Adrenocortical carcinoma history and symptoms: Difference between revisions
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==Common Symptoms== | ==Common Symptoms== | ||
60 percent of [[adrenocortical carcinoma]] (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.<ref name="pmid16551738">{{cite journal| author=Allolio B, Fassnacht M| title=Clinical review: Adrenocortical carcinoma: clinical update. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 6 | pages= 2027-37 | pmid=16551738 | doi=10.1210/jc.2005-2639 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16551738 }}</ref> | 60 percent of [[adrenocortical carcinoma]] (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.<ref name="pmid16551738">{{cite journal| author=Allolio B, Fassnacht M| title=Clinical review: Adrenocortical carcinoma: clinical update. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 6 | pages= 2027-37 | pmid=16551738 | doi=10.1210/jc.2005-2639 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16551738 }}</ref> | ||
* Forty-five percent of ACCs show symptoms of Cushing's syndrome alone | * Forty-five percent of ACCs show symptoms of [[Cushing's syndrome]] alone | ||
* Twenty-five percent present with mixed overproduction of both glucocorticoids and androgens.<ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640 }}</ref> | * Twenty-five percent present with mixed overproduction of both [[glucocorticoids]] and [[androgens]].<ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640 }}</ref> | ||
* Ten percent present with virilization alone | * Ten percent present with [[virilization]] alone | ||
1- Symptoms of [[glucocorticoid]] excess include: | 1- Symptoms of [[glucocorticoid]] excess include: | ||
*[[Weight gain]] | *[[Weight gain]] | ||
| Line 15: | Line 15: | ||
*[[Insomnia]] | *[[Insomnia]] | ||
2- Symptoms of [[androgen]] excess symptoms ( | 2- Symptoms of [[androgen]] excess symptoms (especially among women) include: | ||
*[[Hirsutism|Excess facial and body hair]] | *[[Hirsutism|Excess facial and body hair]] | ||
*[[Acne]] | *[[Acne]] | ||
| Line 26: | Line 26: | ||
*[[Confusion]] | *[[Confusion]] | ||
*[[Palpitations]] | *[[Palpitations]] | ||
4- Symptoms of [[estrogen]] excess ( | 4- Symptoms of [[estrogen]] excess (especially among men) include: | ||
*[[Gynecomastia]] | *[[Gynecomastia]] | ||
*Decreased [[libido]] | *Decreased [[libido]] | ||
| Line 37: | Line 37: | ||
6- Other symptoms may include:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref> | 6- Other symptoms may include:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref> | ||
*Abdominal lump | *[[Abdominal mass|Abdominal lump]] | ||
*Abdominal or back pain | *Abdominal or [[back pain]] | ||
*Abdominal fullness | *Abdominal fullness | ||
Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%).<ref name="pmid15137014">{{cite journal| author=Stewart JN, Flageole H, Kavan P| title=A surgical approach to adrenocortical tumors in children: the mainstay of treatment. | journal=J Pediatr Surg | year= 2004 | volume= 39 | issue= 5 | pages= 759-63 | pmid=15137014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15137014 }}</ref> | Children usually present with [[virilization]] (84%), while isolated [[glucocorticoid]] excess is much less common (6%).<ref name="pmid15137014">{{cite journal| author=Stewart JN, Flageole H, Kavan P| title=A surgical approach to adrenocortical tumors in children: the mainstay of treatment. | journal=J Pediatr Surg | year= 2004 | volume= 39 | issue= 5 | pages= 759-63 | pmid=15137014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15137014 }}</ref> | ||
==References== | ==References== | ||
Revision as of 16:26, 24 September 2017
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Adrenocortical carcinoma history and symptoms On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess.
Common Symptoms
60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]
- Forty-five percent of ACCs show symptoms of Cushing's syndrome alone
- Twenty-five percent present with mixed overproduction of both glucocorticoids and androgens.[2]
- Ten percent present with virilization alone
1- Symptoms of glucocorticoid excess include:
2- Symptoms of androgen excess symptoms (especially among women) include:
- Excess facial and body hair
- Acne
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation
3- Symptoms of mineralcorticoid excess include:
4- Symptoms of estrogen excess (especially among men) include:
- Gynecomastia
- Decreased libido
- Impotence
5- symptoms of catecholamines excess has been reported in adrenocortical cancers:[3]
6- Other symptoms may include:[4]
- Abdominal lump
- Abdominal or back pain
- Abdominal fullness
Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%).[5]
References
- ↑ Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
- ↑ Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1
- ↑ Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.