Rabies natural history, complications and prognosis: Difference between revisions
m Changes made per Mahshid's request |
Iqra Qamar (talk | contribs) |
||
| Line 6: | Line 6: | ||
==Natural History== | ==Natural History== | ||
* Rabies runs its course very rapidly throughout the body. Once symptoms begin to appear, the disease is almost always [[fatal]]. | * Rabies runs its course very rapidly throughout the body. Once symptoms begin to appear, the disease is almost always [[fatal]].<ref name="pmid23602163">{{cite journal |vauthors=Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J |title=Human rabies: neuropathogenesis, diagnosis, and management |journal=Lancet Neurol |volume=12 |issue=5 |pages=498–513 |year=2013 |pmid=23602163 |doi=10.1016/S1474-4422(13)70038-3 |url=}}</ref><ref name="pmid5082226">{{cite journal |vauthors=Hattwick MA |title=Reactions to rabies |journal=N. Engl. J. Med. |volume=287 |issue=23 |pages=1204 |year=1972 |pmid=5082226 |doi= |url=}}</ref> | ||
* The period between infection and the first [[flu]]-like symptoms is normally two to twelve weeks, but can be as long as two years. | * The period between infection and the first [[flu]]-like symptoms is normally two to twelve weeks, but can be as long as two years. | ||
* The acute period of disease typically ends after 2 to 10 days. | * The acute period of disease typically ends after 2 to 10 days. | ||
Revision as of 11:44, 28 September 2017
|
Rabies Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Rabies natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Rabies natural history, complications and prognosis |
|
Rabies natural history, complications and prognosis in the news |
|
Blogs on Rabies natural history, complications and prognosis |
|
Risk calculators and risk factors for Rabies natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Natural History
- Rabies runs its course very rapidly throughout the body. Once symptoms begin to appear, the disease is almost always fatal.[1][2]
- The period between infection and the first flu-like symptoms is normally two to twelve weeks, but can be as long as two years.
- The acute period of disease typically ends after 2 to 10 days.
- To date only six documented cases of human survival from clinical rabies have been reported and each included a history of either pre- or postexposure prophylaxis.
- The few humans who are known to have survived the disease were all left with severe brain damage, with the recent exception of Jeanna Giese.
Complications
Prognosis
Treatment after exposure (receiving the vaccines), known as post-exposure prophylaxis (PEP), is highly successful in preventing the disease if administered promptly, in general within ten days of infection. Begun with little or no delay, PEP is 100% effective against rabies.[3] In the case in which there has been a significant delay in administering PEP, the treatment should be administered regardless of that delay, as it may still be effective.
In unvaccinated humans, rabies is usually fatal after neurological symptoms have developed, but prompt post-exposure vaccination may prevent the virus from progressing. Rabies kills around 55,000 people a year, mostly in Asia and Africa.[4]
Survival data using the Milwaukee protocol are available from the rabies registry.[5] As of 2011, seven people have been saved by this induced coma treatment.
References
- ↑ Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J (2013). "Human rabies: neuropathogenesis, diagnosis, and management". Lancet Neurol. 12 (5): 498–513. doi:10.1016/S1474-4422(13)70038-3. PMID 23602163.
- ↑ Hattwick MA (1972). "Reactions to rabies". N. Engl. J. Med. 287 (23): 1204. PMID 5082226.
- ↑ Jordan Lite (2008-10-08). "Medical Mystery: Only One Person Has Survived Rabies without Vaccine--But How?". Scientific American. Retrieved 2010-01-30.
- ↑ "Rabies". World Health Organization (WHO). September 2011. Retrieved 31 December 2011.
- ↑ "Rabies Registry". Medical College of Wisconsin. Retrieved 29 December 2009.