Adrenocortical carcinoma history and symptoms: Difference between revisions
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* Twenty-five percent present with mixed overproduction of both [[glucocorticoids]] and [[androgens]].<ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640 }}</ref> | * Twenty-five percent present with mixed overproduction of both [[glucocorticoids]] and [[androgens]].<ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640 }}</ref> | ||
* Ten percent present with [[virilization]] alone | * Ten percent present with [[virilization]] alone | ||
1- Symptoms of [[glucocorticoid]] excess include: | 1- Symptoms of [[glucocorticoid]] excess include:<ref>{{Cite journal | ||
| author = [[Bibek Bista]] & [[Nancy Beck]] | |||
| title = Cushing syndrome | |||
| journal = [[Indian journal of pediatrics]] | |||
| volume = 81 | |||
| issue = 2 | |||
| pages = 158–164 | |||
| year = 2014 | |||
| month = February | |||
| doi = 10.1007/s12098-013-1203-8 | |||
| pmid = 24062268 | |||
}}</ref> | |||
*[[Weight gain]] | *[[Weight gain]] | ||
*[[Acne]] | *[[Acne]] | ||
| Line 15: | Line 27: | ||
*[[Insomnia]] | *[[Insomnia]] | ||
2- Symptoms of [[androgen]] excess symptoms (especially among women) include: | 2- Symptoms of [[androgen]] excess symptoms (especially among women) include:<ref>{{Cite journal | ||
| author = [[Lourdes Ibanez]], [[Ken K. Ong]], [[Abel Lopez-Bermejo]], [[David B. Dunger]] & [[Francis de Zegher]] | |||
| title = Hyperinsulinaemic androgen excess in adolescent girls | |||
| journal = [[Nature reviews. Endocrinology]] | |||
| volume = 10 | |||
| issue = 8 | |||
| pages = 499–508 | |||
| year = 2014 | |||
| month = August | |||
| doi = 10.1038/nrendo.2014.58 | |||
| pmid = 24776733 | |||
}}</ref> | |||
*[[Hirsutism|Excess facial and body hair]] | *[[Hirsutism|Excess facial and body hair]] | ||
*[[Acne]] | *[[Acne]] | ||
| Line 21: | Line 45: | ||
*Coarsening of facial features | *Coarsening of facial features | ||
*[[Amenorrhea|Cessation of menstruation]] | *[[Amenorrhea|Cessation of menstruation]] | ||
3- Symptoms of [[mineralcorticoid]] excess include: | 3- Symptoms of [[mineralcorticoid]] excess include:<ref>{{Cite journal | ||
| author = [[Valeria Bisogni]], [[Gian Paolo Rossi]] & [[Lorenzo A. Calo]] | |||
| title = Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology | |||
| journal = [[Blood pressure]] | |||
| volume = 23 | |||
| issue = 3 | |||
| pages = 189–192 | |||
| year = 2014 | |||
| month = June | |||
| doi = 10.3109/08037051.2013.832967 | |||
| pmid = 24053336 | |||
}}</ref> | |||
*[[Headache]] | *[[Headache]] | ||
*[[Muscle weakness]] | *[[Muscle weakness]] | ||
*[[Confusion]] | *[[Confusion]] | ||
*[[Palpitations]] | *[[Palpitations]] | ||
4- Symptoms of [[estrogen]] excess (especially among men) include: | 4- Symptoms of [[estrogen]] excess (especially among men) include:<ref>{{Cite journal | ||
| author = [[G. M. Zanetta]], [[M. J. Webb]], [[H. Li]] & [[G. L. Keeney]] | |||
| title = Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis | |||
| journal = [[Gynecologic oncology]] | |||
| volume = 79 | |||
| issue = 1 | |||
| pages = 18–22 | |||
| year = 2000 | |||
| month = October | |||
| doi = 10.1006/gyno.2000.5905 | |||
| pmid = 11006024 | |||
}}</ref> | |||
*[[Gynecomastia]] | *[[Gynecomastia]] | ||
*Decreased [[libido]] | *Decreased [[libido]] | ||
Revision as of 15:26, 25 September 2017
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Diagnosis |
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Adrenocortical carcinoma history and symptoms On the Web |
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Risk calculators and risk factors for Adrenocortical carcinoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]
Overview
Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess.
Common Symptoms
60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]
- Forty-five percent of ACCs show symptoms of Cushing's syndrome alone
- Twenty-five percent present with mixed overproduction of both glucocorticoids and androgens.[2]
- Ten percent present with virilization alone
1- Symptoms of glucocorticoid excess include:[3]
2- Symptoms of androgen excess symptoms (especially among women) include:[4]
- Excess facial and body hair
- Acne
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation
3- Symptoms of mineralcorticoid excess include:[5]
4- Symptoms of estrogen excess (especially among men) include:[6]
- Gynecomastia
- Decreased libido
- Impotence
5- symptoms of catecholamines excess has been reported in adrenocortical cancers:[7]
6- Other symptoms may include:[8]
- Abdominal lump
- Abdominal or back pain
- Abdominal fullness
Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%).[9]
References
- ↑ Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
- ↑ Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
- ↑ Bibek Bista & Nancy Beck (2014). "Cushing syndrome". Indian journal of pediatrics. 81 (2): 158–164. doi:10.1007/s12098-013-1203-8. PMID 24062268. Unknown parameter
|month=ignored (help) - ↑ Lourdes Ibanez, Ken K. Ong, Abel Lopez-Bermejo, David B. Dunger & Francis de Zegher (2014). "Hyperinsulinaemic androgen excess in adolescent girls". Nature reviews. Endocrinology. 10 (8): 499–508. doi:10.1038/nrendo.2014.58. PMID 24776733. Unknown parameter
|month=ignored (help) - ↑ Valeria Bisogni, Gian Paolo Rossi & Lorenzo A. Calo (2014). "Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology". Blood pressure. 23 (3): 189–192. doi:10.3109/08037051.2013.832967. PMID 24053336. Unknown parameter
|month=ignored (help) - ↑ G. M. Zanetta, M. J. Webb, H. Li & G. L. Keeney (2000). "Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis". Gynecologic oncology. 79 (1): 18–22. doi:10.1006/gyno.2000.5905. PMID 11006024. Unknown parameter
|month=ignored (help) - ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1
- ↑ Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.