Autoimmune polyendocrine syndrome overview: Difference between revisions
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==Classification== | ==Classification== | ||
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous [[candidiasis]], [[hypoparathyroidism]] and [[Addison's disease]]. APS type 2 commonly presents with [[Addison's disease]], [[autoimmune thyroiditis]] and [[diabetes mellitus type 1]]. APS type 3 commonly presents with [[autoimmune thyroiditis]], [[diabetes mellitus type 1]] and [[pernicious anemia]]. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 18:14, 5 October 2017
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Autoimmune polyendocrine syndrome Microchapters |
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Differentiating Autoimmune polyendocrine syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Autoimmune polyendocrine syndrome overview On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Historical Perspective
In 19th century physicians first focussed their attention on constellation of symptoms associated with autoimmune polyendocrine syndrome. In 1855, Thomas Addison identified patients with Addison's disease who also appeared to have coexisting pernicious anemia. In 1956, Roitt and Doniach found that patients with Hashimoto's thyroiditis had circulating autoantibodies reacting with thyroid gland. In 1980, Neufeld and Blizzard first developed the classification for polyglandular failure and in 1982 categorised autoimmune polyendocrine syndrome into type 1 and type 2.
Classification
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 commonly presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia.