Adrenocortical carcinoma laboratory findings: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 11: | Line 11: | ||
!labs | !labs | ||
|- | |- | ||
|Cortisol | | '''Cortisol''' | ||
| | | | ||
*Cortisol level | *[[Cortisol level]] | ||
*ACTH (10 pg/mL) | *[[Adrenocorticotropic hormone|ACTH]] (10 pg/mL) | ||
*24-hour urinary free cortisol | *24-hour urinary free cortisol | ||
*Fasting serum cortisol at 8 AM following a 1 mg dose of dexamethasone at bedtime | *Fasting serum [[cortisol]] at 8 AM following a 1 mg dose of [[dexamethasone]] at bedtime | ||
|- | |- | ||
|'''Steroids'''<ref name="pmid19500769">{{cite journal| author=Fassnacht M, Allolio B| title=Clinical management of adrenocortical carcinoma. | journal=Best Pract Res Clin Endocrinol Metab | year= 2009 | volume= 23 | issue= 2 | pages= 273-89 | pmid=19500769 | doi=10.1016/j.beem.2008.10.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19500769 }}</ref> | |'''Steroids'''<ref name="pmid19500769">{{cite journal| author=Fassnacht M, Allolio B| title=Clinical management of adrenocortical carcinoma. | journal=Best Pract Res Clin Endocrinol Metab | year= 2009 | volume= 23 | issue= 2 | pages= 273-89 | pmid=19500769 | doi=10.1016/j.beem.2008.10.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19500769 }}</ref> | ||
| | | | ||
* Adrenal androgens [DHEAS] | * [[Androgen|Adrenal androgens]] [[[DHEAS]]] | ||
* Androstenedione | * [[Androstenedione]] | ||
* Bioavailable testosterone should be measured in every patient. | * Bioavailable [[testosterone]] should be measured in every patient. | ||
* 17-hydroxyprogesterone | * [[17-Hydroxyprogesterone|17-hydroxyprogesterone]] | ||
* Serum estradiol in men and postmenopausal women | * Serum [[estradiol]] in men and [[postmenopausal]] women | ||
* A recent study has shown significant differences in steroid | * A recent study has shown significant differences in [[steroid hormones]] precursor and metabolite profiles in urine of patients with ACC compared with patients with [[Adrenocortical adenoma|benign adrenal tumors]]. | ||
|- | |- | ||
|'''Epinephrine'''<ref name="pmid21385478">{{cite journal| author=Song G, Joe BN, Yeh BM, Meng MV, Westphalen AC, Coakley FV| title=Risk of catecholamine crisis in patients undergoing resection of unsuspected pheochromocytoma. | journal=Int Braz J Urol | year= 2011 | volume= 37 | issue= 1 | pages= 35-40;discussion 40-1 | pmid=21385478 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21385478 }}</ref> | |'''Epinephrine'''<ref name="pmid21385478">{{cite journal| author=Song G, Joe BN, Yeh BM, Meng MV, Westphalen AC, Coakley FV| title=Risk of catecholamine crisis in patients undergoing resection of unsuspected pheochromocytoma. | journal=Int Braz J Urol | year= 2011 | volume= 37 | issue= 1 | pages= 35-40;discussion 40-1 | pmid=21385478 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21385478 }}</ref> | ||
| | | | ||
* Metanephrine and normetanephrine in plasma or 24-hour urine | * [[Metanephrine]] and [[normetanephrine]] in plasma or 24-hour urine | ||
|- | |- | ||
|'''Aldosterone'''<ref name="pmid21917861">{{cite journal| author=Arlt W, Biehl M, Taylor AE, Hahner S, Libé R, Hughes BA et al.| title=Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. | journal=J Clin Endocrinol Metab | year= 2011 | volume= 96 | issue= 12 | pages= 3775-84 | pmid=21917861 | doi=10.1210/jc.2011-1565 | pmc=3232629 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21917861 }}</ref> | |'''Aldosterone'''<ref name="pmid21917861">{{cite journal| author=Arlt W, Biehl M, Taylor AE, Hahner S, Libé R, Hughes BA et al.| title=Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. | journal=J Clin Endocrinol Metab | year= 2011 | volume= 96 | issue= 12 | pages= 3775-84 | pmid=21917861 | doi=10.1210/jc.2011-1565 | pmc=3232629 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21917861 }}</ref> | ||
| | | | ||
* Low serum aldosterone concentrations, normal or high serum or urinary concentrations of aldosterone precursors | * Low serum [[aldosterone]] concentrations, normal or high serum or urinary concentrations of aldosterone precursors | ||
|} | |} | ||
Revision as of 16:31, 24 September 2017
|
Adrenocortical carcinoma Microchapters |
|
Differentiating Adrenocortical carcinoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Study |
|
Adrenocortical carcinoma laboratory findings On the Web |
|
American Roentgen Ray Society Images of Adrenocortical carcinoma laboratory findings |
|
Risk calculators and risk factors for Adrenocortical carcinoma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Some patients with adrenocortical carcinoma may have elevated concentration of serum cortisol, aldosterone, testosterone or estrogen and reduced concentration of plasma renin and potassium.
Laboratory Findings
Laboratory findings that may associate adrenocortical carcinoma are:
| Hormonal disturbance | labs |
|---|---|
| Cortisol |
|
| Steroids[1] |
|
| Epinephrine[2] |
|
| Aldosterone[3] |
|
References
- ↑ Fassnacht M, Allolio B (2009). "Clinical management of adrenocortical carcinoma". Best Pract Res Clin Endocrinol Metab. 23 (2): 273–89. doi:10.1016/j.beem.2008.10.008. PMID 19500769.
- ↑ Song G, Joe BN, Yeh BM, Meng MV, Westphalen AC, Coakley FV (2011). "Risk of catecholamine crisis in patients undergoing resection of unsuspected pheochromocytoma". Int Braz J Urol. 37 (1): 35–40, discussion 40-1. PMID 21385478.
- ↑ Arlt W, Biehl M, Taylor AE, Hahner S, Libé R, Hughes BA; et al. (2011). "Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors". J Clin Endocrinol Metab. 96 (12): 3775–84. doi:10.1210/jc.2011-1565. PMC 3232629. PMID 21917861.