Hypoparathyroidism CT: Difference between revisions
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==Overview== | ==Overview== | ||
Peripheral quantitative computed tomography (pQCT) and microcomputed tomography (microCT) may be helpful in the diagnosis of hypopparathyroidism. Findings on pQCT scan suggestive of hypoparathyroidism include increase in volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of both cortical and trabecular bones. Findings on | Peripheral quantitative computed tomography (pQCT) and microcomputed tomography (microCT) may be helpful in the diagnosis of hypopparathyroidism. Findings on pQCT scan suggestive of hypoparathyroidism include increase in volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of both cortical and trabecular bones. Findings on microcomputed tomography, and markedly elevated connectivity density (Conn D). | ||
==CT scan== | ==CT scan== | ||
===Peripheral quantitative computed tomography (pQCT)=== | ===Peripheral quantitative computed tomography (pQCT)=== | ||
*Peripheral quantitative computed tomography (pQCT) may be helpful in the diagnosis of hypopparathyroidism.<ref name="pmid14557436">{{cite journal |vauthors=Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K |title=Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue=10 |pages=4655–8 |year=2003 |pmid=14557436 |doi=10.1210/jc.2003-030470 |url=}}</ref> | *Peripheral quantitative computed tomography (pQCT) may be helpful in the diagnosis of hypopparathyroidism.<ref name="pmid14557436">{{cite journal |vauthors=Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K |title=Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue=10 |pages=4655–8 |year=2003 |pmid=14557436 |doi=10.1210/jc.2003-030470 |url=}}</ref><ref name="pmid26234545">{{cite journal |vauthors=Cusano NE, Nishiyama KK, Zhang C, Rubin MR, Boutroy S, McMahon DJ, Guo XE, Bilezikian JP |title=Noninvasive Assessment of Skeletal Microstructure and Estimated Bone Strength in Hypoparathyroidism |journal=J. Bone Miner. Res. |volume=31 |issue=2 |pages=308–16 |year=2016 |pmid=26234545 |pmc=4832602 |doi=10.1002/jbmr.2609 |url=}}</ref> | ||
*Findings on pQCT scan suggestive of hypoparathyroidism include: | *Findings on pQCT scan suggestive of hypoparathyroidism include: | ||
**Increase in volumetric bone mineral density (vBMD) of both cortical and trabecular bones. | **Increase in volumetric bone mineral density (vBMD) of both cortical and trabecular bones. | ||
Revision as of 17:51, 25 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
Peripheral quantitative computed tomography (pQCT) and microcomputed tomography (microCT) may be helpful in the diagnosis of hypopparathyroidism. Findings on pQCT scan suggestive of hypoparathyroidism include increase in volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of both cortical and trabecular bones. Findings on microcomputed tomography, and markedly elevated connectivity density (Conn D).
CT scan
Peripheral quantitative computed tomography (pQCT)
- Peripheral quantitative computed tomography (pQCT) may be helpful in the diagnosis of hypopparathyroidism.[1][2]
- Findings on pQCT scan suggestive of hypoparathyroidism include:
- Increase in volumetric bone mineral density (vBMD) of both cortical and trabecular bones.
- Increase in bone mineral density (BMD) of both cortical and trabecular bones.
Microcomputed tomography (microCT)
- Microcomputed tomography (microCT) may be helpful in the diagnosis of hypopparathyroidism.[3]
- Findings on microCT scan suggestive of hypoparathyroidism include:
- Greater cancellous bone volume (BV/TV)
- Markedly increased trabecular number (Tb.N)
- Markedly increased Trabecular thickness (Tb.Th)
- Lower trabecular separation (Tb.Sp)
- Markedly elevated connectivity density (Conn D)
- Note(1): A parameter that estimates the number of trabecular connections per millimeter cube is called connectivity density.
References
- ↑ Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K (2003). "Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects". J. Clin. Endocrinol. Metab. 88 (10): 4655–8. doi:10.1210/jc.2003-030470. PMID 14557436.
- ↑ Cusano NE, Nishiyama KK, Zhang C, Rubin MR, Boutroy S, McMahon DJ, Guo XE, Bilezikian JP (2016). "Noninvasive Assessment of Skeletal Microstructure and Estimated Bone Strength in Hypoparathyroidism". J. Bone Miner. Res. 31 (2): 308–16. doi:10.1002/jbmr.2609. PMC 4832602. PMID 26234545.
- ↑ Rubin MR, Dempster DW, Kohler T, Stauber M, Zhou H, Shane E, Nickolas T, Stein E, Sliney J, Silverberg SJ, Bilezikian JP, Müller R (2010). "Three dimensional cancellous bone structure in hypoparathyroidism". Bone. 46 (1): 190–5. doi:10.1016/j.bone.2009.09.020. PMC 2818211. PMID 19782782.