De Quervain's thyroiditis from other diseases: Difference between revisions
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*[[Riedel's thyroiditis]] usually presents with hard and fixed thyroid mass | *[[Riedel's thyroiditis]] usually presents with hard and fixed thyroid mass | ||
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| align="center" style="background:#DCDCDC;" |[[Infectious thyroiditis]] | | align="center" style="background:#DCDCDC;" |[[Infectious thyroiditis]] |
Revision as of 21:22, 27 September 2017
De Quervain's thyroiditis Microchapters |
Differentiating De Quervain's thyroiditis from other Diseases |
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Diagnosis |
Treatment |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
De Quervain's thyroiditis must be differentiated from other causes of thyroiditis, such as Hashimoto's thyroiditis, Riedel's thyroiditis, and suppurative thyroiditis.
Differentiating De Quervain's thyroiditis from other diseases
- De Quervain's thyroiditis must be differentiated from other causes of thyroiditis, such as Hashimoto's thyroiditis, Riedel's thyroiditis, and suppurative thyroiditis.[1]
Conditions | Causes | Age at onset | Pathological findings | Diagnostic approach |
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Painful subacute (De Quervain's) thyroiditis |
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Hashimoto's thyroiditis |
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Silent thyroiditis |
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Postpartum thyroiditis |
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Riedel's thyroiditis |
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Suppurative thyroiditis |
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- De Quervain's thyroiditis must be differentiated from other causes of hypothyroidism on the basis of history and symptoms and laboratory findings:[2][3][1][4][5][6]
Disease | History and symptoms | Laboratory findings | Additional findings | ||||||||
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Fever | Pain | TSH | Free T4 | T3 | T3RU† | Thyroglobin | TRH | TPOAb^ | |||
Transient hypothyroidism | Subacute (de Quervain's) thyroiditis | +/- | +/- | ↑/↓ | ↓/↑ | Normal | ↓ | ↑ | Normal | Low/absent |
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Postpartum thyroiditis | +/- | +/- | ↑/↓ | ↓/↑ | Normal | ↓ | ↑ | Normal/↑ | Present (high titer) |
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Silent thyroiditis | - | - | ↑/↓ | ↓/↑ | Normal | ↓ | ↑ | Normal | Present (high titer) |
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Primary hypothyroidism | Autoimmune (Hashimoto's thyroiditis) | - | - | ↑* | ↓ | Normal/↓ | Normal/↓ | Normal/↑ | Normal | Present (high titer) |
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Riedel's thyroiditis | - | - | Normal/↑ | Normal/↓ | Normal/↓ | Normal/↓ | Normal | Normal | Usually present |
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Infectious thyroiditis | + | + | Normal | Normal | Normal | Normal | Normal | Normal | Absent |
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Others | Drug-induced | - | - | ↑/↓ | ↓/↑ | Normal | ↓ | Normal/↑ | Normal | Absent** |
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Radiation-induced | |||||||||||
Trauma induced | |||||||||||
Radioiodine induced | |||||||||||
Thyroidectomy | |||||||||||
Subclinical hypothyroidism | - | - | ↑ | Normal | Normal | Normal | Normal | Normal | Normal/↑ |
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(†)T3RU; Triiodothyronine Resin uptake. (^)TPOAb; Thyroid peroxidase antibodies. (*)TSH may be decreased transiently in the thyrotoxicosis. (**)TPOAb may be present in drug-induced hypo/hyperthyroidism such as Interferon-alpha, interleukin-2, and lithium.
References
- ↑ 1.0 1.1 "Thyroiditis — NEJM".
- ↑ Bindra A, Braunstein GD (2006). "Thyroiditis". Am Fam Physician. 73 (10): 1769–76. PMID 16734054.
- ↑ McDermott MT (2009). "In the clinic. Hypothyroidism". Ann. Intern. Med. 151 (11): ITC61. doi:10.7326/0003-4819-151-11-200912010-01006. PMID 19949140.
- ↑ Aoki Y, Belin RM, Clickner R, Jeffries R, Phillips L, Mahaffey KR (2007). "Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002)". Thyroid. 17 (12): 1211–23. doi:10.1089/thy.2006.0235. PMID 18177256.
- ↑ Lania A, Persani L, Beck-Peccoz P (2008). "Central hypothyroidism". Pituitary. 11 (2): 181–6. doi:10.1007/s11102-008-0122-6. PMID 18415684.
- ↑ De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A, Stockigt J. "Clinical Strategies in the Testing of Thyroid Function". PMID 25905413.