Adrenocortical carcinoma radiation therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Radiation therapyand radiofrequency ablation may be used for palliation in patients who are not surgical candidates.

Radiation Therapy

Radiotherapy has shown improvement in both the adjuvant and palliative ACCs.

Radiation therapy in non metastatic ACC

• According to the National Cancer Data Base and the The Surveillance, Epidemiology, and End Results program, there is an evidence that radiotherapy might be effective. (4, 11, 90).
• Local recurrence-free survival was 86% in the group that received radiation compared with11%in those that did not (332).
• Radiotherapy also can be used for treating unresectable masses. (247).

Radiation therapy for palliation

• Seventy seven percent of patients with metastatic ACCs to bone experienced adequate palliation of pain after radiotherapy with dosages totaling 10 to 60 Gy. (336) (334)
• Radiofrequency ablation (RFA) and transarterial chemoembolization are an alternative to surgery, when surgery is not desired or contraindicated.
• High local tumor regression can be achieved can be achieved with minimal systemic side effects. (357)
• Bleeding is one of the complications as adrenal tumors have a tendency to undergo hemorrhage. (356).