Celiac disease causes: Difference between revisions
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==Causes== | ==Causes== | ||
The common causes of celiac disease are autoantibodies to [[gluten]] and certain [[HLA-DQ|genetic factors]].<ref name="pmid19394538">{{cite journal |vauthors=Di Sabatino A, Corazza GR |title=Coeliac disease |journal=Lancet |volume=373 |issue=9673 |pages=1480–93 |year=2009 |pmid=19394538 |doi=10.1016/S0140-6736(09)60254-3 |url=}}</ref><ref name="pmid19443237">{{cite journal |vauthors=Heap GA, van Heel DA |title=Genetics and pathogenesis of coeliac disease |journal=Semin. Immunol. |volume=21 |issue=6 |pages=346–54 |year=2009 |pmid=19443237 |doi=10.1016/j.smim.2009.04.001 |url=}}</ref> | |||
===Common Causes=== | ===Common Causes=== | ||
Celiac disease is usually caused by: | Celiac disease is usually caused by: | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.
Causes
The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.[1][2]
Common Causes
Celiac disease is usually caused by:
- Autoantibodies against gluten which is found in:
- Wheat
- Barley
- Rye
Genetic Causes
- Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
- CELIAC1 (6p21)
- Non-HLA genes are also thought to be related to celiac disease:
- CELIAC2 (5q31-33)
- CELIAC3 (2q33)
- CELIAC4 (19p13·1)
References
- ↑ Di Sabatino A, Corazza GR (2009). "Coeliac disease". Lancet. 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254-3. PMID 19394538.
- ↑ Heap GA, van Heel DA (2009). "Genetics and pathogenesis of coeliac disease". Semin. Immunol. 21 (6): 346–54. doi:10.1016/j.smim.2009.04.001. PMID 19443237.