=10.1016/j.jpeds.2006.02.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16860125 }}</ref> | ||
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* On physical examination, Marfan syndrome patients have small jaws that distinguish it from acromegaly. | * On physical examination, Marfan syndrome patients have small jaws that distinguish it from acromegaly. | ||
* Patients with Marfan syndrome have arachnodactyly with positive thumb and wrist signs. | * Patients with Marfan syndrome have arachnodactyly with positive thumb and wrist signs. | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Precocious puberty | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
* On | * On physical examination, excess linear bone growth is noticed like the acromegaly. | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
* On | * On laboratory diagnosis, precocious puberty has demonstrated high levels of FSH, LH and testosterone that distinguish it from acromegaly. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Pachydermoperiostosis | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Pachydermoperiostosis | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
* On [physical exam; history; diagnostic test; imaging], [Differential 1] {has; demonstrates} [feature 1], [feature 2], [feature 3] also observed in [disease name]. | * On [physical exam; history; diagnostic test; imaging], [Differential 1] {has; demonstrates} [feature 1], [feature 2], [feature 3] also observed in [disease name]. | ||
Revision as of 21:56, 13 August 2017
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Overview
Acromegaly must be differentiated from other diseases that cause acral features like skin thickening and linear bone growth. These diseases such as Marfan syndrome, McCune Albright syndrome, hyperinsulinism, pachydermoperiostosis and fragile X syndrome.
Differentiating acromegaly from other Diseases
- Acromegaly must be differentiated from other diseases that cause acral features like skin thickening and linear bone growth. These diseases such as Marfan syndrome, precocious puberty, prolactinoma, hyperinsulinism, and pachydermoperiostosis.[1][2][3][4]
| Differential Diagnosis | Similar Features | Differentiating Features |
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| Prolactinoma |
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| Marfan syndrome |
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| Precocious puberty |
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| Pachydermoperiostosis |
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References
- ↑ Abdullah NRA, Jason WLC, Nasruddin AB (2017). "Pachydermoperiostosis: a rare mimicker of acromegaly". Endocrinol Diabetes Metab Case Rep. 2017. doi:10.1530/EDM-17-0029. PMC 5445428. PMID 28567291.
- ↑ Loeys BL, Dietz HC, Braverman AC, Callewaert BL, De Backer J, Devereux RB; et al. (2010). "The revised Ghent nosology for the Marfan syndrome". J Med Genet. 47 (7): 476–85. doi:10.1136/jmg.2009.072785. PMID 20591885.
- ↑ Liu JK, Couldwell WT (2004). "Contemporary management of prolactinomas". Neurosurg Focus. 16 (4): E2. PMID 15191331.
- ↑ Papadimitriou A, Beri D, Tsialla A, Fretzayas A, Psychou F, Nicolaidou P (2006). "Early growth acceleration in girls with idiopathic precocious puberty". J Pediatr. 149 (1): 43–6. doi:10.1016/j.jpeds.2006.02.005. PMID 16860125.