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*Pituitry gland is amongst the most vascularized tissues in the body that normally weighs about 0.5g but gets doubled in size during pregnancy.<ref name="pmid8325288">{{cite journal |vauthors=Rolih CA, Ober KP |title=Pituitary apoplexy |journal=Endocrinol. Metab. Clin. North Am. |volume=22 |issue=2 |pages=291–302 |year=1993 |pmid=8325288 |doi= |url=}}</ref> Pituitary gland enlargement due to hypertrophy and hyperplasia of lactotrophic cells in anterior pituitary resulting in superior hypophyseal artery compression complicated by decreased portal pressure and vasospasm during delivery  play an important role in the pathogenesis of Sheehan syndrome.<ref name="pmid2159093">{{cite journal |vauthors=Scheithauer BW, Sano T, Kovacs KT, Young WF, Ryan N, Randall RV |title=The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases |journal=Mayo Clin. Proc. |volume=65 |issue=4 |pages=461–74 |year=1990 |pmid=2159093 |doi= |url=}}</ref>
*Pituitry gland is amongst the most vascularized tissues in the body that normally weighs about 0.5g but gets doubled in size during pregnancy.<ref name="pmid8325288">{{cite journal |vauthors=Rolih CA, Ober KP |title=Pituitary apoplexy |journal=Endocrinol. Metab. Clin. North Am. |volume=22 |issue=2 |pages=291–302 |year=1993 |pmid=8325288 |doi= |url=}}</ref> Pituitary gland enlargement due to hypertrophy and hyperplasia of lactotrophic cells in anterior pituitary resulting in superior hypophyseal artery compression complicated by decreased portal pressure and vasospasm during delivery  play an important role in the pathogenesis of Sheehan syndrome.<ref name="pmid2159093">{{cite journal |vauthors=Scheithauer BW, Sano T, Kovacs KT, Young WF, Ryan N, Randall RV |title=The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases |journal=Mayo Clin. Proc. |volume=65 |issue=4 |pages=461–74 |year=1990 |pmid=2159093 |doi= |url=}}</ref>
*Apart from pituitary gland enlargement during and before parturition, vasospasm, generalized Schwartzman phenomenon,thrombosis and compression of the hypophyseal arteries, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref><ref>{{cite journal |last=Apitz |first=Kurt |date=September 1, 1935 |title=A Study of the Generalized Shwartzman Phenomenon|url=http://www.jimmunol.org/content/29/3/255.short|journal=The Journal of Immunology |volume=29 |issue=3 |pages=255-266}}</ref><ref name="McKayMerrill1953">{{cite journal|last1=McKay|first1=Donald G.|last2=Merrill|first2=Samuel J.|last3=Weiner|first3=Albert E.|last4=Hertig|first4=Arthur T.|last5=Reid|first5=Duncan E.|title=The pathologic anatomy of eclampsia, bilateral renal cortical necrosis, pituitary necrosis, and other acute fatal complications of pregnancy, and its possible relationship to the generalized Shwartzman phenomenon|journal=American Journal of Obstetrics and Gynecology|volume=66|issue=3|year=1953|pages=507–539|issn=00029378|doi=10.1016/0002-9378(53)90068-4}}</ref> It is thought that tissue necrosis results in release of sequestered antigens, precipitating autoimmunity of the pituitary gland and hypopituitarism in Sheehan's syndrome.<ref name="pmid12213861">{{cite journal |vauthors=Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N |title=Pituitary autoimmunity in patients with Sheehan's syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue=9 |pages=4137–41 |year=2002 |pmid=12213861 |doi=10.1210/jc.2001-020242 |url=}}</ref> Type 1 diabetes, pre-existinfg vascular diseases and any pituitary masses are associated with increased risk of developing Sheehan syndrome in pregnancy <ref name="Abourawi2006">{{cite journal|last1=Abourawi|first1=F|title=Diabetes Mellitus and Pregnancy|journal=Libyan Journal of Medicine|volume=1|issue=1|year=2006|pages=28–41|issn=19932820|doi=10.4176/060617}}</ref>
*Apart from pituitary gland enlargement during and before parturition, vasospasm, generalized Schwartzman phenomenon,thrombosis and compression of the hypophyseal arteries, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref><ref>{{cite journal |last=Apitz |first=Kurt |date=September 1, 1935 |title=A Study of the Generalized Shwartzman Phenomenon|url=http://www.jimmunol.org/content/29/3/255.short|journal=The Journal of Immunology |volume=29 |issue=3 |pages=255-266}}</ref><ref name="McKayMerrill1953">{{cite journal|last1=McKay|first1=Donald G.|last2=Merrill|first2=Samuel J.|last3=Weiner|first3=Albert E.|last4=Hertig|first4=Arthur T.|last5=Reid|first5=Duncan E.|title=The pathologic anatomy of eclampsia, bilateral renal cortical necrosis, pituitary necrosis, and other acute fatal complications of pregnancy, and its possible relationship to the generalized Shwartzman phenomenon|journal=American Journal of Obstetrics and Gynecology|volume=66|issue=3|year=1953|pages=507–539|issn=00029378|doi=10.1016/0002-9378(53)90068-4}}</ref> It is thought that tissue necrosis results in release of sequestered antigens, precipitating autoimmunity of the pituitary gland and hypopituitarism in Sheehan's syndrome.<ref name="pmid12213861">{{cite journal |vauthors=Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N |title=Pituitary autoimmunity in patients with Sheehan's syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue=9 |pages=4137–41 |year=2002 |pmid=12213861 |doi=10.1210/jc.2001-020242 |url=}}</ref> Type 1 diabetes, pre-existinfg vascular diseases and any pituitary masses are associated with increased risk of developing Sheehan syndrome in pregnancy <ref name="Abourawi2006">{{cite journal|last1=Abourawi|first1=F|title=Diabetes Mellitus and Pregnancy|journal=Libyan Journal of Medicine|volume=1|issue=1|year=2006|pages=28–41|issn=19932820|doi=10.4176/060617}}</ref>
*Anterior pituitary does not have a direct blood supply and is supplied by hypophyseal portal system. The hypophyseal portal system is a fenestrated set of capillaries and allows rapid exchange of hormones between hypothalamus and anterior pituitary. Occlusions and other issues in the blood vessels of the hypophyseal portal system can also cause complications in the exchange of hormones between the hypothalamus and the pituitary gland leading to hypopituitarism.  
*'''Anterior pituitary''' does not have a direct blood supply and is supplied by hypophyseal portal system. The hypophyseal portal system is a fenestrated set of capillaries and allows rapid exchange of hormones between hypothalamus and anterior pituitary. Occlusions and other issues in the blood vessels of the hypophyseal portal system can also cause complications in the exchange of hormones between the hypothalamus and the pituitary gland leading to hypopituitarism.  
*Posterior pituitary has its own blood supply via inferior hypophyseal artery and is less affected compared to anterior pituitary. If affected, can result in neurohypophseal dysfunction and ischemic necrosis of thirst center leading to increased osmotic threshold for thirst onset.<ref name="pmid17468192">{{cite journal |vauthors=Atmaca H, Tanriverdi F, Gokce C, Unluhizarci K, Kelestimur F |title=Posterior pituitary function in Sheehan's syndrome |journal=Eur. J. Endocrinol. |volume=156 |issue=5 |pages=563–7 |year=2007 |pmid=17468192 |doi=10.1530/EJE-06-0727 |url=}}</ref>
*'''Posterior pituitary''' has its own blood supply via inferior hypophyseal artery and is less affected compared to anterior pituitary. If affected, can result in neurohypophseal dysfunction and ischemic necrosis of thirst center leading to increased osmotic threshold for thirst onset.<ref name="pmid17468192">{{cite journal |vauthors=Atmaca H, Tanriverdi F, Gokce C, Unluhizarci K, Kelestimur F |title=Posterior pituitary function in Sheehan's syndrome |journal=Eur. J. Endocrinol. |volume=156 |issue=5 |pages=563–7 |year=2007 |pmid=17468192 |doi=10.1530/EJE-06-0727 |url=}}</ref>
*Severe PPH (loss of >500ml of blood during the first 24hr) leading to hypotension and ischemic necrosis of pituitary gland is the most common cause of Sheehan syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F, Chow YW, Pietranico R, Mukerji A, Wiesmann UN, DiDonato S, Herschkowitz NN, Voigt WG, Johnson CR, Moroi K, Sato T, Keleştimur F, Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N, Wrightstone RN, Smith LL, Wilson JB, Vella F, Huisman TH, Marniemi J, Parkki MG, Ward CW, Stellwagen E, Babul J, Pogodina VV, Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N, Schmoldt A, Benthe HF, Haberland G, Lyons HA, Thomas JS, Heurich AE, Shepherd DA, Wetmore SD, Mekler LB, Sealey JE, White RP, Laragh JH, Rubin AL, Makar AB, McMartin KE, Palese M, Tephly TR, Frankle RT, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Frankle RT, Thornton JA, Harrison MJ, Stellwagen E, Babul J, Leroy M, Loas G, Perez-Diaz F, Schmoldt A, Benthe HF, Haberland G, Coller BS, Franza BR, Gralnick HR |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi=10.1210/jc.2001-020242 |url=}}</ref>  
*Severe PPH (loss of >500ml of blood during the first 24hr) leading to hypotension and ischemic necrosis of pituitary gland is the most common cause of Sheehan syndrome.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F, Chow YW, Pietranico R, Mukerji A, Wiesmann UN, DiDonato S, Herschkowitz NN, Voigt WG, Johnson CR, Moroi K, Sato T, Keleştimur F, Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N, Wrightstone RN, Smith LL, Wilson JB, Vella F, Huisman TH, Marniemi J, Parkki MG, Ward CW, Stellwagen E, Babul J, Pogodina VV, Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N, Schmoldt A, Benthe HF, Haberland G, Lyons HA, Thomas JS, Heurich AE, Shepherd DA, Wetmore SD, Mekler LB, Sealey JE, White RP, Laragh JH, Rubin AL, Makar AB, McMartin KE, Palese M, Tephly TR, Frankle RT, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Makar AB, McMartin KE, Palese M, Tephly TR, Frankle RT, Thornton JA, Harrison MJ, Stellwagen E, Babul J, Leroy M, Loas G, Perez-Diaz F, Schmoldt A, Benthe HF, Haberland G, Coller BS, Franza BR, Gralnick HR |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi=10.1210/jc.2001-020242 |url=}}</ref>  
*Sheehan's syndrome results in mild to severe pituitary dysfunction resulting in partial or panhypopituitarism such as GH, Thyroid hormone, glucocorticoid, gonadotropins(LH, FSH) and prolactin hormone deficiencies that manifests as a wide spectrum of presentation.<ref name="pmid8043090">{{cite journal |vauthors=Vance ML |title=Hypopituitarism |journal=N. Engl. J. Med. |volume=330 |issue=23 |pages=1651–62 |year=1994 |pmid=8043090 |doi=10.1056/NEJM199406093302306 |url=}}</ref> Usually, GH is the earliest one to be lost.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref>
*Sheehan's syndrome results in mild to severe pituitary dysfunction resulting in partial or panhypopituitarism such as GH, Thyroid hormone, glucocorticoid, gonadotropins(LH, FSH) and prolactin hormone deficiencies that manifests as a wide spectrum of presentation.<ref name="pmid8043090">{{cite journal |vauthors=Vance ML |title=Hypopituitarism |journal=N. Engl. J. Med. |volume=330 |issue=23 |pages=1651–62 |year=1994 |pmid=8043090 |doi=10.1056/NEJM199406093302306 |url=}}</ref> Usually, GH is the earliest one to be lost.<ref name="pmid15237929">{{cite journal |vauthors=Keleştimur F |title=Sheehan's syndrome |journal=Pituitary |volume=6 |issue=4 |pages=181–8 |year=2003 |pmid=15237929 |doi= |url=}}</ref>

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Iqra Qamar M.D.[2]

Overview

  • The exact pathogenesis of [disease name] is not fully understood.

OR

  • It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
  • [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
  • Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
  • [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
  • The progression to [disease name] usually involves the [molecular pathway].
  • The pathophysiology of [disease/malignancy] depends on the histological subtype.

Pathophysiology

Pathogenesis

  • Pituitry gland is amongst the most vascularized tissues in the body that normally weighs about 0.5g but gets doubled in size during pregnancy.[1] Pituitary gland enlargement due to hypertrophy and hyperplasia of lactotrophic cells in anterior pituitary resulting in superior hypophyseal artery compression complicated by decreased portal pressure and vasospasm during delivery play an important role in the pathogenesis of Sheehan syndrome.[2]
  • Apart from pituitary gland enlargement during and before parturition, vasospasm, generalized Schwartzman phenomenon,thrombosis and compression of the hypophyseal arteries, autoimmunity, DIC and smaller size of sella are thought to play a contributing role in pathogenesis of sheehan Syndrome.[3][4][5] It is thought that tissue necrosis results in release of sequestered antigens, precipitating autoimmunity of the pituitary gland and hypopituitarism in Sheehan's syndrome.[6] Type 1 diabetes, pre-existinfg vascular diseases and any pituitary masses are associated with increased risk of developing Sheehan syndrome in pregnancy [7]
  • Anterior pituitary does not have a direct blood supply and is supplied by hypophyseal portal system. The hypophyseal portal system is a fenestrated set of capillaries and allows rapid exchange of hormones between hypothalamus and anterior pituitary. Occlusions and other issues in the blood vessels of the hypophyseal portal system can also cause complications in the exchange of hormones between the hypothalamus and the pituitary gland leading to hypopituitarism.
  • Posterior pituitary has its own blood supply via inferior hypophyseal artery and is less affected compared to anterior pituitary. If affected, can result in neurohypophseal dysfunction and ischemic necrosis of thirst center leading to increased osmotic threshold for thirst onset.[8]
  • Severe PPH (loss of >500ml of blood during the first 24hr) leading to hypotension and ischemic necrosis of pituitary gland is the most common cause of Sheehan syndrome.[3]
  • Sheehan's syndrome results in mild to severe pituitary dysfunction resulting in partial or panhypopituitarism such as GH, Thyroid hormone, glucocorticoid, gonadotropins(LH, FSH) and prolactin hormone deficiencies that manifests as a wide spectrum of presentation.[9] Usually, GH is the earliest one to be lost.[3]

Genetics

There is no genetic association found to be associated with Sheehan's syndrome.

Associated Conditions

Sheehan's syndrome is associated with:

  • Pregnancy
  • PPH
  • Hypotension

Gross Pathology

  • On gross pathology,

Microscopic Pathology

On microscopy, the following findings may be observed:

  • Ischemic necrosis leading to scarring of neurohypophysis
  • Scarring of para-ventricular and supra-optic nuclei

References

  1. ↑ Rolih CA, Ober KP (1993). "Pituitary apoplexy". Endocrinol. Metab. Clin. North Am. 22 (2): 291–302. PMID 8325288.
  2. ↑ Scheithauer BW, Sano T, Kovacs KT, Young WF, Ryan N, Randall RV (1990). "The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases". Mayo Clin. Proc. 65 (4): 461–74. PMID 2159093.
  3. ↑ 3.0 3.1 3.2 Keleştimur F (2003). "Sheehan's syndrome". Pituitary. 6 (4): 181–8. PMID 15237929.
  4. ↑ Apitz, Kurt (September 1, 1935). "A Study of the Generalized Shwartzman Phenomenon". The Journal of Immunology. 29 (3): 255–266.
  5. ↑ McKay, Donald G.; Merrill, Samuel J.; Weiner, Albert E.; Hertig, Arthur T.; Reid, Duncan E. (1953). "The pathologic anatomy of eclampsia, bilateral renal cortical necrosis, pituitary necrosis, and other acute fatal complications of pregnancy, and its possible relationship to the generalized Shwartzman phenomenon". American Journal of Obstetrics and Gynecology. 66 (3): 507–539. doi:10.1016/0002-9378(53)90068-4. ISSN 0002-9378.
  6. ↑ Goswami R, Kochupillai N, Crock PA, Jaleel A, Gupta N (2002). "Pituitary autoimmunity in patients with Sheehan's syndrome". J. Clin. Endocrinol. Metab. 87 (9): 4137–41. doi:10.1210/jc.2001-020242. PMID 12213861.
  7. ↑ Abourawi, F (2006). "Diabetes Mellitus and Pregnancy". Libyan Journal of Medicine. 1 (1): 28–41. doi:10.4176/060617. ISSN 1993-2820.
  8. ↑ Atmaca H, Tanriverdi F, Gokce C, Unluhizarci K, Kelestimur F (2007). "Posterior pituitary function in Sheehan's syndrome". Eur. J. Endocrinol. 156 (5): 563–7. doi:10.1530/EJE-06-0727. PMID 17468192.
  9. ↑ Vance ML (1994). "Hypopituitarism". N. Engl. J. Med. 330 (23): 1651–62. doi:10.1056/NEJM199406093302306. PMID 8043090.

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