Diabetes insipidus risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The [[risk factors]] in the development of diabetes insipidus vary depending on the type of DI caused. There are a few [[risk factors]] in the development of [[Central diabetes insipidus|central DI]] which include [[genetic mutations]], [[Pituitary disease|pituitary disorders]], [[hypothalamic]] injury, head [[tumors]]. The most potent [[risk factor]] in the development of [[nephrogenic diabetes insipidus]] is [[lithium]] use; as [[lithium]] has a very narrow [[therapeutic index]] of 0.4-0.8 mmol/L . Excessive water intake has been identified to be the only [[risk factor]] associated with psychogenic DI; also [[pregnancy]] is the for gestational DI. | |||
==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
The following are some of the common risk factors associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= |url=}}</ref><ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref><ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref><ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref><ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref><ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref> | The following are some of the common [[risk factors]] associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= |url=}}</ref><ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref><ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref><ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref><ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref><ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref> | ||
*[[Genetics]] | *[[Genetics]] | ||
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*[[Sickle-cell disease|Sickle cell disease]] | *[[Sickle-cell disease|Sickle cell disease]] | ||
*[[Amyloidosis]] | *[[Amyloidosis]] | ||
*Lithium use | *[[Lithium]] use | ||
===Less Common Risk Factors=== | ===Less Common Risk Factors=== | ||
Some less common risk factors are: | Some less common [[risk factors]] are: | ||
*Male Gender | *Male Gender | ||
*Family | *[[Family history]] of [[nephrogenic diabetes insipidus]] | ||
*Excessive water consumption | *Excessive water consumption | ||
*[[Pregnancy]] | *[[Pregnancy]] | ||
*Drugs like phenothiazine | *Drugs like [[phenothiazine]] | ||
==References== | ==References== | ||
Revision as of 21:25, 22 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
The risk factors in the development of diabetes insipidus vary depending on the type of DI caused. There are a few risk factors in the development of central DI which include genetic mutations, pituitary disorders, hypothalamic injury, head tumors. The most potent risk factor in the development of nephrogenic diabetes insipidus is lithium use; as lithium has a very narrow therapeutic index of 0.4-0.8 mmol/L . Excessive water intake has been identified to be the only risk factor associated with psychogenic DI; also pregnancy is the for gestational DI.
Risk Factors
Common Risk Factors
The following are some of the common risk factors associated with the development of diabetes insipidus:[1][2][3][4][5][6]
- Genetics
- Polycystic kidney disease
- Pituitary disorders
- Hypothalamic injury
- Hypercalcemia
- Head tumors
- Pregnancy
- Sickle cell disease
- Amyloidosis
- Lithium use
Less Common Risk Factors
Some less common risk factors are:
- Male Gender
- Family history of nephrogenic diabetes insipidus
- Excessive water consumption
- Pregnancy
- Drugs like phenothiazine
References
- ↑ Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF (2005). "Causes of reversible nephrogenic diabetes insipidus: a systematic review". Am. J. Kidney Dis. 45 (4): 626–37. PMID 15806465.
- ↑ Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M (2000). "Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants". J. Clin. Invest. 105 (7): 887–95. doi:10.1172/JCI8688. PMC 377482. PMID 10749568.
- ↑ Devonald MA, Karet FE (2004). "Renal epithelial traffic jams and one-way streets". J. Am. Soc. Nephrol. 15 (6): 1370–81. PMID 15153548.
- ↑ Bichet DG (2006). "Hereditary polyuric disorders: new concepts and differential diagnosis". Semin. Nephrol. 26 (3): 224–33. doi:10.1016/j.semnephrol.2006.02.004. PMID 16713495.
- ↑ van Lieburg AF, Knoers NV, Monnens LA (1999). "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus". J. Am. Soc. Nephrol. 10 (9): 1958–64. PMID 10477148.
- ↑ Bockenhauer D, Bichet DG (2015). "Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus". Nat Rev Nephrol. 11 (10): 576–88. doi:10.1038/nrneph.2015.89. PMID 26077742.