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{{Sheehan's syndrome}} | {{Sheehan's syndrome}} | ||
{{CMG}}; {{IQ}} | {{CMG}}; {{AE}}{{IQ}} | ||
==Overview== | ==Overview== | ||
The most common symptoms of Sheehan's sydrome include agalactorrhea and failure to resume menstruation after parturition. Common symptoms include hot flushes, decreased pubic/axillary hair, hypotension, hypoglycemia, features of hypothyroidism, hypoadrenalism and hypogonadism. | The most common symptoms of Sheehan's sydrome include agalactorrhea and failure to resume menstruation after parturition. Common symptoms include hot flushes, decreased pubic/axillary hair, hypotension, hypoglycemia, features of hypothyroidism, hypoadrenalism and hypogonadism. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
The most common symptoms of Sheehan's sydrome include agalactorrhea and failure to resume menstruation after parturition. Common symptoms include hot flushes, decreased pubic/axillary hair, hypotension, hypoglycemia, features of hypothyroidism, hypoadrenalism and hypogonadism.
History and Symptoms
History
Patients with Sheehan syndrome may have a positive history of:
- Severe or massive PPH
- Pituitary mass
- Coagulopathy such as DIC
Common Symptoms
Common symptoms of Sheehan syndrome include:
- Agalactorrhea due to mammary gland atrophy[1]
- Amenorrhea/oligomenorrhea
- Secondary infertility
- Hot flushes
- Decreased/absent pubic or axillary hair[2]
- Hypotension[3]
- Non-specific symptoms such as fatigue, weakness, and dizziness
- Decreased libido
- Features of hypothyroidism, such as:[1]
- Dry skin
- Cold intolerance
- Constipation
- Bradycardia
- Hair loss
- Myxedema
- Delayed relaxation phase of deep tendon reflexes
- Vaginal atrophy
- Cognitive changes including psychosis[4]
- Osteopenia and osteoporosis[5]
- Hypoglycemia and decreased insulin requirement in women with Type 1 Diabetes.
- Growth hormone deficiency
- Adrenal insufficiency causing asthenia, anorexia, hypopigmented areola and weakness.
Less Common Symptoms
Less common symptoms of Sheehan syndrome include:
- Headache[6]
- Refractory hypotension[7][8]
- Sinus sick syndrome and cardiac arrest[9][10][11]
- Generalized seizures due to hyponatremia.[12]
- Central diabetes insipidus.[13][14]
- Optic chiasm compression
- visual field loss
- headache
- ophthalmoplegia
References
- ↑ 1.0 1.1 "Sheehan Syndrome (Sheehan's Syndrome) | SYMPTOMA.com".
- ↑ Gei-Guardia O, Soto-Herrera E, Gei-Brealey A, Chen-Ku CH (2011). "Sheehan syndrome in Costa Rica: clinical experience with 60 cases". Endocr Pract. 17 (3): 337–44. doi:10.4158/EP10145.OR. PMID 21041170.
- ↑ Kaufmann P, Lax SF, Radner H, Eber B, Leuger A, Smolle KH (1995). "Severe hypotension and coma secondary to unrecognized chronic anterior hypophysitis". Intensive Care Med. 21 (10): 847–9. PMID 8557875.
- ↑ Shoib S, Dar MM, Arif T, Bashir H, Bhat MH, Ahmed J (2013). "Sheehan's syndrome presenting as psychosis: a rare clinical presentation". Med J Islam Repub Iran. 27 (1): 35–7. PMC 3592941. PMID 23483784.
- ↑ Chihaoui M, Yazidi M, Chaker F, Belouidhnine M, Kanoun F, Lamine F, Ftouhi B, Sahli H, Slimane H (2016). "Bone Mineral Density in Sheehan's Syndrome; Prevalence of Low Bone Mass and Associated Factors". J Clin Densitom. 19 (4): 413–418. doi:10.1016/j.jocd.2016.02.002. PMID 26993664.
- ↑ Hale B, Habib AS (2014). "Sheehan syndrome: acute presentation with severe headache". Int J Obstet Anesth. 23 (4): 383–6. doi:10.1016/j.ijoa.2014.04.011. PMID 25223643.
- ↑ Liang L, Liu JB, Chen FQ, Zhao J, Zhang XL (2017). "Refractory hypotension induced by Sheehan syndrome with pituitary crisis: A case report". Exp Ther Med. 13 (5): 2097–2101. doi:10.3892/etm.2017.4188. PMC 5443209. PMID 28565814.
- ↑ George A, Phillips M, Sweeney L, Colombo C (2015). "A 56 year old woman with syncope, weakness, and refractory hypotension". BMJ. 350: h3387. PMID 26113625.
- ↑ Bouznad N, Mghari GE, Hattaoui ME, Ansari NE (2017). "[Atypical and rare cardiac revelation about Sheehan's syndrome: A report of three cases]". Ann Cardiol Angeiol (Paris) (in French). doi:10.1016/j.ancard.2016.12.007. PMID 28129900.
- ↑ Zhao D, Zhang Q, Lu J, Zhang G, Lu H, Huang J, Shan Q (2014). "Sick sinus syndrome associated with hypopituitarism: a case report and literature review". J Biomed Res. 28 (5): 429–32. doi:10.7555/JBR.28.20130099. PMC 4197395. PMID 25332716.
- ↑ Cao L, Lu Z, Zheng Y (2014). "Sheehan's syndrome with cardiac arrest: a case report and review of the literature". Neuro Endocrinol. Lett. 35 (5): 352–4. PMID 25275267.
- ↑ Parikh R, Buch V, Makwana M, Buch HN (2016). "The price of a 15-year delay in diagnosis of Sheehan's syndrome". Proc (Bayl Univ Med Cent). 29 (2): 212–3. PMC 4790577. PMID 27034575.
- ↑ Weiner P, Ben-Israel J, Plavnick L (1979). "Sheehan's syndrome with diabetes insipidus. A case study". Isr. J. Med. Sci. 15 (5): 431–3. PMID 447511.
- ↑ Collins ML, O'Brien P, Cline A (1979). "Diabetes insipidus following obstetric shock". Obstet Gynecol. 53 (3 Suppl): 16S–17S. PMID 424117.