Sheehan's syndrome laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
*Laboratory findings consistent with the diagnosis of Sheehan's syndrome include hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, hypophosphatemia, anemia, pancytopenia, eosinophilia, hypoalbuminemia, low fasting plasma glucose etc. | *Laboratory findings consistent with the diagnosis of [[Sheehan's syndrome]] include [[hyponatremia]], [[hypokalemia]], [[hypocalcemia]], [[hypomagnesemia]], [[hypophosphatemia]], [[anemia]], [[pancytopenia]], [[eosinophilia]], [[hypoalbuminemia]], low [[fasting plasma glucose]] etc. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of Sheehan syndrome include: | *Laboratory findings consistent with the diagnosis of Sheehan syndrome include: | ||
**Hyponatremia<ref name="pmid8797063">{{cite journal |vauthors=Shoji M, Kimura T, Ota K, Ohta M, Sato K, Yamamoto T, Funyu T, Mori T, Tateyama M, Abe K |title=Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia |journal=Intern. Med. |volume=35 |issue=5 |pages=427–31 |year=1996 |pmid=8797063 |doi= |url=}}</ref><ref name="pmid1957856">{{cite journal |vauthors=Putterman C, Almog Y, Caraco Y, Gross DJ, Ben-Chetrit E |title=Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia |journal=Am. J. Obstet. Gynecol. |volume=165 |issue=5 Pt 1 |pages=1330–3 |year=1991 |pmid=1957856 |doi= |url=}}</ref><ref name="pmid19705625">{{cite journal |vauthors=Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB |title=A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia |journal=Acta Biomed |volume=80 |issue=1 |pages=73–6 |year=2009 |pmid=19705625 |doi= |url=}}</ref> | **[[Hyponatremia]]<ref name="pmid8797063">{{cite journal |vauthors=Shoji M, Kimura T, Ota K, Ohta M, Sato K, Yamamoto T, Funyu T, Mori T, Tateyama M, Abe K |title=Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia |journal=Intern. Med. |volume=35 |issue=5 |pages=427–31 |year=1996 |pmid=8797063 |doi= |url=}}</ref><ref name="pmid1957856">{{cite journal |vauthors=Putterman C, Almog Y, Caraco Y, Gross DJ, Ben-Chetrit E |title=Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia |journal=Am. J. Obstet. Gynecol. |volume=165 |issue=5 Pt 1 |pages=1330–3 |year=1991 |pmid=1957856 |doi= |url=}}</ref><ref name="pmid19705625">{{cite journal |vauthors=Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB |title=A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia |journal=Acta Biomed |volume=80 |issue=1 |pages=73–6 |year=2009 |pmid=19705625 |doi= |url=}}</ref> | ||
**Hypokalemia | **[[Hypokalemia]] | ||
**Hypocalcemia | **[[Hypocalcemia]] | ||
**Hypomagnesemia | **[[Hypomagnesemia]] | ||
**Hypophosphatemia | **[[Hypophosphatemia]] | ||
**Anemia<ref name="pmid19705625">{{cite journal |vauthors=Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB |title=A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia |journal=Acta Biomed |volume=80 |issue=1 |pages=73–6 |year=2009 |pmid=19705625 |doi= |url=}}</ref> | **[[Anemia]]<ref name="pmid19705625">{{cite journal |vauthors=Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB |title=A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia |journal=Acta Biomed |volume=80 |issue=1 |pages=73–6 |year=2009 |pmid=19705625 |doi= |url=}}</ref> | ||
**Pancytopenia<ref name="pmid19697029">{{cite journal |vauthors=Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH |title=Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review) |journal=Ann. Hematol. |volume=89 |issue=3 |pages=305–8 |year=2010 |pmid=19697029 |doi=10.1007/s00277-009-0804-9 |url=}}</ref> | **[[Pancytopenia]]<ref name="pmid19697029">{{cite journal |vauthors=Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH |title=Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review) |journal=Ann. Hematol. |volume=89 |issue=3 |pages=305–8 |year=2010 |pmid=19697029 |doi=10.1007/s00277-009-0804-9 |url=}}</ref> | ||
**Eosinophilia<ref name="pmid2723566">{{cite journal |vauthors=Ratarasarn C, Rajatanavin R, Himathongkam T |title=Salient clinical features of Sheehan's syndrome |journal=J Med Assoc Thai |volume=72 |issue=1 |pages=41–7 |year=1989 |pmid=2723566 |doi= |url=}}</ref> | **[[Eosinophilia]]<ref name="pmid2723566">{{cite journal |vauthors=Ratarasarn C, Rajatanavin R, Himathongkam T |title=Salient clinical features of Sheehan's syndrome |journal=J Med Assoc Thai |volume=72 |issue=1 |pages=41–7 |year=1989 |pmid=2723566 |doi= |url=}}</ref> | ||
**Hypoalbuminemia | **[[Hypoalbuminemia]] | ||
**Low fasting plasma glucose | **Low [[fasting plasma glucose]] | ||
**Elevated serum SGOT | **Elevated serum [[SGOT]] | ||
**Thrombocytopenia | **[[Thrombocytopenia]] | ||
**Decreased levels of anterior pituitary hormones in blood. | **Decreased levels of [[anterior pituitary]] [[hormones]] in blood. | ||
*Most sensitive test is inadequate prolactin and gonadotropin responses to stimulation. | *Most sensitive test is inadequate [[prolactin]] and [[gonadotropin]] responses to stimulation. | ||
*Baseline and stimulated anterior pituitary hormone level measurements. | *Baseline and stimulated anterior pituitary hormone level measurements. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Iqra Qamar M.D.[2]
Overview
- Laboratory findings consistent with the diagnosis of Sheehan's syndrome include hyponatremia, hypokalemia, hypocalcemia, hypomagnesemia, hypophosphatemia, anemia, pancytopenia, eosinophilia, hypoalbuminemia, low fasting plasma glucose etc.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of Sheehan syndrome include:
- Hyponatremia[1][2][3]
- Hypokalemia
- Hypocalcemia
- Hypomagnesemia
- Hypophosphatemia
- Anemia[3]
- Pancytopenia[4]
- Eosinophilia[5]
- Hypoalbuminemia
- Low fasting plasma glucose
- Elevated serum SGOT
- Thrombocytopenia
- Decreased levels of anterior pituitary hormones in blood.
- Most sensitive test is inadequate prolactin and gonadotropin responses to stimulation.
- Baseline and stimulated anterior pituitary hormone level measurements.
References
- ↑ Shoji M, Kimura T, Ota K, Ohta M, Sato K, Yamamoto T, Funyu T, Mori T, Tateyama M, Abe K (1996). "Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia". Intern. Med. 35 (5): 427–31. PMID 8797063.
- ↑ Putterman C, Almog Y, Caraco Y, Gross DJ, Ben-Chetrit E (1991). "Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia". Am. J. Obstet. Gynecol. 165 (5 Pt 1): 1330–3. PMID 1957856.
- ↑ 3.0 3.1 Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB (2009). "A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia". Acta Biomed. 80 (1): 73–6. PMID 19705625.
- ↑ Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH (2010). "Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review)". Ann. Hematol. 89 (3): 305–8. doi:10.1007/s00277-009-0804-9. PMID 19697029.
- ↑ Ratarasarn C, Rajatanavin R, Himathongkam T (1989). "Salient clinical features of Sheehan's syndrome". J Med Assoc Thai. 72 (1): 41–7. PMID 2723566.