Pheochromocytoma epidemiology and demographics: Difference between revisions
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* Annually reported cases range from 500 to 1600 in the United States.<ref name="pmid20664475">{{cite journal| author=Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K et al.| title=The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. | journal=Pancreas | year= 2010 | volume= 39 | issue= 6 | pages= 775-83 | pmid=20664475 | doi=10.1097/MPA.0b013e3181ebb4f0 | pmc=3419007 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20664475 }}</ref> | * Annually reported cases range from 500 to 1600 in the United States.<ref name="pmid20664475">{{cite journal| author=Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K et al.| title=The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. | journal=Pancreas | year= 2010 | volume= 39 | issue= 6 | pages= 775-83 | pmid=20664475 | doi=10.1097/MPA.0b013e3181ebb4f0 | pmc=3419007 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20664475 }}</ref> | ||
* [[Autopsy]] studies have discovered a higher number of cases than the actual [[prevalence]] rates.10 percent of pheochromocytomas are discovered by chance. | * [[Autopsy]] studies have discovered a higher number of cases than the actual [[prevalence]] rates.10 percent of pheochromocytomas are discovered by chance. | ||
=== Prevalence === | |||
* The prevalence of PPGL in patients with hypertension in general outpatient clinics varies between 0.2 and 0.6% (5– 8). | |||
* In children with hypertension, the prevalence of PPGL is approximately 1.7% (12). | |||
* Nearly 5% of patients with incidentally discovered adrenal masses on anatomical imaging prove to have a pheochromocytoma (13, 14). | |||
* The prevalence of PPGL in individuals carrying a germline mutation in PPGL susceptibility genes may be around 50%. | |||
* Patients with hereditary PPGLs typically present with multifocal disease and at a younger age than those with sporadic neoplasms (15, 16). | |||
=== Age === | === Age === | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Mohammed Abdelwahed M.D[3]
Overview
The incidence of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to a high of 0.8 per 100,000 persons. The average age at diagnosis is 24.9 years in familial cases and 43.9 years in sporadic cases. The prevalence and incidence of pheochromocytoma does not vary by gender.
Epidemiology and Demographics
Incidence
- In the USA, the incidence of pheochromocytoma ranges from a low of 0.2 per 100,000 persons to a high of 0.8 per 100,000 persons.[1].
- Annually reported cases range from 500 to 1600 in the United States.[2]
- Autopsy studies have discovered a higher number of cases than the actual prevalence rates.10 percent of pheochromocytomas are discovered by chance.
Prevalence
- The prevalence of PPGL in patients with hypertension in general outpatient clinics varies between 0.2 and 0.6% (5– 8).
- In children with hypertension, the prevalence of PPGL is approximately 1.7% (12).
- Nearly 5% of patients with incidentally discovered adrenal masses on anatomical imaging prove to have a pheochromocytoma (13, 14).
- The prevalence of PPGL in individuals carrying a germline mutation in PPGL susceptibility genes may be around 50%.
- Patients with hereditary PPGLs typically present with multifocal disease and at a younger age than those with sporadic neoplasms (15, 16).
Age
- The peak incidence of pheochromocytoma occurs in third decades of life; the average age at diagnosis is 24.9 years in hereditary cases and 43.9 years in sporadic cases.[1]
- Hereditary tumors present at a younger age than sporadic.
- Approximately 10% occur in children.
Race
- Pheochromocytomas occur across all races but is found less commonly in blacks.
Gender
- The prevalence and incidence of pheochromocytoma does not vary by gender.[1]
References
- ↑ 1.0 1.1 1.2 National Cancer Institute. Physician Data Query Database 2015. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc
- ↑ Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K; et al. (2010). "The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer". Pancreas. 39 (6): 775–83. doi:10.1097/MPA.0b013e3181ebb4f0. PMC 3419007. PMID 20664475.