Adrenocortical carcinoma radiation therapy: Difference between revisions
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[[Radiation therapy]]and [[radiofrequency ablation]] may be used for [[palliative care|palliation]] in patients who are not surgical candidates. | [[Radiation therapy]]and [[radiofrequency ablation]] may be used for [[palliative care|palliation]] in patients who are not surgical candidates. | ||
==Radiation Therapy== | ==Radiation Therapy== | ||
Radiotherapy has shown improvement in both the adjuvant and palliative ACCs. | [[Radiotherapy]] has shown improvement in both the [[Adjuvant treatment|adjuvant]] and [[Palliative care|palliative]] ACCs. | ||
==== '''''Radiation therapy in non metastatic ACC''''' ==== | ==== '''''Radiation therapy in non-metastatic ACC''''' ==== | ||
* According to the National Cancer Data Base and | * According to the National Cancer Data Base and The Surveillance, Epidemiology, and End Results program, there is an evidence that [[radiotherapy]] might be effective.<ref name="pmid17188138">{{cite journal| author=Paton BL, Novitsky YW, Zerey M, Harrell AG, Norton HJ, Asbun H et al.| title=Outcomes of adrenal cortical carcinoma in the United States. | journal=Surgery | year= 2006 | volume= 140 | issue= 6 | pages= 914-20; discussion 919-20 | pmid=17188138 | doi=10.1016/j.surg.2006.07.035 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17188138 }}</ref> | ||
* Local recurrence-free survival was 86% in the group that received radiation compared with11%in those that did not | * Local recurrence-free survival was 86% in the group that received [[Radiation therapy|radiation]] compared with11%in those that did not.<ref name="pmid16895957">{{cite journal| author=Fassnacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M et al.| title=Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 11 | pages= 4501-4 | pmid=16895957 | doi=10.1210/jc.2006-1007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16895957 }}</ref> | ||
* Radiotherapy also can be used for treating unresectable masses. | * [[Radiotherapy]] also can be used for treating unresectable [[Mass|masses]].<ref name="pmid20675074">{{cite journal| author=Sabolch A, Feng M, Griffith K, Hammer G, Doherty G, Ben-Josef E| title=Adjuvant and definitive radiotherapy for adrenocortical carcinoma. | journal=Int J Radiat Oncol Biol Phys | year= 2011 | volume= 80 | issue= 5 | pages= 1477-84 | pmid=20675074 | doi=10.1016/j.ijrobp.2010.04.030 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20675074 }}</ref> | ||
==== '''''Radiation therapy for palliation''''' ==== | ==== '''''Radiation therapy for palliation''''' ==== | ||
* Seventy seven percent of patients with metastatic ACCs to bone experienced adequate palliation of pain after radiotherapy with dosages totaling 10 to 60 | * Seventy-seven percent of patients with [[Metastasis|metastatic]] ACCs to [[bone]] experienced adequate [[Palliative care|palliation]] of pain after [[radiotherapy]] with dosages totaling 10 to 60 Gyger.<ref name="pmid1709336">{{cite journal| author=Markoe AM, Serber W, Micaily B, Brady LW| title=Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. | journal=Am J Clin Oncol | year= 1991 | volume= 14 | issue= 2 | pages= 170-4 | pmid=1709336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1709336 }}</ref> | ||
* Radiofrequency ablation (RFA) and transarterial chemoembolization are an alternative to surgery | * [[Radiofrequency ablation]] ([[RFA]]) and transarterial [[chemoembolization]] are an alternative to surgery when surgery is not desired or contraindicated. | ||
* High local tumor regression can be achieved | * High local [[tumor]] [[regression]] can be achieved can be achieved with minimal systemic [[side effects]].<ref name="pmid21326571">{{cite journal| author=Thacker PG, Friese JL, Loe M, Biegler P, Larson M, Andrews J| title=Embolization of nonliver visceral tumors. | journal=Semin Intervent Radiol | year= 2009 | volume= 26 | issue= 3 | pages= 262-9 | pmid=21326571 | doi=10.1055/s-0029-1225667 | pmc=3036499 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21326571 }}</ref> | ||
* Bleeding is one of the complications as adrenal tumors have a tendency to undergo hemorrhage. | * [[Bleeding]] is one of the complications as [[Adrenal tumor|adrenal tumors]] have a tendency to undergo [[hemorrhage]].<ref name="pmid20237856">{{cite journal| author=de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A et al.| title=Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization. | journal=Ann Surg Oncol | year= 2010 | volume= 17 | issue= 8 | pages= 2081-9 | pmid=20237856 | doi=10.1245/s10434-010-0979-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20237856 }}</ref> | ||
==References== | ==References== | ||
Revision as of 14:16, 25 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Radiation therapyand radiofrequency ablation may be used for palliation in patients who are not surgical candidates.
Radiation Therapy
Radiotherapy has shown improvement in both the adjuvant and palliative ACCs.
Radiation therapy in non-metastatic ACC
- According to the National Cancer Data Base and The Surveillance, Epidemiology, and End Results program, there is an evidence that radiotherapy might be effective.[1]
- Local recurrence-free survival was 86% in the group that received radiation compared with11%in those that did not.[2]
- Radiotherapy also can be used for treating unresectable masses.[3]
Radiation therapy for palliation
- Seventy-seven percent of patients with metastatic ACCs to bone experienced adequate palliation of pain after radiotherapy with dosages totaling 10 to 60 Gyger.[4]
- Radiofrequency ablation (RFA) and transarterial chemoembolization are an alternative to surgery when surgery is not desired or contraindicated.
- High local tumor regression can be achieved can be achieved with minimal systemic side effects.[5]
- Bleeding is one of the complications as adrenal tumors have a tendency to undergo hemorrhage.[6]
References
- ↑ Paton BL, Novitsky YW, Zerey M, Harrell AG, Norton HJ, Asbun H; et al. (2006). "Outcomes of adrenal cortical carcinoma in the United States". Surgery. 140 (6): 914–20, discussion 919-20. doi:10.1016/j.surg.2006.07.035. PMID 17188138.
- ↑ Fassnacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M; et al. (2006). "Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma". J Clin Endocrinol Metab. 91 (11): 4501–4. doi:10.1210/jc.2006-1007. PMID 16895957.
- ↑ Sabolch A, Feng M, Griffith K, Hammer G, Doherty G, Ben-Josef E (2011). "Adjuvant and definitive radiotherapy for adrenocortical carcinoma". Int J Radiat Oncol Biol Phys. 80 (5): 1477–84. doi:10.1016/j.ijrobp.2010.04.030. PMID 20675074.
- ↑ Markoe AM, Serber W, Micaily B, Brady LW (1991). "Radiation therapy for adjunctive treatment of adrenal cortical carcinoma". Am J Clin Oncol. 14 (2): 170–4. PMID 1709336.
- ↑ Thacker PG, Friese JL, Loe M, Biegler P, Larson M, Andrews J (2009). "Embolization of nonliver visceral tumors". Semin Intervent Radiol. 26 (3): 262–9. doi:10.1055/s-0029-1225667. PMC 3036499. PMID 21326571.
- ↑ de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A; et al. (2010). "Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization". Ann Surg Oncol. 17 (8): 2081–9. doi:10.1245/s10434-010-0979-2. PMID 20237856.