Cushing's syndrome natural history, complications and prognosis: Difference between revisions
| Line 13: | Line 13: | ||
*[[Diabetes mellitus]] | *[[Diabetes mellitus]] | ||
*[[Osteoporosis]] | *[[Osteoporosis]] | ||
* Cardiovascular complications | * Cardiovascular complications: | ||
**[[Hypertension]] | **[[Hypertension]] | ||
**[[Myocardial infarction]] | **[[Myocardial infarction]] | ||
Revision as of 17:51, 29 August 2017
|
Cushing's syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Cushing's syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Cushing's syndrome natural history, complications and prognosis |
|
FDA on Cushing's syndrome natural history, complications and prognosis |
|
CDC on Cushing's syndrome natural history, complications and prognosis |
|
Cushing's syndrome natural history, complications and prognosis in the news |
|
Blogs on Cushing's syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Cushing's disease can lead to diabetes, cardiovascular and psychiatric complications. The prognosis depends on the severity of the disease.
Complications
Cushing's syndrome can lead to the following complications:[1][2]
- Insulin resistance (especially common in ectopic ACTH production)
- Hyperglycemia (high blood sugars)
- Diabetes mellitus
- Osteoporosis
- Cardiovascular complications:
- Hypercoagulable state as a result of:
- Activated coagulation cascade
- Impaired fibrinolysis.
- Major depression
- Anxiety disorders
- Opportunistic infections
- Sepsis
Prognosis
The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of tumors may recur. Mortality in the patients with Cushing's syndrome is increased even after the apparently successful treatment.[3]
References
- ↑ Lacroix A, Feelders RA, Stratakis CA, Nieman LK (2015). "Cushing's syndrome". Lancet. 386 (9996): 913–27. doi:10.1016/S0140-6736(14)61375-1. PMID 26004339.
- ↑ "Increased risk of osteoporotic fractures in patients with Cushing's syndrome".
- ↑ Lodish M (2015). "Cushing's syndrome in childhood: update on genetics, treatment, and outcomes". Curr Opin Endocrinol Diabetes Obes. 22 (1): 48–54. doi:10.1097/MED.0000000000000127. PMC 4415092. PMID 25517021.