Hashimoto's thyroiditis causes: Difference between revisions
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==Overview== | ==Overview== | ||
Hashimoto's thyroiditis may be caused by [[T cell|T cells]] and [[B cell|B cells]] auto activation, genetic factors, and autoimmune antibodies against [[Thyrotropin receptor|thyrotropin receptors]]. | Hashimoto's thyroiditis may be caused by [[T cell|T cells]] and [[B cell|B cells]] auto activation, [[genetic]] factors, and autoimmune antibodies against [[Thyrotropin receptor|thyrotropin receptors]]. | ||
==Causes== | ==Causes== | ||
[[Hashimoto's thyroiditis|Hashimoto's thyroidit]]<nowiki/>is usually caused by:<ref name="pmid26361257">{{cite journal |vauthors=Ajjan RA, Weetman AP |title=The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding |journal=Horm. Metab. Res. |volume=47 |issue=10 |pages=702–10 |year=2015 |pmid=26361257 |doi=10.1055/s-0035-1548832 |url=}}</ref> | [[Hashimoto's thyroiditis|Hashimoto's thyroidit]]<nowiki/>is usually caused by:<ref name="pmid26361257">{{cite journal |vauthors=Ajjan RA, Weetman AP |title=The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding |journal=Horm. Metab. Res. |volume=47 |issue=10 |pages=702–10 |year=2015 |pmid=26361257 |doi=10.1055/s-0035-1548832 |url=}}</ref> | ||
===Common causes=== | ===Common causes=== | ||
*[[ | *Autoantibodies against [[thyroid peroxidase]] and [[thyroglobulin]]. | ||
*Abnormalities in the [[suppressor T cells]] and [[Regulatory T cell|regulatory T cells]]. | *Abnormalities in the [[suppressor T cells]] and [[Regulatory T cell|regulatory T cells]]. | ||
*HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement. | *HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement. | ||
===Less common cause=== | ===Less common cause=== | ||
*Immunomodulatory drugs (e.g, [[interferon-alpha]].) | *[[Immunomodulatory]] drugs (e.g, [[interferon-alpha]].) | ||
*[[Monoclonal antibodies]] that block [[CTLA-4]] | *[[Monoclonal antibodies]] that block [[CTLA-4]] | ||
*Cancer vaccines | *[[Cancer]] vaccines | ||
*[[MicroRNA|Micro RNA]] involvement | *[[MicroRNA|Micro RNA]] involvement | ||
*[[Polyglandular autoimmune syndrome|Polyglandular Syndrome]] | *[[Polyglandular autoimmune syndrome|Polyglandular Syndrome]] | ||
Revision as of 16:25, 31 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Hashimoto's thyroiditis may be caused by T cells and B cells auto activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.
Causes
Hashimoto's thyroiditis usually caused by:[1]
Common causes
- Autoantibodies against thyroid peroxidase and thyroglobulin.
- Abnormalities in the suppressor T cells and regulatory T cells.
- HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement.
Less common cause
- Immunomodulatory drugs (e.g, interferon-alpha.)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Micro RNA involvement
- Polyglandular Syndrome
For the factors involved in the development of Hashimoto's thyroiditis, please click here.
References
- ↑ Ajjan RA, Weetman AP (2015). "The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding". Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.