De Quervain's thyroiditis other diagnostic studies: Difference between revisions
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{{CMG}}; {{AE}} {{MMF}} | {{CMG}}; {{AE}} {{MMF}} | ||
==Overview== | ==Overview== | ||
The histological analysis in de Quervain's thyroiditis may show the destruction of the follicular epithelium, loss of the follicular integrity and infiltration of [[inflammatory cells]]. [[FNA|Fine needle aspiration cytology]] helps to differentiate between the [[Thyroid nodule|benign]] and [[Thyroid nodule|malignant nodules]]. | The histological analysis in de Quervain's thyroiditis may show the destruction of the follicular epithelium, loss of the follicular integrity, and infiltration of [[inflammatory cells]]. [[FNA|Fine needle aspiration cytology]] helps to differentiate between the [[Thyroid nodule|benign]] and [[Thyroid nodule|malignant nodules]]. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Fine needle aspiration cytology=== | ===Fine needle aspiration cytology=== | ||
[[Needle aspiration biopsy|Fine needle aspiration]] is usually done under ultrasound guidance and the sample is sent for [[cytology]]. It helps to differentiate benign thyroid nodules from the malignant lesions.<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid12727961">{{cite journal |vauthors=Fatourechi V, Aniszewski JP, Fatourechi GZ, Atkinson EJ, Jacobsen SJ |title=Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue=5 |pages=2100–5 |year=2003 |pmid=12727961 |doi=10.1210/jc.2002-021799 |url=}}</ref> | [[Needle aspiration biopsy|Fine needle aspiration]] is usually done under [[ultrasound]] guidance and the sample is sent for [[cytology]]. It helps to differentiate [[Thyroid nodule|benign thyroid nodules]] from the malignant lesions.<ref name="urlThyroiditis — NEJM">{{cite web |url=http://www.nejm.org/doi/full/10.1056/NEJMra021194 |title=Thyroiditis — NEJM |format= |work= |accessdate=}}</ref><ref name="pmid12727961">{{cite journal |vauthors=Fatourechi V, Aniszewski JP, Fatourechi GZ, Atkinson EJ, Jacobsen SJ |title=Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue=5 |pages=2100–5 |year=2003 |pmid=12727961 |doi=10.1210/jc.2002-021799 |url=}}</ref> | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Microscopic findings suggesting [[de Quervain's thyroiditis]] are as followings:<ref name="pmid12608662">{{cite journal |vauthors=Kojima M, Nakamura S, Oyama T, Sugihara S, Sakata N, Masawa N |title=Cellular composition of subacute thyroiditis. an immunohistochemical study of six cases |journal=Pathol. Res. Pract. |volume=198 |issue=12 |pages=833–7 |year=2002 |pmid=12608662 |doi=10.1078/0344-0338-00344 |url=}}</ref> | |||
*[[Granuloma]] comprises of [[colloid]], small [[Lymphocyte|lymphocytes]], [[neutrophil]]<nowiki/>s, and [[Macrophage|macrophages]] with or without epithelioid features | *[[Granuloma]] comprises of [[colloid]], small [[Lymphocyte|lymphocytes]], [[neutrophil]]<nowiki/>s, and [[Macrophage|macrophages]] with or without epithelioid features | ||
*Destruction of the follicular epithelium | *Destruction of the follicular epithelium | ||
*Loss of the follicular integrity | *Loss of the follicular integrity | ||
*Patchy distribution of [[Granulomas|non-caseous granulomas]] | *Patchy distribution of [[Granulomas|non-caseous granulomas]] | ||
==Gallery== | ==Gallery== | ||
Revision as of 19:29, 18 August 2017
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De Quervain's thyroiditis Microchapters |
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Differentiating De Quervain's thyroiditis from other Diseases |
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Diagnosis |
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Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
The histological analysis in de Quervain's thyroiditis may show the destruction of the follicular epithelium, loss of the follicular integrity, and infiltration of inflammatory cells. Fine needle aspiration cytology helps to differentiate between the benign and malignant nodules.
Other Diagnostic Studies
Fine needle aspiration cytology
Fine needle aspiration is usually done under ultrasound guidance and the sample is sent for cytology. It helps to differentiate benign thyroid nodules from the malignant lesions.[1][2]
Microscopic Pathology
Microscopic findings suggesting de Quervain's thyroiditis are as followings:[3]
- Granuloma comprises of colloid, small lymphocytes, neutrophils, and macrophages with or without epithelioid features
- Destruction of the follicular epithelium
- Loss of the follicular integrity
- Patchy distribution of non-caseous granulomas
Gallery
-
De Quervain's thyroiditis (By Nephron - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=18491382) -
De Quervain's thyroiditis (By Nephron - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=18491421) -
De Quervain's thyroiditis (By Nephron - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=18491421) -
![De Quervain's thyroiditis; Inflammatory rich smear with giant cells and probable granulomata. (Case courtesy of Dr Andrew Ryan, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/17052">rID: 17052</a>)]]](/images/1/1c/Subacute-de-quervains-thyroiditis_%283%29.jpg)
De Quervain's thyroiditis; Inflammatory rich smear with giant cells and probable granulomata. (Case courtesy of Dr Andrew Ryan, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/17052">rID: 17052</a>)]] -
De Quervain's thyroiditis; Cluster of epithelioid histiocytes with associated inflammatory cells and debris and group of benign follicular epithelial cells. (Case courtesy of Dr Andrew Ryan, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/17052">rID: 17052</a>)
![De Quervain's thyroiditis; Inflammatory rich smear with giant cells and probable granulomata. (Case courtesy of Dr Andrew Ryan, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/17052">rID: 17052</a>)]]](/index.php/File:Subacute-de-quervains-thyroiditis_(3).jpg)
.jpg)
References
- ↑ "Thyroiditis — NEJM".
- ↑ Fatourechi V, Aniszewski JP, Fatourechi GZ, Atkinson EJ, Jacobsen SJ (2003). "Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study". J. Clin. Endocrinol. Metab. 88 (5): 2100–5. doi:10.1210/jc.2002-021799. PMID 12727961.
- ↑ Kojima M, Nakamura S, Oyama T, Sugihara S, Sakata N, Masawa N (2002). "Cellular composition of subacute thyroiditis. an immunohistochemical study of six cases". Pathol. Res. Pract. 198 (12): 833–7. doi:10.1078/0344-0338-00344. PMID 12608662.