Sandbox:Amd: Difference between revisions

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!Other history/
!Other history/
findings
findings
!Hyponatremia
!Hypo
natremia
!Cortisol levels
!Cortisol levels
!Gold Standard
!Gold Standard
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|✔
|✔
|✔
|✔
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*Autoimmune/idiopathic
*Autoimmune/idiopathic
*Infections- Tuberculosis<ref name="pmid18591375">{{cite journal |vauthors=Patnaik MM, Deshpande AK |title=Diagnosis--Addison's disease secondary to tuberculosis of the adrenal glands |journal=Clin Med Res |volume=6 |issue=1 |pages=29 |year=2008 |pmid=18591375 |pmc=2442022 |doi=10.3121/cmr.2007.754a |url=}}</ref>, histoplasmosis
*Infections- Tuberculosis, histoplasmosis
|✔
|✔
|↓
|↓
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* [[Hypopituitarism]]- Tumors, infections. hemorrhage/trauma
* [[Hypopituitarism]]- Tumors, infections. hemorrhage/trauma
* Drugs- Chronic [[steroid]] therapy and its withdrawal, Opiates<ref name="pmid4823919">{{cite journal |vauthors=George JM, Reier CE, Lanese RR, Rower M |title=Morphine anesthesia blocks cortisol and growth hormone response to surgical stress in humans |journal=J. Clin. Endocrinol. Metab. |volume=38 |issue=5 |pages=736–41 |year=1974 |pmid=4823919 |doi=10.1210/jcem-38-5-736 |url=}}</ref><ref name="pmid17371484">{{cite journal |vauthors=Müssig K, Knaus-Dittmann D, Schmidt H, Mörike K, Häring HU |title=Secondary adrenal failure and secondary amenorrhoea following hydromorphone treatment |journal=Clin. Endocrinol. (Oxf) |volume=66 |issue=4 |pages=604–5 |year=2007 |pmid=17371484 |doi=10.1111/j.1365-2265.2007.02779.x |url=}}</ref>
* Drugs- Chronic [[steroid]] therapy and its withdrawal, Opiates
* [[Genetics|Genetic]]- Combined pituitary hormone deficiency (CPHD), POMC (Proopiomelanocortin) gene deficiency<ref name="pmid24354022">{{cite journal |vauthors=Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, Challis BG, Millington GWM |title= |journal= |volume= |issue= |pages= |year= |pmid=24354022 |doi= |url=}}</ref>
* [[Genetics|Genetic]]- Combined pituitary hormone deficiency (CPHD), POMC (Proopiomelanocortin) gene deficiency  
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|Normal
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<references />

Revision as of 19:54, 25 September 2017


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Adrenal Insufficiency

Disease Clinical history/findings Causes Investigations/

Laboratory findings

Medical management Surgical management
Hypotension Skin

pigmentation/

findings

Hypoglycemia Anorexia Abdominal pain Muscle weakness Other history/

findings

Hypo

natremia

Cortisol levels Gold Standard
Differentiating Primary from Secondary adrenal insufficiency
Primary adrenal

insufficiency

✔ ✔ ✔ ✔ ✔ ✔
  • Autoimmune/idiopathic
  • Infections- Tuberculosis, histoplasmosis
 ✔ ↓ Cosyntropin/

ACTH stimulation test

Secondary adrenal

insufficiency

✔ -
  • Hypopituitarism- Tumors, infections. hemorrhage/trauma
  • Drugs- Chronic steroid therapy and its withdrawal, Opiates
  • Genetic- Combined pituitary hormone deficiency (CPHD), POMC (Proopiomelanocortin) gene deficiency
 - Normal
Differentiating Adrenal Insufficiency from other diseases
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