Autoimmune polyendocrine syndrome classification: Difference between revisions
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==Overview== | ==Overview== | ||
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 commonly presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia | On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 commonly presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia. | ||
==Classification== | ==Classification== | ||
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3 | On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. | ||
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Autoimmune polyendocrine syndrome (APS) type 3 can be further classified into APS type 3A, APS type 3B and APS type 3C | Autoimmune polyendocrine syndrome (APS) type 3 can be further classified into APS type 3A, APS type 3B and APS type 3C. | ||
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===Other diseases=== | ===Other diseases=== | ||
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* Chromosomal abnormalities ([[Down's syndrome]]) increase the risk of endocrine autoimmunity | * Chromosomal abnormalities ([[Down's syndrome]]) increase the risk of endocrine autoimmunity | ||
* POEMS syndrome - the ''E'' is for endocrinopathy; the cause is a [[paraprotein]] excreted by a plasmacytoma or [[multiple myeloma]]; other features are [[polyneuropathy]], organomegaly ([[hepatomegaly]] and [[splenomegaly]]), M-protein (paraprotein) and skin changes. | * POEMS syndrome - the ''E'' is for endocrinopathy; the cause is a [[paraprotein]] excreted by a plasmacytoma or [[multiple myeloma]]; other features are [[polyneuropathy]], organomegaly ([[hepatomegaly]] and [[splenomegaly]]), M-protein (paraprotein) and skin changes. | ||
==Classification== | ==Classification== | ||
* | * | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 19:46, 3 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 commonly presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia.
Classification
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3.
| Autoimmune polyendocrine syndrome (APS) | |||||||||||||||||||||||||||||||||||
| Autoimmune polyendocrine syndrome type 1 | Autoimmune polyendocrine syndrome type 2 | Autoimmune polyendocrine syndrome type 3 | |||||||||||||||||||||||||||||||||
| •Mucocutaneous candidiasis •Hypoparathyroidism •Addison's disease | •Addison's disease •Autoimmune thyroiditis •Diabetes mellitus type 1 | •Autoimmune thyroiditis •Diabetes mellitus type 1 •Pernicious anemia | |||||||||||||||||||||||||||||||||
Autoimmune polyendocrine syndrome (APS) type 3 can be further classified into APS type 3A, APS type 3B and APS type 3C.
| Autoimmune polyendocrine syndrome type 3 | |||||||||||||||||||||||||||||||||||
| Autoimmune polyendocrine syndrome type 3A | Autoimmune polyendocrine syndrome type 3B | Autoimmune polyendocrine syndrome type 3C | |||||||||||||||||||||||||||||||||
| •Autoimmune thyroiditis •Immune mediated diabetes mellitus | •Autoimmune thyroiditis •Pernicious anemia | •Autoimmune thyroiditis •Vitiligo/Alopecia | |||||||||||||||||||||||||||||||||
Other diseases
Other diseases featuring polyendocrine autoimmunity:
- Chromosomal abnormalities (Down's syndrome) increase the risk of endocrine autoimmunity
- POEMS syndrome - the E is for endocrinopathy; the cause is a paraprotein excreted by a plasmacytoma or multiple myeloma; other features are polyneuropathy, organomegaly (hepatomegaly and splenomegaly), M-protein (paraprotein) and skin changes.