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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
* In the case of failed imaging investigations to diagnose insulinoma, calcium gluconate injection test is done. | * In the case of failed imaging investigations to diagnose [[insulinoma]], [[calcium gluconate]] injection test is done. | ||
* The test can be performed to distinguish between insulinoma and islet- | * The test can be performed to distinguish between [[insulinoma]] and islet-cell [[Hypertrophy (medical)|hypertrophy]] as follow: | ||
**Injection | **Injection of [[calcium gluconate]] into [[Splanchnic|splanchnic arteries]] and venous sampling searching for [[insulin]].<ref name="pmid26312578">{{cite journal| author=Thompson SM, Vella A, Thompson GB, Rumilla KM, Service FJ, Grant CS et al.| title=Selective Arterial Calcium Stimulation With Hepatic Venous Sampling Differentiates Insulinoma From Nesidioblastosis. | journal=J Clin Endocrinol Metab | year= 2015 | volume= 100 | issue= 11 | pages= 4189-97 | pmid=26312578 | doi=10.1210/jc.2015-2404 | pmc=4702445 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26312578 }}</ref> | ||
**In insulinoma, the test is positive in one artery alone. | **In [[insulinoma]], the test is positive in one artery alone. | ||
**Islet-cell hypertrophy, the test is positive is positive in multiple arteries.<ref name="pmid25873534">{{cite journal| author=Thompson SM, Vella A, Service FJ, Grant CS, Thompson GB, Andrews JC| title=Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma. | journal=Surgery | year= 2015 | volume= 158 | issue= 1 | pages= 162-72 | pmid=25873534 | doi=10.1016/j.surg.2015.03.004 | pmc=4461470 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25873534 }}</ref> | **Islet-cell hypertrophy, the test is positive is positive in multiple arteries.<ref name="pmid25873534">{{cite journal| author=Thompson SM, Vella A, Service FJ, Grant CS, Thompson GB, Andrews JC| title=Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma. | journal=Surgery | year= 2015 | volume= 158 | issue= 1 | pages= 162-72 | pmid=25873534 | doi=10.1016/j.surg.2015.03.004 | pmc=4461470 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25873534 }}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:09, 25 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Other diagnostic studies include injection of calcium gluconate into splanchnic arteries and venous sampling searching for insulin.
Other Diagnostic Studies
- In the case of failed imaging investigations to diagnose insulinoma, calcium gluconate injection test is done.
- The test can be performed to distinguish between insulinoma and islet-cell hypertrophy as follow:
- Injection of calcium gluconate into splanchnic arteries and venous sampling searching for insulin.[1]
- In insulinoma, the test is positive in one artery alone.
- Islet-cell hypertrophy, the test is positive is positive in multiple arteries.[2]
References
- ↑ Thompson SM, Vella A, Thompson GB, Rumilla KM, Service FJ, Grant CS; et al. (2015). "Selective Arterial Calcium Stimulation With Hepatic Venous Sampling Differentiates Insulinoma From Nesidioblastosis". J Clin Endocrinol Metab. 100 (11): 4189–97. doi:10.1210/jc.2015-2404. PMC 4702445. PMID 26312578.
- ↑ Thompson SM, Vella A, Service FJ, Grant CS, Thompson GB, Andrews JC (2015). "Impact of variant pancreatic arterial anatomy and overlap in regional perfusion on the interpretation of selective arterial calcium stimulation with hepatic venous sampling for preoperative localization of occult insulinoma". Surgery. 158 (1): 162–72. doi:10.1016/j.surg.2015.03.004. PMC 4461470. PMID 25873534.