Neurosyphilis pathophysiology

Neurosyphilis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Neurosyphilis is caused by Treponema pallidum, the bacteria that cause syphilis. It usually occurs about 10 - 20 years after a person is first infected with syphilis. Not everyone who has syphilis will develop this complication.

Pathophysiology

Neurosyphilis is caused by Treponema pallidum, the bacteria that cause syphilis. It usually occurs about 10 - 20 years after a person is first infected with syphilis. Not everyone who has syphilis will develop this complication.

There are four different forms of neurosyphilis:

• Asymptomatic (most common form)
• General paresis
• Meningovascular
• Tabes dorsalis

Asymptomatic neurosyphilis occurs before symptomatic syphilis.