Struma ovarii pathophysiology: Difference between revisions
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*Thyrotoxicosis <ref name="pmid17276434">{{cite journal |vauthors=Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P |title=Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism |journal=Fertil. Steril. |volume=88 |issue=2 |pages=497.e15–7 |year=2007 |pmid=17276434 |pmc=2753978 |doi=10.1016/j.fertnstert.2006.11.095 |url=}}</ref> | *Thyrotoxicosis <ref name="pmid17276434">{{cite journal |vauthors=Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P |title=Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism |journal=Fertil. Steril. |volume=88 |issue=2 |pages=497.e15–7 |year=2007 |pmid=17276434 |pmc=2753978 |doi=10.1016/j.fertnstert.2006.11.095 |url=}}</ref> | ||
*Peritoneal strumosis which are benign lesions may also occur. <ref name="ButtWantenaar2016">{{cite journal|last1=Butt|first1=Jennifer L|last2=Wantenaar|first2=Tanya I|title=The diagnosis and management of struma ovarii|journal=Southern African Journal of Gynaecological Oncology|volume=8|issue=1|year=2016|pages=24–26|issn=2074-2835|doi=10.1080/20742835.2016.1180776}}</ref> | *Peritoneal strumosis which are benign lesions may also occur. <ref name="ButtWantenaar2016">{{cite journal|last1=Butt|first1=Jennifer L|last2=Wantenaar|first2=Tanya I|title=The diagnosis and management of struma ovarii|journal=Southern African Journal of Gynaecological Oncology|volume=8|issue=1|year=2016|pages=24–26|issn=2074-2835|doi=10.1080/20742835.2016.1180776}}</ref> | ||
*Struma ovarii can be seen associated with: <ref name="pmid24357453">{{cite journal |vauthors=Dujardin MI, Sekhri P, Turnbull LW |title=Struma ovarii: role of imaging? |journal=Insights Imaging |volume=5 |issue=1 |pages=41–51 |year=2014 |pmid=24357453 |pmc=3948908 |doi=10.1007/s13244-013-0303-3 |url=}}</ref> | |||
:*Serous cystadenoma | |||
:*Mucinous cystadenoma | |||
:*Brenner's tumor | |||
:*Carcinoid tumor | |||
==Gross Pathology== | ==Gross Pathology== | ||
Revision as of 02:35, 21 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
It is thought that Struma ovarii is mediated by activation of the mitogen activated protein kinase signaling pathway as a critical step in tumorigenesis. Malignant struma ovarii (MSO) are rare tumors which arise from ectopic thyroid tissue in the ovary which is benign.
Pathophysiology
Pathogenesis
- It is thought that Struma ovarii is mediated by activation of the mitogen activated protein kinase signaling pathway as a critical step in tumorigenesis. This process has been understood by molecular analysis of follicular cell derived thyroid carcinomas. [1]
- Malignant transformation of Struma ovarii is reported to occur in less than 5% of all cases, and it is even less likely to lead to metastatic disease (5–6%). [2] [3]
- In Malignant Struma ovarii (MSO), the cancer can spread to the contralateral ovary, abdominopelvic lymph nodes, the omentum, the peritoneal cavity, lungs, scalp, bone, brain, pleura, diaphragm, and liver. [4]
- Metastasis is rare and about 5% in with malignant struma ovarii (MSO). Routes of metastasis are: [5] [6] [7]
- 1) Regional lymphatics to pelvic and paraaortic lymph nodes
- 2) Direct spread to the omentum and peritoneal cavity, the contralateral cavity
- 3) Hematologic dissemination to the bone, lung, liver and brain
Genetics
- Malignant struma ovarii (MSO) are rare tumors which arise from ectopic thyroid tissue in the ovary which is benign.
- Malignant struma ovarii (MSO) are classified histologically as papillary thyroid carcinomas (PTC). The genes involved in the pathogenesis of Malignant struma ovarii (MSO) include BRAF (35% to 69%), RAS (10%), and RET (5% to 30%). [1]
- The development of Malignant struma ovarii (MSO) along with papillary thyroid carcinomas (PTC) features is associated with mutations in the BRAF of the type which is commonly observed in PTC, therefore it suggests a common pathogenesis for all PTCs regardless of their location. On the contrary, mutations in the RET/RAS/RAF pathway are not observed in BSO. [1]
Associated Conditions
- Adenomatous or colloid cervical goiters. [8]
- Hyperthyroidism in postmenopausal woman. [9]
- Pseudo-Meig's syndrome [10]
- Hashimoto's thyroiditis [11]
- Thyrotoxicosis [11]
- Peritoneal strumosis which are benign lesions may also occur. [12]
- Struma ovarii can be seen associated with: [13]
- Serous cystadenoma
- Mucinous cystadenoma
- Brenner's tumor
- Carcinoid tumor
Gross Pathology
- Solid and cystic tumor.
- Tumor with several nodules partially separated by gray whitish fibrous tissue.
- Nodules appear tan-brown in color with small dark red areas.
- Cystic spaces filled with yellow-brown or straw-colored fluid.
- Focal areas of calcification are observed.
Microscopic Pathology
- On microscopic histopathological analysis the tumor was initially diagnosed as granulosa cell tumor in frozen study but finally turned out to be Struma Ovarii which is the characteristic finding of Struma ovarii. [10]
- Hematoxylin and eosin-stained tissue helps analyze branching papillae with atypical cytologic features including nuclear groves, clearing, overlapping, and enlargement, consistent with papillary thyroid carcinoma arising in a struma ovarii. [16]
References
- ↑ 1.0 1.1 1.2 Schmidt J, Derr V, Heinrich MC, Crum CP, Fletcher JA, Corless CL, Nosé V (2007). "BRAF in papillary thyroid carcinoma of ovary (struma ovarii)". Am. J. Surg. Pathol. 31 (9): 1337–43. doi:10.1097/PAS.0b013e31802f5404. PMID 17721188.
- ↑ Dardik RB, Dardik M, Westra W, Montz FJ (1999). "Malignant struma ovarii: two case reports and a review of the literature". Gynecol. Oncol. 73 (3): 447–51. doi:10.1006/gyno.1999.5355. PMID 10366477.
- ↑ Oudoux A, Leblanc E, Beaujot J, Gauthier-Kolesnikov H (2016). "Treatment and follow-up of malignant struma ovarii: Regarding two cases". Gynecol Oncol Rep. 17: 56–9. doi:10.1016/j.gore.2016.05.014. PMC 4913172. PMID 27355004.
- ↑ Luo JR, Xie CB, Li ZH (2014). "Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature". Medicine (Baltimore). 93 (26): e147. doi:10.1097/MD.0000000000000147. PMC 4616397. PMID 25474425.
- ↑ Yücesoy G, Cakiroglu Y, Muezzinoglu B, Besnili B, Yucesoy I (2010). "Malignant struma ovarii: a case report". J. Korean Med. Sci. 25 (2): 327–9. doi:10.3346/jkms.2010.25.2.327. PMC 2811308. PMID 20119594.
- ↑ Rosenblum NG, LiVolsi VA, Edmonds PR, Mikuta JJ (1989). "Malignant struma ovarii". Gynecol. Oncol. 32 (2): 224–7. PMID 2910784.
- ↑ Chan SW, Farrell KE (2001). "Metastatic thyroid carcinoma in the presence of struma ovarii". Med. J. Aust. 175 (7): 373–4. PMID 11700816.
- ↑ Kempers RD, Dockerty MB, Hoffman DL, Bartholomew LG (1970). "Struma ovarii--ascitic, hyperthyroid, and asymptomatic syndromes". Ann. Intern. Med. 72 (6): 883–93. PMID 5448747.
- ↑ Nonne N, Ameyar-Zazoua M, Souidi M, Harel-Bellan A (2010). "Tandem affinity purification of miRNA target mRNAs (TAP-Tar)". Nucleic Acids Res. 38 (4): e20. doi:10.1093/nar/gkp1100. PMC 2831319. PMID 19955234.
- ↑ 10.0 10.1 10.2 Mostaghel N, Enzevaei A, Zare K, Fallahian M (2012). "Struma ovarii associated with Pseudo-Meig's syndrome and high serum level of CA 125; a case report". J Ovarian Res. 5: 10. doi:10.1186/1757-2215-5-10. PMC 3350392. PMID 22436494.
- ↑ 11.0 11.1 Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P (2007). "Struma ovarii coincident with Hashimoto's thyroiditis: an unusual cause of hyperthyroidism". Fertil. Steril. 88 (2): 497.e15–7. doi:10.1016/j.fertnstert.2006.11.095. PMC 2753978. PMID 17276434.
- ↑ Butt, Jennifer L; Wantenaar, Tanya I (2016). "The diagnosis and management of struma ovarii". Southern African Journal of Gynaecological Oncology. 8 (1): 24–26. doi:10.1080/20742835.2016.1180776. ISSN 2074-2835.
- ↑ Dujardin MI, Sekhri P, Turnbull LW (2014). "Struma ovarii: role of imaging?". Insights Imaging. 5 (1): 41–51. doi:10.1007/s13244-013-0303-3. PMC 3948908. PMID 24357453.
- ↑ Piérard GE, Piérard-Franchimont C (1987). "[Acute and chronic borrelioses transmitted by ticks along the Meuse River and in bordering regions]". Rev Med Liege (in French). 42 (3): 101–6. PMID 3563194.
- ↑ Gaitan E, Cooksey RC, Meydrech EF, Legan J, Gaitan GS, Astudillo J, Guzman R, Guzman N, Medina P (1989). "Thyroid function in neonates from goitrous and nongoitrous iodine-sufficient areas". J. Clin. Endocrinol. Metab. 69 (2): 359–63. doi:10.1210/jcem-69-2-359. PMID 2753978.
- ↑ 16.0 16.1 Alvarez DM, Lee V, Bhatt S, Dogra VS (2011). "Struma ovarii with papillary thyroid carcinoma". J Clin Imaging Sci. 1: 44. doi:10.4103/2156-7514.84322. PMC 3272908. PMID 22315711.