Adrenocortical carcinoma natural history: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
Adrenocortical carcinoma, generally, carries a poor prognosis.<ref name="allolio">{{cite journal | author = Allolio B, Fassnacht M | title = Clinical review: Adrenocortical carcinoma: clinical update. | journal = J Clin Endocrinol Metab | volume = 91 | issue = 6 | pages = 2027-37 | year = 2006 | id = PMID 16551738}} [http://jcem.endojournals.org/cgi/content/full/91/6/2027 Free Full Text].</ref> | Adrenocortical carcinoma, generally, carries a poor prognosis.<ref name="allolio">{{cite journal | author = Allolio B, Fassnacht M | title = Clinical review: Adrenocortical carcinoma: clinical update. | journal = J Clin Endocrinol Metab | volume = 91 | issue = 6 | pages = 2027-37 | year = 2006 | id = PMID 16551738}} [http://jcem.endojournals.org/cgi/content/full/91/6/2027 Free Full Text].</ref> | ||
The five-year disease-free survival rate for a complete resection of a [[Cancer staging|stage]] I-III is approximately 30%.<ref name="allolio" /> | The five-year disease-free survival rate for a complete resection of a [[Cancer staging|stage]] I-III is approximately 30%.<ref name="allolio" /> | ||
The most important prognostic factors are: | The most important prognostic factors are: | ||
* Age of the patient | * Age of the patient (243). | ||
* Stage of the tumor | * Stage of the tumor (243, 244) | ||
* Mitotic activity | * Mitotic activity (245). | ||
* Venous invasion | * Venous invasion | ||
* Weight more than 50 Kg | * Weight more than 50 Kg | ||
* Diameter more than 6.5 cm | * Diameter more than 6.5 cm | ||
* Cortisol production as an adverse prognostic factor (12, 85, 244). | |||
* Ki-67/MIB1 labeling index (antigen identified by monoclonal antibody Ki-67) | * Ki-67/MIB1 labeling index (antigen identified by monoclonal antibody Ki-67) | ||
* Survival ranges from a few months to several years. (242) | * Survival ranges from a few months to several years. (242) | ||
==References== | ==References== | ||
Revision as of 19:07, 21 September 2017
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Diagnosis |
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Case Study |
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Adrenocortical carcinoma natural history On the Web |
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American Roentgen Ray Society Images of Adrenocortical carcinoma natural history |
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Risk calculators and risk factors for Adrenocortical carcinoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3]
Overview
Prognosis is generally poor, and the 5-year survival rate of patients with adrenocortical carcinoma stage I-III is approximately 30%. Complication may include metastasis, Conn syndrom and Cushing syndrom
Complications
The following are the complications of Adrenocortical carcinoma:
- Cushing's syndrome
- Conn syndrome
- Hypertension
- Local and distant metastasis
- Paraneoplastic syndrome
- Tumor thrombus formation
Prognosis
Adrenocortical carcinoma, generally, carries a poor prognosis.[1]
The five-year disease-free survival rate for a complete resection of a stage I-III is approximately 30%.[1]
The most important prognostic factors are:
- Age of the patient (243).
- Stage of the tumor (243, 244)
- Mitotic activity (245).
- Venous invasion
- Weight more than 50 Kg
- Diameter more than 6.5 cm
- Cortisol production as an adverse prognostic factor (12, 85, 244).
- Ki-67/MIB1 labeling index (antigen identified by monoclonal antibody Ki-67)
- Survival ranges from a few months to several years. (242)
References
- ↑ 1.0 1.1 Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. PMID 16551738. Free Full Text.