Gynecomastia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* | * Asmptomatic gynecomastia which is discovered on physical examination and have no underlying known pathology has low diagnostic yield of labs. | ||
* Gynecomastia which is tender and of recent onset should have, following lab work up:<ref name="pmid17881754">{{cite journal| author=Braunstein GD| title=Clinical practice. Gynecomastia. | journal=N Engl J Med | year= 2007 | volume= 357 | issue= 12 | pages= 1229-37 | pmid=17881754 | doi=10.1056/NEJMcp070677 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17881754 }} </ref><ref name="pmid17090633">{{cite journal| author=Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H| title=Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. | journal=J Clin Endocrinol Metab | year= 2007 | volume= 92 | issue= 2 | pages= 405-13 | pmid=17090633 | doi=10.1210/jc.2006-1864 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17090633 }} </ref><ref name="pmid11158037">{{cite journal| author=Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Baltimore Longitudinal Study of Aging| title=Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. | journal=J Clin Endocrinol Metab | year= 2001 | volume= 86 | issue= 2 | pages= 724-31 | pmid=11158037 | doi=10.1210/jcem.86.2.7219 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11158037 }} </ref><ref name="pmid3532913">{{cite journal| author=Ismail AA, Astley P, Burr WA, Cawood M, Short F, Wakelin K et al.| title=The role of testosterone measurement in the investigation of androgen disorders. | journal=Ann Clin Biochem | year= 1986 | volume= 23 ( Pt 2) | issue= | pages= 113-34 | pmid=3532913 | doi=10.1177/000456328602300201 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3532913 }} </ref> | * Gynecomastia which is tender and of recent onset should have, following lab work up:<ref name="pmid17881754">{{cite journal| author=Braunstein GD| title=Clinical practice. Gynecomastia. | journal=N Engl J Med | year= 2007 | volume= 357 | issue= 12 | pages= 1229-37 | pmid=17881754 | doi=10.1056/NEJMcp070677 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17881754 }} </ref><ref name="pmid17090633">{{cite journal| author=Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H| title=Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. | journal=J Clin Endocrinol Metab | year= 2007 | volume= 92 | issue= 2 | pages= 405-13 | pmid=17090633 | doi=10.1210/jc.2006-1864 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17090633 }} </ref><ref name="pmid11158037">{{cite journal| author=Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Baltimore Longitudinal Study of Aging| title=Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. | journal=J Clin Endocrinol Metab | year= 2001 | volume= 86 | issue= 2 | pages= 724-31 | pmid=11158037 | doi=10.1210/jcem.86.2.7219 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11158037 }} </ref><ref name="pmid3532913">{{cite journal| author=Ismail AA, Astley P, Burr WA, Cawood M, Short F, Wakelin K et al.| title=The role of testosterone measurement in the investigation of androgen disorders. | journal=Ann Clin Biochem | year= 1986 | volume= 23 ( Pt 2) | issue= | pages= 113-34 | pmid=3532913 | doi=10.1177/000456328602300201 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3532913 }} </ref> | ||
** [[Alpha-fetoprotein]] ([[AFP]] | ** [[Alpha-fetoprotein]] ([[AFP]] | ||
** [[Blood urea nitrogen]] ([[BUN]]) | ** [[Blood urea nitrogen]] ([[BUN]]) | ||
** [[Creatinine]] ([[Cr]]) | ** [[Creatinine]] ([[Cr]]) | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Gynecomastia which is recent in onset and tender on the examination should have serum concentrations of human chorionic gonadotropin (hCG), LH, testosterone, and estradiol measured.
Laboratory Findings
- Asmptomatic gynecomastia which is discovered on physical examination and have no underlying known pathology has low diagnostic yield of labs.
- Gynecomastia which is tender and of recent onset should have, following lab work up:[1][2][3][4]
References
- ↑ Braunstein GD (2007). "Clinical practice. Gynecomastia". N Engl J Med. 357 (12): 1229–37. doi:10.1056/NEJMcp070677. PMID 17881754.
- ↑ Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H (2007). "Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement". J Clin Endocrinol Metab. 92 (2): 405–13. doi:10.1210/jc.2006-1864. PMID 17090633.
- ↑ Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Baltimore Longitudinal Study of Aging (2001). "Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging". J Clin Endocrinol Metab. 86 (2): 724–31. doi:10.1210/jcem.86.2.7219. PMID 11158037.
- ↑ Ismail AA, Astley P, Burr WA, Cawood M, Short F, Wakelin K; et al. (1986). "The role of testosterone measurement in the investigation of androgen disorders". Ann Clin Biochem. 23 ( Pt 2): 113–34. doi:10.1177/000456328602300201. PMID 3532913.